SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ugz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		 5ugz PUTATIVE
THIOESTERASE
(Escherichia
coli) 		3 / 3 ASP A 158
LEU A   9
LEU A  79
 None
 0.66A 1ikeA-5ugzA:
undetectable		 1ikeA-5ugzA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_A_BEZA349_0
(D-AMINO ACID OXIDASE)		 5ugz PUTATIVE
THIOESTERASE
(Escherichia
coli) 		4 / 5 TYR A  67
TYR A   7
ILE A  74
GLY A  70
 None
 1.30A 1kifA-5ugzA:
2.4		 1kifA-5ugzA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_B_BEZB349_0
(D-AMINO ACID OXIDASE)		 5ugz PUTATIVE
THIOESTERASE
(Escherichia
coli) 		4 / 5 TYR A  67
TYR A   7
ILE A  74
GLY A  70
 None
 1.29A 1kifB-5ugzA:
2.5		 1kifB-5ugzA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_C_BEZC349_0
(D-AMINO ACID OXIDASE)		 5ugz PUTATIVE
THIOESTERASE
(Escherichia
coli) 		4 / 5 TYR A  67
TYR A   7
ILE A  74
GLY A  70
 None
 1.30A 1kifC-5ugzA:
undetectable		 1kifC-5ugzA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_D_BEZD349_0
(D-AMINO ACID OXIDASE)		 5ugz PUTATIVE
THIOESTERASE
(Escherichia
coli) 		4 / 5 TYR A  67
TYR A   7
ILE A  74
GLY A  70
 None
 1.29A 1kifD-5ugzA:
undetectable		 1kifD-5ugzA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_E_BEZE349_0
(D-AMINO ACID OXIDASE)		 5ugz PUTATIVE
THIOESTERASE
(Escherichia
coli) 		4 / 5 TYR A  67
TYR A   7
ILE A  74
GLY A  70
 None
 1.30A 1kifE-5ugzA:
undetectable		 1kifE-5ugzA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_F_BEZF349_0
(D-AMINO ACID OXIDASE)		 5ugz PUTATIVE
THIOESTERASE
(Escherichia
coli) 		4 / 5 TYR A  67
TYR A   7
ILE A  74
GLY A  70
 None
 1.29A 1kifF-5ugzA:
undetectable		 1kifF-5ugzA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_G_BEZG349_0
(D-AMINO ACID OXIDASE)		 5ugz PUTATIVE
THIOESTERASE
(Escherichia
coli) 		4 / 5 TYR A  67
TYR A   7
ILE A  74
GLY A  70
 None
 1.30A 1kifG-5ugzA:
2.5		 1kifG-5ugzA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_H_BEZH349_0
(D-AMINO ACID OXIDASE)		 5ugz PUTATIVE
THIOESTERASE
(Escherichia
coli) 		4 / 5 TYR A  67
TYR A   7
ILE A  74
GLY A  70
 None
 1.29A 1kifH-5ugzA:
2.5		 1kifH-5ugzA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		 5ugz PUTATIVE
THIOESTERASE
(Escherichia
coli) 		3 / 3 ASP A 158
LEU A   9
LEU A  79
 None
 0.65A 1np1B-5ugzA:
undetectable		 1np1B-5ugzA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE9_A_BEZA352_0
(D-AMINO ACID OXIDASE)		 5ugz PUTATIVE
THIOESTERASE
(Escherichia
coli) 		4 / 5 TYR A  67
TYR A   7
ILE A  74
GLY A  70
 None
 1.33A 1ve9A-5ugzA:
undetectable		 1ve9A-5ugzA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_G_BEZG2352_0
(D-AMINO-ACID OXIDASE)		 5ugz PUTATIVE
THIOESTERASE
(Escherichia
coli) 		4 / 5 TYR A  67
TYR A   7
ILE A  74
GLY A  70
 None
 1.23A 2du8G-5ugzA:
undetectable		 2du8G-5ugzA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM7_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5ugz PUTATIVE
THIOESTERASE
(Escherichia
coli) 		5 / 10 TYR A 165
ASP A 111
PHE A 200
GLY A  81
ILE A  82
 None
 1.43A 2zm7A-5ugzA:
undetectable		 2zm7A-5ugzA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMA_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5ugz PUTATIVE
THIOESTERASE
(Escherichia
coli) 		5 / 11 TYR A 165
ASP A 111
PHE A 200
GLY A  81
ILE A  82
 None
 1.44A 2zmaA-5ugzA:
undetectable		 2zmaA-5ugzA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGR_A_T27A556_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H
P51 RT)		 5ugz PUTATIVE
THIOESTERASE
(Escherichia
coli) 		5 / 11 LEU A 134
VAL A 117
TYR A 162
LEU A 188
GLU A 130
 None
 1.44A 3bgrA-5ugzA:
undetectable
3bgrB-5ugzA:
undetectable		 3bgrA-5ugzA:
18.09
3bgrB-5ugzA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_C_ZMRC601_2
(NEURAMINIDASE)		 5ugz PUTATIVE
THIOESTERASE
(Escherichia
coli) 		3 / 3 ARG A  40
ARG A  43
ILE A 154
 None
BME  A 301 ( 4.6A)
None
 0.90A 4b7qC-5ugzA:
undetectable		 4b7qC-5ugzA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_A_ACTA703_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 5ugz PUTATIVE
THIOESTERASE
(Escherichia
coli) 		4 / 6 ALA A 113
PRO A 110
PHE A  85
GLU A  86
 None
 1.43A 5odqA-5ugzA:
4.9		 5odqA-5ugzA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V02_R_657R201_0
(CALMODULIN-1
SMALL CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
PROTEIN 2)		 5ugz PUTATIVE
THIOESTERASE
(Escherichia
coli) 		5 / 10 LEU A  59
LEU A   9
MET A  83
GLU A  86
ILE A  74
 None
 0.90A 5v02B-5ugzA:
undetectable
5v02R-5ugzA:
undetectable		 5v02B-5ugzA:
16.48
5v02R-5ugzA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 5ugz PUTATIVE
THIOESTERASE
(Escherichia
coli) 		4 / 5 MET A  18
TYR A  11
GLY A  80
GLY A  81
 None
 1.10A 5x7pA-5ugzA:
undetectable		 5x7pA-5ugzA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ESM_A_PZEA307_1
(MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9)		 5ugz PUTATIVE
THIOESTERASE
(Escherichia
coli) 		3 / 3 TYR A  11
HIS A 215
PHE A 216
 None
 1.02A 6esmA-5ugzA:
2.2		 6esmA-5ugzA:
15.74