SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5uic'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_B_CCSB47_0
(GLUTATHIONE
S-TRANSFERASE)		 5uic TWO-COMPONENT
RESPONSE REGULATOR
(Francisella
tularensis) 		4 / 7 LEU A 108
LEU A  17
GLY A  15
LEU A  12
 None
 0.94A 1gtiB-5uicA:
undetectable		 1gtiB-5uicA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_B_DZPB2001_1
(SERUM ALBUMIN)		 5uic TWO-COMPONENT
RESPONSE REGULATOR
(Francisella
tularensis) 		5 / 12 LEU A 105
LEU A  29
VAL A  27
GLU A  18
LEU A  17
 None
 1.30A 2bxfB-5uicA:
undetectable		 2bxfB-5uicA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_C_478C200_2
(PROTEASE)		 5uic TWO-COMPONENT
RESPONSE REGULATOR
(Francisella
tularensis) 		6 / 10 LEU A  60
GLY A  94
ALA A  95
ASP A  97
ILE A  76
ILE A  40
 None
 1.42A 3ekpD-5uicA:
undetectable		 3ekpD-5uicA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_1
(PROTEASE)		 5uic TWO-COMPONENT
RESPONSE REGULATOR
(Francisella
tularensis) 		4 / 8 GLY A  94
ALA A  95
ASP A  96
THR A  79
 None
 0.54A 3el0A-5uicA:
undetectable		 3el0A-5uicA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 5uic TWO-COMPONENT
RESPONSE REGULATOR
(Francisella
tularensis) 		5 / 12 ILE A  75
VAL A  73
ILE A  71
ASN A  68
ILE A  66
 None
 1.19A 3kpdB-5uicA:
undetectable		 3kpdB-5uicA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_A_ADNA401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 5uic TWO-COMPONENT
RESPONSE REGULATOR
(Francisella
tularensis) 		5 / 12 ILE A  76
VAL A  73
LEU A   5
ALA A   6
LEU A  16
 None
 1.02A 6bq4A-5uicA:
3.5		 6bq4A-5uicA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_2
(TUBULIN BETA CHAIN)		 5uic TWO-COMPONENT
RESPONSE REGULATOR
(Francisella
tularensis) 		4 / 5 LEU A 108
LEU A  12
THR A  79
PRO A  55
 None
 1.06A 6ew0F-5uicA:
undetectable		 6ew0F-5uicA:
19.59