SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5uj0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4P_A_TPVA300_2
(PROTEASE)		 5uj0 POLYNUCLEOTIDE
KINASE
(Escherichia
virus
T4) 		5 / 9 LEU A 240
ALA A 201
VAL A 162
VAL A 209
ILE A 207
 None
 0.95A 2o4pB-5uj0A:
undetectable		 2o4pB-5uj0A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VNS_A_DVAA602_0
(NRPS ADENYLATION
PROTEIN CYTC1)		 5uj0 POLYNUCLEOTIDE
KINASE
(Escherichia
virus
T4) 		4 / 7 ASP A 278
GLY A 212
THR A 169
LYS A 258
 MG  A 401 (-2.7A)
BFD  A 165 ( 3.7A)
BFD  A 165 ( 3.6A)
BFD  A 165 ( 2.8A)
 1.06A 3vnsA-5uj0A:
3.6		 3vnsA-5uj0A:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA2)		 5uj0 POLYNUCLEOTIDE
KINASE
(Escherichia
virus
T4) 		4 / 6 ARG A 213
GLY A 177
ASP A 180
GLY A 175
 None
 1.05A 4koeA-5uj0A:
undetectable
4koeB-5uj0A:
undetectable
4koeC-5uj0A:
undetectable		 4koeA-5uj0A:
16.34
4koeB-5uj0A:
16.34
4koeC-5uj0A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XIW_B_AZMB402_1
(CARBONIC ANHYDRASE,
ALPHA TYPE)		 5uj0 POLYNUCLEOTIDE
KINASE
(Escherichia
virus
T4) 		5 / 12 VAL A 209
LEU A 170
THR A 169
VAL A 238
PRO A 239
 None
BFD  A 165 ( 3.5A)
BFD  A 165 ( 3.6A)
None
None
 1.04A 4xiwB-5uj0A:
undetectable
4xiwE-5uj0A:
undetectable		 4xiwB-5uj0A:
19.18
4xiwE-5uj0A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 5uj0 POLYNUCLEOTIDE
KINASE
(Escherichia
virus
T4) 		4 / 7 ARG A 213
GLY A 177
ASP A 180
GLY A 175
 None
 0.97A 4z53A-5uj0A:
undetectable
4z53B-5uj0A:
undetectable		 4z53A-5uj0A:
13.85
4z53B-5uj0A:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_B_AC2B301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 5uj0 POLYNUCLEOTIDE
KINASE
(Escherichia
virus
T4) 		5 / 10 GLY A 290
ALA A 275
VAL A 291
GLU A 292
ILE A 289
 None
 1.04A 5i3cB-5uj0A:
undetectable		 5i3cB-5uj0A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NKN_A_LOCA201_2
(NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN)		 5uj0 POLYNUCLEOTIDE
KINASE
(Escherichia
virus
T4) 		3 / 3 VAL A 232
LYS A 172
MET A 173
 None
 0.94A 5nknA-5uj0A:
undetectable		 5nknA-5uj0A:
17.93