SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5uhd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXH_B_PACB1001_0
(PENICILLIN ACYLASE)		 5uhd RNA POLYMERASE SIGMA
FACTOR SIGA
(Mycobacterium
tuberculosis) 		4 / 7 PHE F 335
PHE F 343
ALA F 250
ILE F 253
 None
 1.01A 1fxhA-5uhdF:
undetectable
1fxhB-5uhdF:
2.6		 1fxhA-5uhdF:
17.56
1fxhB-5uhdF:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_A_STRA1001_1
(MINERALOCORTICOID
RECEPTOR)		 5uhd RNA POLYMERASE SIGMA
FACTOR SIGA
(Mycobacterium
tuberculosis) 		5 / 12 LEU F 257
LEU F 249
ALA F 291
LEU F 296
THR F 260
 None
 1.29A 1ya3A-5uhdF:
undetectable		 1ya3A-5uhdF:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA5_B_STRB302_1
(MINERALOCORTICOID
RECEPTOR)		 5uhd RNA POLYMERASE SIGMA
FACTOR SIGA
(Mycobacterium
tuberculosis) 		5 / 12 LEU F 257
LEU F 249
ALA F 291
LEU F 296
THR F 260
 None
 1.28A 2aa5B-5uhdF:
undetectable		 2aa5B-5uhdF:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P16_A_GG2A298_2
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 5uhd RNA POLYMERASE SIGMA
FACTOR SIGA
(Mycobacterium
tuberculosis) 		3 / 3 ARG F 502
GLU F 501
GLN F 505
 None
 0.82A 2p16A-5uhdF:
undetectable		 2p16A-5uhdF:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1375_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5uhd RNA POLYMERASE SIGMA
FACTOR SIGA
(Mycobacterium
tuberculosis) 		3 / 3 LEU F 232
TYR F 231
GLN F 234
 None
 0.64A 2wekA-5uhdF:
undetectable		 2wekA-5uhdF:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 5uhd RNA POLYMERASE SIGMA
FACTOR SIGA
(Mycobacterium
tuberculosis) 		5 / 11 GLY F 288
ALA F 291
ILE F 284
ALA F 259
ASP F 289
 None
 1.12A 3nmuB-5uhdF:
3.0
3nmuJ-5uhdF:
undetectable		 3nmuB-5uhdF:
22.24
3nmuJ-5uhdF:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_I_SAMI228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 5uhd RNA POLYMERASE SIGMA
FACTOR SIGA
(Mycobacterium
tuberculosis) 		5 / 12 GLY F 288
ALA F 291
ILE F 284
ALA F 259
ASP F 289
 None
 1.14A 3nvkI-5uhdF:
undetectable		 3nvkI-5uhdF:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_B_017B202_1
(PROTEASE)		 5uhd DNA-DIRECTED RNA
POLYMERASE SUBUNIT
ALPHA
(Mycobacterium
tuberculosis) 		4 / 7 PRO A  67
LYS A 131
GLY A 101
PRO A 102
 None
 1.27A 3ucbB-5uhdA:
undetectable		 3ucbB-5uhdA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 5uhd RNA POLYMERASE SIGMA
FACTOR SIGA
(Mycobacterium
tuberculosis) 		5 / 12 GLU F 398
LEU F 386
ARG F 392
GLY F 380
LEU F 379
 None
 1.29A 4j26A-5uhdF:
undetectable		 4j26A-5uhdF:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 5uhd DNA-DIRECTED RNA
POLYMERASE SUBUNIT
ALPHA
(Mycobacterium
tuberculosis) 		3 / 3 SER A  86
ALA A  50
VAL A  51
 None
 0.60A 4o2bA-5uhdA:
undetectable		 4o2bA-5uhdA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		 5uhd DNA-DIRECTED RNA
POLYMERASE SUBUNIT
ALPHA
(Mycobacterium
tuberculosis) 		4 / 6 VAL A 136
LEU A  83
ILE A 110
ALA A 126
 None
 0.71A 4zf8A-5uhdA:
undetectable		 4zf8A-5uhdA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DX3_A_ESTA601_1
(ESTROGEN RECEPTOR)		 5uhd RNA POLYMERASE SIGMA
FACTOR SIGA
(Mycobacterium
tuberculosis) 		5 / 10 GLU F 398
LEU F 386
ARG F 392
GLY F 380
LEU F 379
 None
 1.30A 5dx3A-5uhdF:
undetectable		 5dx3A-5uhdF:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 5uhd RNA POLYMERASE SIGMA
FACTOR SIGA
(Mycobacterium
tuberculosis) 		5 / 10 GLU F 398
LEU F 386
ARG F 392
GLY F 380
LEU F 379
 None
 1.30A 5dxbA-5uhdF:
undetectable		 5dxbA-5uhdF:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWZ_B_BEZB301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5uhd RNA POLYMERASE SIGMA
FACTOR SIGA
(Mycobacterium
tuberculosis) 		3 / 3 MET F 281
GLN F 277
ARG F 278
 None
 1.10A 5ewzB-5uhdF:
4.8		 5ewzB-5uhdF:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_A_FUAA1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 5uhd DNA-DIRECTED RNA
POLYMERASE SUBUNIT
ALPHA
(Mycobacterium
tuberculosis) 		4 / 5 ILE A  76
ILE A 162
HIS A  61
VAL A  59
 None
 0.93A 5jmnA-5uhdA:
4.3		 5jmnA-5uhdA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WGQ_A_ESTA601_1
(ESTROGEN RECEPTOR)		 5uhd RNA POLYMERASE SIGMA
FACTOR SIGA
(Mycobacterium
tuberculosis) 		5 / 9 GLU F 398
LEU F 386
ARG F 392
GLY F 380
LEU F 379
 None
 1.33A 5wgqA-5uhdF:
undetectable		 5wgqA-5uhdF:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLP_A_GAWA1501_0
(SUBSTANCE-P
RECEPTOR,SUBSTANCE-P
RECEPTOR)		 5uhd DNA-DIRECTED RNA
POLYMERASE SUBUNIT
ALPHA
(Mycobacterium
tuberculosis) 		5 / 12 PRO A 163
ILE A 162
VAL A  73
THR A  74
ILE A  77
 None
 0.87A 6hlpA-5uhdA:
undetectable		 6hlpA-5uhdA:
20.49