SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5uhk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_D_NIOD223_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5uhk O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		4 / 5 PHE A 145
GLY A 140
THR A 217
PHE A 173
 None
 1.34A 1icuC-5uhkA:
undetectable
1icuD-5uhkA:
undetectable		 1icuC-5uhkA:
20.98
1icuD-5uhkA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_B_NIOB702_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5uhk O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		4 / 5 PHE A 145
GLY A 140
THR A 217
PHE A 173
 None
 1.33A 1icvA-5uhkA:
undetectable
1icvB-5uhkA:
undetectable		 1icvA-5uhkA:
20.98
1icvB-5uhkA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1868_0
(FPRA)		 5uhk O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		3 / 3 ALA A 192
HIS A 193
VAL A 196
 None
 0.32A 1lqtB-5uhkA:
undetectable		 1lqtB-5uhkA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1425_0
(FPRA)		 5uhk O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		3 / 3 ALA A 192
HIS A 193
VAL A 196
 None
 0.33A 1lquB-5uhkA:
undetectable		 1lquB-5uhkA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MCN_P_DHIP1_0
(IMMUNOGLOBULIN
LAMBDA DIMER MCG
(LIGHT CHAIN)
PEPTIDE
N-ACETYL-D-HIS-L-PRO
-NH2)		 5uhk O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		3 / 3 PHE A 214
TYR A 233
PRO A 216
 None
 0.99A 1mcnA-5uhkA:
undetectable
1mcnB-5uhkA:
undetectable
1mcnP-5uhkA:
undetectable		 1mcnA-5uhkA:
20.11
1mcnB-5uhkA:
20.11
1mcnP-5uhkA:
2.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_2
(DIPEPTIDYL PEPTIDASE
IV)		 5uhk O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		3 / 3 ARG A  71
SER A 112
TYR A 111
 None
 0.77A 1x70A-5uhkA:
undetectable		 1x70A-5uhkA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 5uhk O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		4 / 8 THR A  92
LEU A 311
VAL A 276
GLY A 309
 None
 0.85A 2a1oA-5uhkA:
undetectable		 2a1oA-5uhkA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_C_ADNC903_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 5uhk O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		5 / 12 ASN A 321
ALA A 320
TYR A 286
HIS A 282
PHE A 292
 None
 1.48A 2gl0A-5uhkA:
undetectable
2gl0C-5uhkA:
undetectable		 2gl0A-5uhkA:
18.35
2gl0C-5uhkA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W4X_A_STZA1591_1
(O-GLCNACASE BT_4395)		 5uhk O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		10 / 11 ASP A 174
CYH A 215
TYR A 219
THR A 250
VAL A 254
TRP A 278
ASN A 280
ASP A 285
TYR A 286
ASN A 313
 GOL  A 501 (-3.1A)
GOL  A 501 ( 4.0A)
GOL  A 501 (-3.3A)
GOL  A 501 (-4.4A)
None
GOL  A 501 (-3.6A)
GOL  A 501 (-3.4A)
GOL  A 502 (-2.9A)
None
GOL  A 502 (-3.4A)
 0.55A 2w4xA-5uhkA:
35.0		 2w4xA-5uhkA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X0Y_A_X0TA1625_1
(O-GLCNACASE NAGJ)		 5uhk O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		9 / 12 LYS A  98
ASP A 174
TYR A 219
THR A 250
VAL A 254
TRP A 278
ASN A 280
ASP A 285
ASN A 313
 GOL  A 502 (-4.0A)
GOL  A 501 (-3.1A)
GOL  A 501 (-3.3A)
GOL  A 501 (-4.4A)
None
GOL  A 501 (-3.6A)
GOL  A 501 (-3.4A)
GOL  A 502 (-2.9A)
GOL  A 502 (-3.4A)
 0.73A 2x0yA-5uhkA:
37.4		 2x0yA-5uhkA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X0Y_B_X0TB1625_1
(O-GLCNACASE NAGJ)		 5uhk O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		9 / 12 LYS A  98
ASP A 174
TYR A 219
THR A 250
TRP A 278
ASN A 280
ASP A 285
TYR A 286
ASN A 313
 GOL  A 502 (-4.0A)
GOL  A 501 (-3.1A)
GOL  A 501 (-3.3A)
GOL  A 501 (-4.4A)
GOL  A 501 (-3.6A)
GOL  A 501 (-3.4A)
GOL  A 502 (-2.9A)
None
GOL  A 502 (-3.4A)
 0.64A 2x0yB-5uhkA:
35.6		 2x0yB-5uhkA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_A_ACHA1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5uhk O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		4 / 6 TYR A 111
TYR A 135
TYR A  95
ILE A 123
 None
 1.38A 2xz5A-5uhkA:
undetectable
2xz5B-5uhkA:
undetectable		 2xz5A-5uhkA:
18.75
2xz5B-5uhkA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_D_VD3D2001_1
(VITAMIN D
HYDROXYLASE)		 5uhk O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		5 / 12 PRO A 209
ILE A 134
LEU A 171
ALA A  96
LEU A 248
 None
 1.13A 3a50D-5uhkA:
undetectable		 3a50D-5uhkA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQT_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5uhk O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		4 / 6 ARG A  84
TRP A  73
PHE A 318
GLU A 317
 None
 1.47A 3dqtA-5uhkA:
0.5
3dqtB-5uhkA:
undetectable		 3dqtA-5uhkA:
20.63
3dqtB-5uhkA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5uhk O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		4 / 5 ARG A  59
LEU A  94
ILE A 123
PHE A 133
 None
 1.32A 3ln1D-5uhkA:
undetectable		 3ln1D-5uhkA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5P_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE)		 5uhk O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		4 / 6 TRP A  73
PHE A 318
GLU A 317
ARG A  84
 None
 1.49A 3n5pA-5uhkA:
undetectable
3n5pB-5uhkA:
undetectable		 3n5pA-5uhkA:
21.09
3n5pB-5uhkA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYL_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5uhk O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		4 / 7 ARG A  84
TRP A  73
PHE A 318
GLU A 317
 None
 1.45A 3tylA-5uhkA:
undetectable
3tylB-5uhkA:
undetectable		 3tylA-5uhkA:
22.30
3tylB-5uhkA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTW_B_H4BB1720_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5uhk O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		4 / 7 TRP A  73
PHE A 318
GLU A 317
ARG A  84
 None
 1.48A 4ctwA-5uhkA:
undetectable
4ctwB-5uhkA:
undetectable		 4ctwA-5uhkA:
22.30
4ctwB-5uhkA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_ACTA860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5uhk O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		4 / 5 GLY A 251
ILE A 264
VAL A 228
SER A 263
 None
 1.24A 4d33A-5uhkA:
undetectable		 4d33A-5uhkA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5uhk O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		4 / 5 GLY A 251
ILE A 264
VAL A 228
SER A 263
 None
 1.25A 4d33B-5uhkA:
undetectable		 4d33B-5uhkA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_B_0LAB602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 5uhk O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		4 / 6 LEU A 158
LEU A 154
ILE A 143
THR A 199
 None
 0.98A 4do3B-5uhkA:
undetectable		 4do3B-5uhkA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSF_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5uhk O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		4 / 7 ARG A  84
TRP A  73
PHE A 318
GLU A 317
 None
 1.46A 4jsfA-5uhkA:
undetectable
4jsfB-5uhkA:
undetectable		 4jsfA-5uhkA:
22.30
4jsfB-5uhkA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5G_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5uhk O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		4 / 7 TRP A  73
PHE A 318
GLU A 317
ARG A  84
 None
 1.46A 4k5gA-5uhkA:
undetectable
4k5gB-5uhkA:
undetectable		 4k5gA-5uhkA:
22.30
4k5gB-5uhkA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5uhk O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		4 / 7 TRP A  73
PHE A 318
GLU A 317
ARG A  84
 None
 1.45A 4kcnA-5uhkA:
undetectable
4kcnB-5uhkA:
0.5		 4kcnA-5uhkA:
22.30
4kcnB-5uhkA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCS_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5uhk O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		4 / 6 TRP A  73
PHE A 318
GLU A 317
ARG A  84
 None
 1.48A 4kcsA-5uhkA:
undetectable
4kcsB-5uhkA:
undetectable		 4kcsA-5uhkA:
21.01
4kcsB-5uhkA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UGZ_B_H4BB760_1
(NEURONAL NITRIC
OXIDE SYNTHASE)		 5uhk O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		4 / 7 TRP A  73
PHE A 318
GLU A 317
ARG A  84
 None
 1.44A 4ugzA-5uhkA:
undetectable
4ugzB-5uhkA:
undetectable		 4ugzA-5uhkA:
22.30
4ugzB-5uhkA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		 5uhk O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		5 / 12 ASN A 147
SER A 146
ASP A 184
ILE A 143
PRO A 139
 None
 1.36A 4uroA-5uhkA:
undetectable		 4uroA-5uhkA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		 5uhk O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		5 / 12 ASN A 147
SER A 146
ASP A 184
ILE A 143
PRO A 139
 None
 1.38A 4uroD-5uhkA:
undetectable		 4uroD-5uhkA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_2
(ESTROGEN RECEPTOR)		 5uhk O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		4 / 6 LEU A  94
GLU A 132
ILE A 137
HIS A 103
 None
 0.89A 4xi3C-5uhkA:
undetectable		 4xi3C-5uhkA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_I_DIFI1006_1
(SERUM ALBUMIN)		 5uhk O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		5 / 10 ARG A 104
PHE A 173
ARG A 108
LEU A 154
ILE A 198
 None
 1.24A 4z69I-5uhkA:
undetectable		 4z69I-5uhkA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5uhk O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		5 / 12 GLY A 221
PHE A 145
ILE A 198
PHE A 191
GLY A 140
 None
 1.08A 4zdyA-5uhkA:
undetectable		 4zdyA-5uhkA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDZ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5uhk O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		4 / 7 PHE A 145
ILE A 198
PHE A 191
GLY A 140
 None
 0.87A 4zdzA-5uhkA:
undetectable		 4zdzA-5uhkA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5uhk O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		5 / 12 GLY A 221
PHE A 145
ILE A 198
PHE A 191
GLY A 140
 None
 1.00A 4ze2A-5uhkA:
undetectable		 4ze2A-5uhkA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE3_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5uhk O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		4 / 7 PHE A 145
ILE A 198
PHE A 191
GLY A 140
 None
 0.87A 4ze3A-5uhkA:
undetectable		 4ze3A-5uhkA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AGK_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5uhk O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		4 / 7 TRP A  73
PHE A 318
GLU A 317
ARG A  84
 None
 1.44A 5agkA-5uhkA:
undetectable
5agkB-5uhkA:
undetectable		 5agkA-5uhkA:
22.30
5agkB-5uhkA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AGP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5uhk O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		4 / 7 TRP A  73
PHE A 318
GLU A 317
ARG A  84
 None
 1.46A 5agpA-5uhkA:
undetectable
5agpB-5uhkA:
undetectable		 5agpA-5uhkA:
22.30
5agpB-5uhkA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EQB_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5uhk O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		5 / 12 GLY A 221
PHE A 145
ILE A 198
PHE A 191
GLY A 140
 None
 1.08A 5eqbA-5uhkA:
undetectable		 5eqbA-5uhkA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5uhk O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		5 / 12 GLY A 221
PHE A 145
ILE A 198
PHE A 191
GLY A 140
 None
 1.03A 5eskA-5uhkA:
undetectable		 5eskA-5uhkA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5uhk O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		5 / 12 GLY A 221
PHE A 145
ILE A 198
PHE A 191
GLY A 140
 None
 1.02A 5eslA-5uhkA:
undetectable		 5eslA-5uhkA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESM_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5uhk O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		4 / 7 PHE A 145
ILE A 198
PHE A 191
GLY A 140
 None
 0.91A 5esmA-5uhkA:
undetectable		 5esmA-5uhkA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_2
(CYP51 VARIANT1)		 5uhk O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		3 / 3 PRO A 209
LEU A 171
SER A 168
 None
 0.85A 5fsaB-5uhkA:
undetectable		 5fsaB-5uhkA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0O_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5uhk O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		4 / 7 ARG A  84
TRP A  73
PHE A 318
GLU A 317
 None
 1.49A 5g0oA-5uhkA:
undetectable
5g0oB-5uhkA:
undetectable		 5g0oA-5uhkA:
22.17
5g0oB-5uhkA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS1_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5uhk O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		4 / 8 PHE A 145
ILE A 198
PHE A 191
GLY A 140
 None
 0.84A 5hs1A-5uhkA:
undetectable		 5hs1A-5uhkA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_F_SAMF501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 5uhk O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		5 / 10 LEU A 248
PRO A 275
GLY A 251
VAL A 310
LEU A 311
 None
 1.02A 5o96E-5uhkA:
4.3
5o96F-5uhkA:
3.5		 5o96E-5uhkA:
23.68
5o96F-5uhkA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNT_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5uhk O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		4 / 7 TRP A  73
PHE A 318
GLU A 317
ARG A  84
 None
 1.44A 5untA-5uhkA:
0.5
5untB-5uhkA:
undetectable		 5untA-5uhkA:
22.30
5untB-5uhkA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNU_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5uhk O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		4 / 7 TRP A  73
PHE A 318
GLU A 317
ARG A  84
 None
 1.38A 5unuA-5uhkA:
undetectable
5unuB-5uhkA:
undetectable		 5unuA-5uhkA:
22.30
5unuB-5uhkA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNV_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5uhk O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		4 / 6 TRP A  73
PHE A 318
GLU A 317
ARG A  84
 None
 1.43A 5unvA-5uhkA:
undetectable
5unvB-5uhkA:
0.1		 5unvA-5uhkA:
22.30
5unvB-5uhkA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO0_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5uhk O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		4 / 7 TRP A  73
PHE A 318
GLU A 317
ARG A  84
 None
 1.37A 5uo0A-5uhkA:
undetectable
5uo0B-5uhkA:
undetectable		 5uo0A-5uhkA:
22.30
5uo0B-5uhkA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5uhk O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		4 / 7 ARG A  84
TRP A  73
PHE A 318
GLU A 317
 None
 1.48A 5vuoA-5uhkA:
0.5
5vuoB-5uhkA:
undetectable		 5vuoA-5uhkA:
22.30
5vuoB-5uhkA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5uhk O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		4 / 7 TRP A  73
PHE A 318
GLU A 317
ARG A  84
 None
 1.44A 5vuoA-5uhkA:
0.5
5vuoB-5uhkA:
undetectable		 5vuoA-5uhkA:
22.30
5vuoB-5uhkA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUQ_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5uhk O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		4 / 7 TRP A  73
PHE A 318
GLU A 317
ARG A  84
 None
 1.45A 5vuqA-5uhkA:
undetectable
5vuqB-5uhkA:
undetectable		 5vuqA-5uhkA:
22.30
5vuqB-5uhkA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUR_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5uhk O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		4 / 7 TRP A  73
PHE A 318
GLU A 317
ARG A  84
 None
 1.39A 5vurA-5uhkA:
0.6
5vurB-5uhkA:
undetectable		 5vurA-5uhkA:
22.30
5vurB-5uhkA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUT_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5uhk O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		4 / 7 TRP A  73
PHE A 318
GLU A 317
ARG A  84
 None
 1.44A 5vutA-5uhkA:
undetectable
5vutB-5uhkA:
undetectable		 5vutA-5uhkA:
22.30
5vutB-5uhkA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV1_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5uhk O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		4 / 6 ARG A  84
TRP A  73
PHE A 318
GLU A 317
 None
 1.44A 5vv1A-5uhkA:
undetectable
5vv1B-5uhkA:
undetectable		 5vv1A-5uhkA:
21.65
5vv1B-5uhkA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV8_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5uhk O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		4 / 6 ARG A  84
TRP A  73
PHE A 318
GLU A 317
 None
 1.46A 5vv8A-5uhkA:
undetectable
5vv8B-5uhkA:
undetectable		 5vv8A-5uhkA:
21.01
5vv8B-5uhkA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVN_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5uhk O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		4 / 6 ARG A  84
TRP A  73
PHE A 318
GLU A 317
 None
 1.49A 5vvnA-5uhkA:
undetectable
5vvnB-5uhkA:
undetectable		 5vvnA-5uhkA:
21.01
5vvnB-5uhkA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5uhk O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		5 / 12 PHE A  60
LEU A 248
ILE A 134
LEU A 328
TYR A 296
 None
 1.45A 5ycpA-5uhkA:
undetectable		 5ycpA-5uhkA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUQ_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5uhk O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		4 / 7 TRP A  73
PHE A 318
GLU A 317
ARG A  84
 None
 1.41A 6auqA-5uhkA:
undetectable
6auqB-5uhkA:
undetectable		 6auqA-5uhkA:
12.17
6auqB-5uhkA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUT_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5uhk O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		4 / 7 TRP A  73
PHE A 318
GLU A 317
ARG A  84
 None
 1.47A 6autA-5uhkA:
undetectable
6autB-5uhkA:
undetectable		 6autA-5uhkA:
12.17
6autB-5uhkA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV1_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5uhk O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		4 / 7 TRP A  73
PHE A 318
GLU A 317
ARG A  84
 None
 1.41A 6av1A-5uhkA:
undetectable
6av1B-5uhkA:
undetectable		 6av1A-5uhkA:
13.33
6av1B-5uhkA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CID_A_H4BA802_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5uhk O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		4 / 7 ARG A  84
TRP A  73
PHE A 318
GLU A 317
 None
 1.46A 6cidA-5uhkA:
undetectable
6cidB-5uhkA:
undetectable		 6cidA-5uhkA:
13.33
6cidB-5uhkA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E8Q_A_X2NA602_0
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5uhk O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		5 / 12 GLY A 221
PHE A 145
ILE A 198
PHE A 191
GLY A 140
 None
 1.01A 6e8qA-5uhkA:
undetectable		 6e8qA-5uhkA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA605_0
(SERUM ALBUMIN)		 5uhk O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		4 / 8 GLY A 309
GLY A  63
LEU A 311
GLU A 132
 None
 0.86A 6mdqA-5uhkA:
undetectable		 6mdqA-5uhkA:
15.86