SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5uhu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4007_1
(SERUM ALBUMIN)		 5uhu MYCINAMICIN IV
HYDROXYLASE/EPOXIDAS
E
(Micromonospora
griseorubida) 		4 / 8 LEU A  94
HIS A  91
LEU A 347
LEU A  83
 None
HEM  A 401 (-3.9A)
HEM  A 401 (-3.2A)
HEM  A 401 (-3.4A)
 0.84A 1e7cA-5uhuA:
undetectable		 1e7cA-5uhuA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3004_1
(SERUM ALBUMIN)		 5uhu MYCINAMICIN IV
HYDROXYLASE/EPOXIDAS
E
(Micromonospora
griseorubida) 		4 / 7 PHE A  61
LEU A 296
VAL A  46
LEU A  56
 None
 1.00A 1hk3A-5uhuA:
2.5		 1hk3A-5uhuA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_H_AG2H7012_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 5uhu MYCINAMICIN IV
HYDROXYLASE/EPOXIDAS
E
(Micromonospora
griseorubida) 		4 / 6 GLU A 355
LEU A 351
LEU A 151
GLY A 152
 None
HEM  A 401 ( 4.2A)
None
None
 0.95A 1n13H-5uhuA:
undetectable
1n13K-5uhuA:
undetectable		 1n13H-5uhuA:
13.60
1n13K-5uhuA:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_B_ADNB1502_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 5uhu MYCINAMICIN IV
HYDROXYLASE/EPOXIDAS
E
(Micromonospora
griseorubida) 		4 / 7 ARG A  69
GLU A  71
PRO A  72
ALA A  43
 None
 1.21A 2ejgB-5uhuA:
undetectable		 2ejgB-5uhuA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 5uhu MYCINAMICIN IV
HYDROXYLASE/EPOXIDAS
E
(Micromonospora
griseorubida) 		5 / 12 ALA A 208
LEU A 205
LEU A 224
LEU A  94
ARG A  93
 None
 1.16A 2oipA-5uhuA:
undetectable		 2oipA-5uhuA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 5uhu MYCINAMICIN IV
HYDROXYLASE/EPOXIDAS
E
(Micromonospora
griseorubida) 		5 / 12 ASN A 315
GLY A 340
GLY A 338
LEU A  56
TYR A  49
 None
 1.26A 2zw9A-5uhuA:
undetectable		 2zw9A-5uhuA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_2
(PROTEASE)		 5uhu MYCINAMICIN IV
HYDROXYLASE/EPOXIDAS
E
(Micromonospora
griseorubida) 		3 / 3 ARG A  63
VAL A 282
THR A  74
 None
 0.81A 3ndtA-5uhuA:
undetectable		 3ndtA-5uhuA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_B_TPVB100_1
(HIV-1 PROTEASE)		 5uhu MYCINAMICIN IV
HYDROXYLASE/EPOXIDAS
E
(Micromonospora
griseorubida) 		5 / 9 LEU A  45
ALA A 285
VAL A  52
GLY A 338
THR A  47
 None
HEM  A 401 (-3.6A)
None
None
None
 1.16A 3spkA-5uhuA:
undetectable		 3spkA-5uhuA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB603_1
(SERUM ALBUMIN)		 5uhu MYCINAMICIN IV
HYDROXYLASE/EPOXIDAS
E
(Micromonospora
griseorubida) 		5 / 11 LEU A 231
VAL A 146
LEU A 110
LEU A 232
LEU A 205
 HEM  A 401 (-3.4A)
None
None
None
None
 1.30A 4or0B-5uhuA:
undetectable		 4or0B-5uhuA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2D_F_LFXF102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 5uhu MYCINAMICIN IV
HYDROXYLASE/EPOXIDAS
E
(Micromonospora
griseorubida) 		3 / 4 ARG A 302
GLY A 304
GLU A 305
 None
 0.65A 4z2dB-5uhuA:
undetectable
4z2dC-5uhuA:
undetectable		 4z2dB-5uhuA:
22.14
4z2dC-5uhuA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J6H_A_NCAA402_0
(H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, Q10 ALPHA
CHAIN)		 5uhu MYCINAMICIN IV
HYDROXYLASE/EPOXIDAS
E
(Micromonospora
griseorubida) 		3 / 3 PRO A 287
ARG A 288
GLU A  71
 None
HEM  A 401 (-3.0A)
None
 0.94A 5j6hA-5uhuA:
undetectable		 5j6hA-5uhuA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB306_0
(WELO5)		 5uhu MYCINAMICIN IV
HYDROXYLASE/EPOXIDAS
E
(Micromonospora
griseorubida) 		3 / 3 GLU A  50
ARG A  53
TYR A  49
 None
 0.60A 5trqB-5uhuA:
undetectable		 5trqB-5uhuA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DYO_A_LDPA901_0
(EBONY)		 5uhu MYCINAMICIN IV
HYDROXYLASE/EPOXIDAS
E
(Micromonospora
griseorubida) 		4 / 5 GLU A  71
VAL A  79
LEU A  84
HIS A  91
 None
MIV  A 402 (-3.1A)
HEM  A 401 (-3.4A)
HEM  A 401 (-3.9A)
 1.36A 6dyoA-5uhuA:
undetectable		 6dyoA-5uhuA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GQI_A_ACTA604_0
(CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE)		 5uhu MYCINAMICIN IV
HYDROXYLASE/EPOXIDAS
E
(Micromonospora
griseorubida) 		4 / 6 PRO A  37
GLY A  40
TYR A  39
GLU A  71
 None
 1.09A 6gqiA-5uhuA:
undetectable		 6gqiA-5uhuA:
23.69