SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5uin'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_A_RBFA100_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 5uin FORMYLTRANSFERASE
(Salmonella
enterica) 		5 / 11 LEU A 122
THR A 121
ILE A   5
ILE A  11
VAL A  15
 None
 1.11A 1pkvA-5uinA:
undetectable
1pkvB-5uinA:
undetectable		 1pkvA-5uinA:
15.92
1pkvB-5uinA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_B_RBFB101_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 5uin FORMYLTRANSFERASE
(Salmonella
enterica) 		5 / 11 ILE A  11
VAL A  15
LEU A 122
THR A 121
ILE A   5
 None
 1.10A 1pkvA-5uinA:
undetectable
1pkvB-5uinA:
undetectable		 1pkvA-5uinA:
15.92
1pkvB-5uinA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RI4_A_SAMA299_0
(MRNA CAPPING ENZYME)		 5uin FORMYLTRANSFERASE
(Salmonella
enterica) 		5 / 12 LYS A 149
GLY A 304
ASP A 371
TYR A 372
PHE A  42
 None
 1.21A 1ri4A-5uinA:
undetectable		 1ri4A-5uinA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SKX_A_RFPA1_2
(ORPHAN NUCLEAR
RECEPTOR PXR)		 5uin FORMYLTRANSFERASE
(Salmonella
enterica) 		4 / 5 LYS A 280
PHE A 298
LEU A 276
LEU A 363
 None
 1.45A 1skxA-5uinA:
undetectable		 1skxA-5uinA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_D_NFZD4219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5uin FORMYLTRANSFERASE
(Salmonella
enterica) 		4 / 8 THR A 117
ASN A 211
GLU A 115
GLY A 114
 None
 1.10A 1ykiC-5uinA:
undetectable
1ykiD-5uinA:
undetectable		 1ykiC-5uinA:
18.59
1ykiD-5uinA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_A_PNTA901_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 5uin FORMYLTRANSFERASE
(Salmonella
enterica) 		5 / 12 ASP A  10
TYR A 372
GLY A  38
TYR A 335
ASN A 334
 None
 1.20A 3hiiA-5uinA:
undetectable		 3hiiA-5uinA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD202_1
(PROTEIN S100-A4)		 5uin FORMYLTRANSFERASE
(Salmonella
enterica) 		5 / 11 LEU A 297
SER A 295
ILE A 275
PHE A 232
ASP A 235
 None
 1.28A 3ko0C-5uinA:
undetectable
3ko0D-5uinA:
undetectable
3ko0E-5uinA:
undetectable
3ko0F-5uinA:
undetectable		 3ko0C-5uinA:
13.03
3ko0D-5uinA:
13.03
3ko0E-5uinA:
13.03
3ko0F-5uinA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE202_1
(PROTEIN S100-A4)		 5uin FORMYLTRANSFERASE
(Salmonella
enterica) 		5 / 11 ASP A 235
PHE A 232
LEU A 297
SER A 295
ILE A 275
 None
 1.32A 3ko0C-5uinA:
undetectable
3ko0D-5uinA:
undetectable
3ko0E-5uinA:
undetectable
3ko0F-5uinA:
undetectable		 3ko0C-5uinA:
13.03
3ko0D-5uinA:
13.03
3ko0E-5uinA:
13.03
3ko0F-5uinA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_F_TFPF202_1
(PROTEIN S100-A4)		 5uin FORMYLTRANSFERASE
(Salmonella
enterica) 		5 / 11 LEU A 297
SER A 295
ILE A 275
PHE A 232
ASP A 235
 None
 1.22A 3ko0E-5uinA:
undetectable
3ko0F-5uinA:
undetectable
3ko0G-5uinA:
undetectable
3ko0H-5uinA:
undetectable		 3ko0E-5uinA:
13.03
3ko0F-5uinA:
13.03
3ko0G-5uinA:
13.03
3ko0H-5uinA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_H_TFPH202_1
(PROTEIN S100-A4)		 5uin FORMYLTRANSFERASE
(Salmonella
enterica) 		5 / 12 LEU A 297
SER A 295
ILE A 275
PHE A 232
ASP A 235
 None
 1.24A 3ko0G-5uinA:
undetectable
3ko0H-5uinA:
undetectable
3ko0I-5uinA:
undetectable
3ko0J-5uinA:
undetectable		 3ko0G-5uinA:
13.03
3ko0H-5uinA:
13.03
3ko0I-5uinA:
13.03
3ko0J-5uinA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_Q_TFPQ202_1
(PROTEIN S100-A4)		 5uin FORMYLTRANSFERASE
(Salmonella
enterica) 		5 / 10 PHE A 232
ASP A 235
LEU A 297
SER A 295
ILE A 275
 None
 1.29A 3ko0O-5uinA:
undetectable
3ko0P-5uinA:
0.7
3ko0Q-5uinA:
undetectable
3ko0R-5uinA:
undetectable		 3ko0O-5uinA:
13.03
3ko0P-5uinA:
13.03
3ko0Q-5uinA:
13.03
3ko0R-5uinA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KUK_A_RBFA201_2
(BLUE-LIGHT
PHOTORECEPTOR)		 5uin FORMYLTRANSFERASE
(Salmonella
enterica) 		5 / 9 MET A 348
VAL A 308
ILE A 320
ILE A 330
GLY A 356
 None
 1.08A 4kukA-5uinA:
undetectable		 4kukA-5uinA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_B_ML1B302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5uin FORMYLTRANSFERASE
(Salmonella
enterica) 		4 / 6 GLY A   7
PHE A  71
ILE A   4
PHE A  85
 None
 1.07A 4qogA-5uinA:
2.2
4qogB-5uinA:
4.1		 4qogA-5uinA:
18.75
4qogB-5uinA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTR_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 5uin FORMYLTRANSFERASE
(Salmonella
enterica) 		5 / 11 GLY A 304
ASP A  10
ILE A 156
ASN A   9
SER A 157
 None
 1.05A 4rtrA-5uinA:
3.1		 4rtrA-5uinA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_A_RTZA602_1
(CYTOCHROME P450 2D6)		 5uin FORMYLTRANSFERASE
(Salmonella
enterica) 		5 / 12 PHE A  85
LEU A  90
GLY A   7
LEU A  74
VAL A  15
 None
 1.00A 4wnwA-5uinA:
undetectable		 4wnwA-5uinA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 5uin FORMYLTRANSFERASE
(Salmonella
enterica) 		3 / 3 LYS A 124
ASP A 126
ILE A  93
 None
 0.89A 5kc4E-5uinA:
undetectable		 5kc4E-5uinA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_I_BEZI1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 5uin FORMYLTRANSFERASE
(Salmonella
enterica) 		3 / 3 SER A 189
TYR A 188
TYR A 187
 None
 0.76A 5lakA-5uinA:
undetectable
5lakI-5uinA:
undetectable		 5lakA-5uinA:
21.95
5lakI-5uinA:
1.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_J_BEZJ1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 5uin FORMYLTRANSFERASE
(Salmonella
enterica) 		3 / 3 SER A 189
TYR A 188
TYR A 187
 None
 0.73A 5lakC-5uinA:
undetectable
5lakJ-5uinA:
undetectable		 5lakC-5uinA:
21.95
5lakJ-5uinA:
1.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_B_CXQB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 5uin FORMYLTRANSFERASE
(Salmonella
enterica) 		4 / 6 VAL A 377
LEU A 367
LEU A 365
MET A 348
 None
 0.91A 6f6sA-5uinA:
undetectable
6f6sB-5uinA:
undetectable		 6f6sA-5uinA:
13.33
6f6sB-5uinA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 5uin FORMYLTRANSFERASE
(Salmonella
enterica) 		4 / 8 MET A 243
ILE A 242
VAL A 266
SER A 238
 None
 0.98A 6fbvC-5uinA:
undetectable		 6fbvC-5uinA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_B_ACTB207_0
(DUF1778
DOMAIN-CONTAINING
PROTEIN
N-ACETYLTRANSFERASE)		 5uin FORMYLTRANSFERASE
(Salmonella
enterica) 		4 / 6 LEU A 369
THR A 339
GLY A 337
ARG A 333
 None
 1.30A 6gtqB-5uinA:
undetectable
6gtqD-5uinA:
undetectable		 6gtqB-5uinA:
18.64
6gtqD-5uinA:
8.14