SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5uid'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Z_B_ROCB505_1
(PROTEIN (PROTEASE))		 5uid AMINOTRANSFERASE
TLMJ
(Streptoalloteich
us
hindustanus) 		5 / 12 GLY A  95
ALA A  96
VAL A  77
GLY A  70
ILE A  91
 None
 0.97A 1c6zA-5uidA:
undetectable		 1c6zA-5uidA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7W_A_MTXA301_1
(PTERIDINE REDUCTASE)		 5uid AMINOTRANSFERASE
TLMJ
(Streptoalloteich
us
hindustanus) 		5 / 12 ARG A 266
PHE A 299
TYR A 327
TYR A 131
MET A 183
 LLP  A 184 ( 4.7A)
None
LLP  A 184 ( 4.3A)
None
None
 1.34A 1e7wA-5uidA:
undetectable		 1e7wA-5uidA:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_B_MTXB352_1
(PTERIDINE REDUCTASE
1)		 5uid AMINOTRANSFERASE
TLMJ
(Streptoalloteich
us
hindustanus) 		5 / 12 ARG A 266
PHE A 299
TYR A 327
TYR A 131
MET A 183
 LLP  A 184 ( 4.7A)
None
LLP  A 184 ( 4.3A)
None
None
 1.37A 1p33B-5uidA:
undetectable		 1p33B-5uidA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_D_MTXD354_1
(PTERIDINE REDUCTASE
1)		 5uid AMINOTRANSFERASE
TLMJ
(Streptoalloteich
us
hindustanus) 		5 / 12 ARG A 266
PHE A 299
TYR A 327
TYR A 131
MET A 183
 LLP  A 184 ( 4.7A)
None
LLP  A 184 ( 4.3A)
None
None
 1.41A 1p33D-5uidA:
3.2		 1p33D-5uidA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_2
(DIPEPTIDYL PEPTIDASE
IV)		 5uid AMINOTRANSFERASE
TLMJ
(Streptoalloteich
us
hindustanus) 		3 / 3 PHE A   7
TYR A 327
TYR A 131
 None
LLP  A 184 ( 4.3A)
None
 0.95A 1x70B-5uidA:
undetectable		 1x70B-5uidA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1321_0
(CHLOROPEROXIDASE)		 5uid AMINOTRANSFERASE
TLMJ
(Streptoalloteich
us
hindustanus) 		4 / 5 LEU A  64
PHE A 196
VAL A  55
ALA A 209
 None
 1.07A 2cizA-5uidA:
undetectable		 2cizA-5uidA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_4
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 5uid AMINOTRANSFERASE
TLMJ
(Streptoalloteich
us
hindustanus) 		4 / 5 ALA A  42
ALA A 202
ALA A 205
VAL A  55
 None
 0.71A 2nyrB-5uidA:
undetectable		 2nyrB-5uidA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5uid AMINOTRANSFERASE
TLMJ
(Streptoalloteich
us
hindustanus) 		4 / 6 ARG A 167
GLU A 143
ASP A 174
ARG A 197
 None
 1.39A 4kcnB-5uidA:
undetectable		 4kcnB-5uidA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5uid AMINOTRANSFERASE
TLMJ
(Streptoalloteich
us
hindustanus) 		5 / 12 GLY A  61
ALA A 125
ILE A  91
VAL A 127
VAL A 153
 None
 1.00A 4nkxC-5uidA:
undetectable		 4nkxC-5uidA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_A_SAMA1546_0
(CYSTATHIONINE
BETA-SYNTHASE)		 5uid AMINOTRANSFERASE
TLMJ
(Streptoalloteich
us
hindustanus) 		5 / 11 LEU A 172
ASP A 137
ALA A 142
HIS A 114
VAL A 128
 None
 1.40A 4uuuA-5uidA:
undetectable
4uuuB-5uidA:
undetectable		 4uuuA-5uidA:
17.91
4uuuB-5uidA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V20_A_ACTA1444_0
(CELLOBIOHYDROLASE)		 5uid AMINOTRANSFERASE
TLMJ
(Streptoalloteich
us
hindustanus) 		4 / 5 GLY A 170
THR A 171
HIS A 130
GLU A 154
 None
 0.91A 4v20A-5uidA:
undetectable		 4v20A-5uidA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_0
(REGULATORY PROTEIN
TETR)		 5uid AMINOTRANSFERASE
TLMJ
(Streptoalloteich
us
hindustanus) 		5 / 12 MET A 312
ALA A 375
LEU A 380
TYR A 300
VAL A 280
 None
 1.46A 5vlmC-5uidA:
undetectable		 5vlmC-5uidA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA502_1
(CYTOCHROME P450 2C9)		 5uid AMINOTRANSFERASE
TLMJ
(Streptoalloteich
us
hindustanus) 		5 / 12 ALA A  87
PHE A  63
VAL A  77
VAL A  71
GLY A  95
 None
 1.15A 5x24A-5uidA:
undetectable		 5x24A-5uidA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA503_1
(CYTOCHROME P450 2C9)		 5uid AMINOTRANSFERASE
TLMJ
(Streptoalloteich
us
hindustanus) 		5 / 12 PHE A   7
LEU A 353
THR A 352
LEU A 108
PHE A 325
 None
 1.28A 5xxiA-5uidA:
undetectable		 5xxiA-5uidA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA816_0
(UNCHARACTERIZED
PROTEIN)		 5uid AMINOTRANSFERASE
TLMJ
(Streptoalloteich
us
hindustanus) 		3 / 3 ARG A 314
ARG A 309
ASP A 310
 None
 0.98A 6d8pA-5uidA:
undetectable		 6d8pA-5uidA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_1
(TUBULIN BETA CHAIN)		 5uid AMINOTRANSFERASE
TLMJ
(Streptoalloteich
us
hindustanus) 		5 / 12 ALA A 159
SER A 296
ARG A 197
GLN A  51
LEU A  45
 None
 1.09A 6ew0B-5uidA:
undetectable		 6ew0B-5uidA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_1
(TUBULIN BETA CHAIN)		 5uid AMINOTRANSFERASE
TLMJ
(Streptoalloteich
us
hindustanus) 		5 / 12 ALA A 159
SER A 296
ARG A 197
GLN A  51
LEU A  45
 None
 1.09A 6ew0D-5uidA:
undetectable		 6ew0D-5uidA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_1
(TUBULIN BETA CHAIN)		 5uid AMINOTRANSFERASE
TLMJ
(Streptoalloteich
us
hindustanus) 		5 / 12 ALA A 159
SER A 296
ARG A 197
GLN A  51
LEU A  45
 None
 1.09A 6ew0F-5uidA:
undetectable		 6ew0F-5uidA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_1
(TUBULIN BETA CHAIN)		 5uid AMINOTRANSFERASE
TLMJ
(Streptoalloteich
us
hindustanus) 		5 / 12 ALA A 159
SER A 296
ARG A 197
GLN A  51
LEU A  45
 None
 1.09A 6ew0G-5uidA:
undetectable		 6ew0G-5uidA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_1
(TUBULIN BETA CHAIN)		 5uid AMINOTRANSFERASE
TLMJ
(Streptoalloteich
us
hindustanus) 		5 / 12 ALA A 159
SER A 296
ARG A 197
GLN A  51
LEU A  45
 None
 1.08A 6ew0H-5uidA:
undetectable		 6ew0H-5uidA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_1
(TUBULIN BETA CHAIN)		 5uid AMINOTRANSFERASE
TLMJ
(Streptoalloteich
us
hindustanus) 		5 / 12 ALA A 159
SER A 296
ARG A 197
GLN A  51
LEU A  45
 None
 1.08A 6ew0I-5uidA:
undetectable		 6ew0I-5uidA:
12.28