SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5uhp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_B_NIOB702_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5uhp O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		4 / 5 PHE A 145
GLY A 140
THR A 217
PHE A 173
 None
 1.38A 1icvA-5uhpA:
undetectable
1icvB-5uhpA:
undetectable		 1icvA-5uhpA:
20.05
1icvB-5uhpA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1868_0
(FPRA)		 5uhp O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		3 / 3 ALA A 192
HIS A 193
VAL A 196
 None
 0.40A 1lqtB-5uhpA:
undetectable		 1lqtB-5uhpA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1425_0
(FPRA)		 5uhp O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		3 / 3 ALA A 192
HIS A 193
VAL A 196
 None
 0.41A 1lquB-5uhpA:
undetectable		 1lquB-5uhpA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MCN_P_DHIP1_0
(IMMUNOGLOBULIN
LAMBDA DIMER MCG
(LIGHT CHAIN)
PEPTIDE
N-ACETYL-D-HIS-L-PRO
-NH2)		 5uhp O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		3 / 3 PHE A 214
TYR A 233
PRO A 216
 None
 1.12A 1mcnA-5uhpA:
undetectable
1mcnB-5uhpA:
undetectable
1mcnP-5uhpA:
undetectable		 1mcnA-5uhpA:
21.48
1mcnB-5uhpA:
21.48
1mcnP-5uhpA:
1.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 5uhp O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		4 / 6 ARG A  83
TYR A  95
ASP A 100
GLU A  80
 None
 1.33A 1rjdA-5uhpA:
undetectable		 1rjdA-5uhpA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W4X_A_STZA1591_1
(O-GLCNACASE BT_4395)		 5uhp O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		10 / 11 ASP A 174
CYH A 215
TYR A 219
THR A 250
VAL A 254
TRP A 278
ASN A 280
ASP A 285
TYR A 286
ASN A 313
 GOL  A 501 (-2.5A)
GOL  A 501 ( 3.9A)
GOL  A 501 (-3.7A)
GOL  A 501 (-4.2A)
GOL  A 501 (-4.2A)
GOL  A 501 (-3.8A)
GOL  A 501 (-3.4A)
None
None
None
 0.57A 2w4xA-5uhpA:
34.3		 2w4xA-5uhpA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X0Y_A_X0TA1625_1
(O-GLCNACASE NAGJ)		 5uhp O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		8 / 12 ASP A 174
TYR A 219
THR A 250
VAL A 254
TRP A 278
ASN A 280
ASP A 285
ASN A 313
 GOL  A 501 (-2.5A)
GOL  A 501 (-3.7A)
GOL  A 501 (-4.2A)
GOL  A 501 (-4.2A)
GOL  A 501 (-3.8A)
GOL  A 501 (-3.4A)
None
None
 0.54A 2x0yA-5uhpA:
36.5		 2x0yA-5uhpA:
29.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X0Y_B_X0TB1625_1
(O-GLCNACASE NAGJ)		 5uhp O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		8 / 12 ASP A 174
TYR A 219
THR A 250
TRP A 278
ASN A 280
ASP A 285
TYR A 286
ASN A 313
 GOL  A 501 (-2.5A)
GOL  A 501 (-3.7A)
GOL  A 501 (-4.2A)
GOL  A 501 (-3.8A)
GOL  A 501 (-3.4A)
None
None
None
 0.54A 2x0yB-5uhpA:
35.0		 2x0yB-5uhpA:
29.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRH_A_NIOA200_1
(PROTEIN HP0721)		 5uhp O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		4 / 7 GLY A 238
ILE A 245
THR A 199
ARG A 273
 None
 1.01A 2xrhA-5uhpA:
undetectable		 2xrhA-5uhpA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_A_ACHA1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5uhp O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		4 / 6 TYR A 111
TYR A 135
TYR A  95
ILE A 123
 None
 1.38A 2xz5A-5uhpA:
undetectable
2xz5B-5uhpA:
undetectable		 2xz5A-5uhpA:
17.01
2xz5B-5uhpA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQT_C_C5EC301_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5uhp O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		4 / 8 TYR A 374
CYH A  62
TYR A 296
ILE A 304
 None
 1.30A 4bqtC-5uhpA:
undetectable
4bqtD-5uhpA:
undetectable		 4bqtC-5uhpA:
17.01
4bqtD-5uhpA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_ACTA860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5uhp O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		4 / 5 GLY A 251
ILE A 264
VAL A 228
SER A 263
 None
 1.02A 4d33A-5uhpA:
undetectable		 4d33A-5uhpA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5uhp O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		4 / 5 GLY A 251
ILE A 264
VAL A 228
SER A 263
 None
 1.05A 4d33B-5uhpA:
undetectable		 4d33B-5uhpA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5uhp O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		4 / 6 GLY A 251
ILE A 264
VAL A 228
SER A 263
 None
 1.06A 4d39B-5uhpA:
undetectable		 4d39B-5uhpA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D3A_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5uhp O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		4 / 6 ARG A  84
TRP A  73
PHE A 318
GLU A 317
 None
 1.48A 4d3aA-5uhpA:
undetectable
4d3aB-5uhpA:
undetectable		 4d3aA-5uhpA:
20.89
4d3aB-5uhpA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_B_0LAB602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 5uhp O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		4 / 6 LEU A 158
LEU A 154
ILE A 143
THR A 199
 None
 0.94A 4do3B-5uhpA:
undetectable		 4do3B-5uhpA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMT_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5uhp O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		4 / 7 TRP A  73
PHE A 318
GLU A 317
ARG A  84
 None
 1.49A 4imtA-5uhpA:
0.2
4imtB-5uhpA:
undetectable		 4imtA-5uhpA:
20.00
4imtB-5uhpA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSH_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5uhp O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		4 / 6 TRP A  73
PHE A 318
GLU A 317
ARG A  84
 None
 1.48A 4jshA-5uhpA:
undetectable
4jshB-5uhpA:
undetectable		 4jshA-5uhpA:
20.00
4jshB-5uhpA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		 5uhp O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		5 / 12 ASN A 147
SER A 146
ASP A 184
ILE A 143
PRO A 139
 None
 1.36A 4uroA-5uhpA:
undetectable		 4uroA-5uhpA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		 5uhp O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		5 / 12 ASN A 147
SER A 146
ASP A 184
ILE A 143
PRO A 139
 None
 1.38A 4uroB-5uhpA:
undetectable		 4uroB-5uhpA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		 5uhp O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		5 / 12 ASN A 147
SER A 146
ASP A 184
ILE A 143
PRO A 139
 None
 1.36A 4uroD-5uhpA:
undetectable		 4uroD-5uhpA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3U_D_H4BD760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5uhp O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		4 / 7 TRP A  73
PHE A 318
GLU A 317
ARG A  84
 None
 1.49A 4v3uC-5uhpA:
undetectable
4v3uD-5uhpA:
undetectable		 4v3uC-5uhpA:
20.45
4v3uD-5uhpA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 5uhp O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		4 / 6 LYS A 308
LEU A  61
ASN A  91
ARG A 340
 None
 1.05A 4yv5B-5uhpA:
undetectable		 4yv5B-5uhpA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 5uhp O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		4 / 6 LYS A 308
LEU A  61
ASN A  91
ARG A 340
 None
 1.02A 4yv5A-5uhpA:
undetectable		 4yv5A-5uhpA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD4_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5uhp O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		4 / 7 TRP A  73
PHE A 318
GLU A 317
ARG A  84
 None
 1.49A 5ad4A-5uhpA:
undetectable
5ad4B-5uhpA:
0.3		 5ad4A-5uhpA:
20.00
5ad4B-5uhpA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADA_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5uhp O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		4 / 7 TRP A  73
PHE A 318
GLU A 317
ARG A  84
 None
 1.50A 5adaA-5uhpA:
undetectable
5adaB-5uhpA:
undetectable		 5adaA-5uhpA:
20.00
5adaB-5uhpA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADB_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5uhp O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		4 / 6 TRP A  73
PHE A 318
GLU A 317
ARG A  84
 None
 1.48A 5adbA-5uhpA:
undetectable
5adbB-5uhpA:
undetectable		 5adbA-5uhpA:
20.00
5adbB-5uhpA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADI_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5uhp O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		4 / 7 ARG A  84
TRP A  73
PHE A 318
GLU A 317
 None
 1.50A 5adiA-5uhpA:
undetectable
5adiB-5uhpA:
undetectable		 5adiA-5uhpA:
20.45
5adiB-5uhpA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5uhp O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		4 / 6 TRP A  73
PHE A 318
GLU A 317
ARG A  84
 None
 1.46A 5fvpA-5uhpA:
undetectable
5fvpB-5uhpA:
0.3		 5fvpA-5uhpA:
20.00
5fvpB-5uhpA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVU_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5uhp O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		4 / 7 TRP A  73
PHE A 318
GLU A 317
ARG A  84
 None
 1.50A 5fvuA-5uhpA:
0.0
5fvuB-5uhpA:
undetectable		 5fvuA-5uhpA:
20.45
5fvuB-5uhpA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5uhp O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		4 / 7 ILE A 271
GLY A 238
PHE A 145
PHE A 191
 None
 1.07A 5hieA-5uhpA:
undetectable		 5hieA-5uhpA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_F_SAMF501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 5uhp O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		5 / 10 LEU A 248
PRO A 275
GLY A 251
VAL A 310
LEU A 311
 None
 0.96A 5o96E-5uhpA:
3.0
5o96F-5uhpA:
3.4		 5o96E-5uhpA:
22.66
5o96F-5uhpA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNU_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5uhp O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		4 / 7 TRP A  73
PHE A 318
GLU A 317
ARG A  84
 None
 1.45A 5unuA-5uhpA:
undetectable
5unuB-5uhpA:
undetectable		 5unuA-5uhpA:
20.00
5unuB-5uhpA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNW_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5uhp O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		4 / 7 TRP A  73
PHE A 318
GLU A 317
ARG A  84
 None
 1.46A 5unwA-5uhpA:
undetectable
5unwB-5uhpA:
undetectable		 5unwA-5uhpA:
20.00
5unwB-5uhpA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNX_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5uhp O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		4 / 6 TRP A  73
PHE A 318
GLU A 317
ARG A  84
 None
 1.44A 5unxA-5uhpA:
undetectable
5unxB-5uhpA:
undetectable		 5unxA-5uhpA:
20.00
5unxB-5uhpA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNY_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5uhp O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		4 / 7 TRP A  73
PHE A 318
GLU A 317
ARG A  84
 None
 1.49A 5unyA-5uhpA:
undetectable
5unyB-5uhpA:
undetectable		 5unyA-5uhpA:
20.00
5unyB-5uhpA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNZ_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5uhp O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		4 / 7 TRP A  73
PHE A 318
GLU A 317
ARG A  84
 None
 1.48A 5unzA-5uhpA:
undetectable
5unzB-5uhpA:
undetectable		 5unzA-5uhpA:
20.00
5unzB-5uhpA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO0_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5uhp O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		4 / 7 TRP A  73
PHE A 318
GLU A 317
ARG A  84
 None
 1.45A 5uo0A-5uhpA:
undetectable
5uo0B-5uhpA:
undetectable		 5uo0A-5uhpA:
20.00
5uo0B-5uhpA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO3_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5uhp O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		4 / 7 ARG A  84
TRP A  73
PHE A 318
GLU A 317
 None
 1.47A 5uo3A-5uhpA:
0.3
5uo3B-5uhpA:
undetectable		 5uo3A-5uhpA:
20.45
5uo3B-5uhpA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO9_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5uhp O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		4 / 7 TRP A  73
PHE A 318
GLU A 317
ARG A  84
 None
 1.50A 5uo9C-5uhpA:
undetectable
5uo9D-5uhpA:
undetectable		 5uo9C-5uhpA:
23.16
5uo9D-5uhpA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUJ_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5uhp O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		4 / 7 TRP A  73
PHE A 318
GLU A 317
ARG A  84
 None
 1.50A 5vujA-5uhpA:
0.6
5vujB-5uhpA:
undetectable		 5vujA-5uhpA:
20.00
5vujB-5uhpA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUK_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5uhp O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		4 / 7 TRP A  73
PHE A 318
GLU A 317
ARG A  84
 None
 1.49A 5vukA-5uhpA:
0.0
5vukB-5uhpA:
undetectable		 5vukA-5uhpA:
20.00
5vukB-5uhpA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUR_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5uhp O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		4 / 7 TRP A  73
PHE A 318
GLU A 317
ARG A  84
 None
 1.47A 5vurA-5uhpA:
0.6
5vurB-5uhpA:
undetectable		 5vurA-5uhpA:
20.00
5vurB-5uhpA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUQ_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5uhp O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		4 / 7 TRP A  73
PHE A 318
GLU A 317
ARG A  84
 None
 1.48A 6auqA-5uhpA:
undetectable
6auqB-5uhpA:
undetectable		 6auqA-5uhpA:
11.08
6auqB-5uhpA:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5uhp O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		4 / 7 TRP A  73
PHE A 318
GLU A 317
ARG A  84
 None
 1.49A 6auuA-5uhpA:
undetectable
6auuB-5uhpA:
undetectable		 6auuA-5uhpA:
11.08
6auuB-5uhpA:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV1_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5uhp O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		4 / 7 TRP A  73
PHE A 318
GLU A 317
ARG A  84
 None
 1.48A 6av1A-5uhpA:
undetectable
6av1B-5uhpA:
undetectable		 6av1A-5uhpA:
12.11
6av1B-5uhpA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5uhp O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		4 / 7 TRP A  73
PHE A 318
GLU A 317
ARG A  84
 None
 1.42A 6av6C-5uhpA:
undetectable
6av6D-5uhpA:
undetectable		 6av6C-5uhpA:
12.37
6av6D-5uhpA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIE_D_H4BD502_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5uhp O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens) 		4 / 6 TRP A  73
PHE A 318
GLU A 317
ARG A  84
 None
 1.50A 6cieC-5uhpA:
undetectable
6cieD-5uhpA:
0.0		 6cieC-5uhpA:
12.37
6cieD-5uhpA:
12.37