SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5uh0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_2
(ALPHA-AMYLASE)		 5uh0 MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE F
(Yersinia
pestis) 		3 / 3 TRP A 230
TYR A 126
LEU A 257
 None
 1.08A 1kxhA-5uh0A:
undetectable		 1kxhA-5uh0A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5uh0 MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE F
(Yersinia
pestis) 		5 / 12 LEU A 209
LEU A 216
GLY A 201
ASP A 202
ALA A 154
 None
 0.97A 2bm9E-5uh0A:
undetectable		 2bm9E-5uh0A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5uh0 MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE F
(Yersinia
pestis) 		5 / 12 LEU A 209
LEU A 216
GLY A 201
ASP A 202
ALA A 154
 None
 1.03A 2br4D-5uh0A:
undetectable		 2br4D-5uh0A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELU_A_SAMA4633_0
(METHYLTRANSFERASE)		 5uh0 MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE F
(Yersinia
pestis) 		5 / 12 GLY A 108
GLY A 184
VAL A 133
ASP A 202
ILE A 206
 None
 0.92A 3eluA-5uh0A:
undetectable		 3eluA-5uh0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EMB_A_SAMA4633_0
(METHYLTRANSFERASE)		 5uh0 MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE F
(Yersinia
pestis) 		5 / 12 GLY A 108
GLY A 184
VAL A 133
ASP A 202
ILE A 206
 None
 0.97A 3embA-5uh0A:
undetectable		 3embA-5uh0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCZ_A_SAMA4633_0
(POLYPROTEIN)		 5uh0 MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE F
(Yersinia
pestis) 		5 / 12 GLY A 108
GLY A 184
VAL A 133
ASP A 202
ILE A 206
 None
 0.97A 3gczA-5uh0A:
undetectable		 3gczA-5uh0A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A83_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 5uh0 MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE F
(Yersinia
pestis) 		5 / 12 PHE A 232
LEU A  45
ILE A  39
ALA A 242
SER A 239
 None
 1.32A 4a83A-5uh0A:
undetectable		 4a83A-5uh0A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_A_ACTA502_0
(RNA-DEPENDENT RNA
POLYMERASE)		 5uh0 MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE F
(Yersinia
pestis) 		4 / 5 LYS A  72
LEU A  70
GLU A  69
LEU A 260
 None
 1.09A 4k4yA-5uh0A:
undetectable		 4k4yA-5uh0A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_E_ACTE503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 5uh0 MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE F
(Yersinia
pestis) 		4 / 4 LYS A  72
LEU A  70
GLU A  69
LEU A 260
 None
 1.10A 4k4yE-5uh0A:
undetectable		 4k4yE-5uh0A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_I_ACTI503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 5uh0 MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE F
(Yersinia
pestis) 		4 / 5 LYS A  72
LEU A  70
GLU A  69
LEU A 260
 None
 1.10A 4k4yI-5uh0A:
undetectable		 4k4yI-5uh0A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5uh0 MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE F
(Yersinia
pestis) 		5 / 12 VAL A 228
ALA A 107
ASP A  67
MET A 244
PHE A 247
 None
 1.41A 4kyaB-5uh0A:
undetectable		 4kyaB-5uh0A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_D_FOLD703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5uh0 MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE F
(Yersinia
pestis) 		5 / 12 VAL A 228
ALA A 107
ASP A  67
MET A 244
PHE A 247
 None
 1.44A 4kyaD-5uh0A:
undetectable		 4kyaD-5uh0A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_F_FOLF703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5uh0 MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE F
(Yersinia
pestis) 		5 / 12 VAL A 228
ALA A 107
ASP A  67
MET A 244
PHE A 247
 None
 1.43A 4kyaF-5uh0A:
undetectable		 4kyaF-5uh0A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_H_FOLH703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5uh0 MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE F
(Yersinia
pestis) 		5 / 12 VAL A 228
ALA A 107
ASP A  67
MET A 244
PHE A 247
 None
 1.45A 4kyaH-5uh0A:
undetectable		 4kyaH-5uh0A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHI_A_SAMA4001_0
(NS5
METHYLTRANSFERASE
DENGUE VIRUS)		 5uh0 MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE F
(Yersinia
pestis) 		5 / 12 GLY A 108
GLY A 184
VAL A 133
ASP A 202
ILE A 206
 None
 1.02A 5ehiA-5uh0A:
undetectable		 5ehiA-5uh0A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 5uh0 MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE F
(Yersinia
pestis) 		4 / 5 PRO A  86
LEU A 209
TYR A 264
PHE A  66
 None
 1.30A 5igjA-5uh0A:
undetectable		 5igjA-5uh0A:
22.74