SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5uj1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HA2_A_SWFA3001_1
(SERUM ALBUMIN)		 5uj1 DNA TOPOISOMERASE 1
(Mycobacterium
tuberculosis) 		5 / 11 ALA A 698
LEU A 693
LEU A 666
SER A 643
ILE A 644
 None
 1.07A 1ha2A-5uj1A:
undetectable		 1ha2A-5uj1A:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHS_A_CLMA999_0
(PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE))		 5uj1 DNA TOPOISOMERASE 1
(Mycobacterium
tuberculosis) 		6 / 12 VAL A  23
ILE A 141
ILE A 146
PHE A 138
VAL A  42
ARG A  30
 None
 1.11A 1qhsA-5uj1A:
undetectable		 1qhsA-5uj1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHS_A_CLMA999_0
(PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE))		 5uj1 DNA TOPOISOMERASE 1
(Mycobacterium
tuberculosis) 		6 / 12 VAL A  23
ILE A 141
ILE A 146
PHE A 138
VAL A  42
LEU A  36
 None
 1.30A 1qhsA-5uj1A:
undetectable		 1qhsA-5uj1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUV_A_VK3A4558_1
(PROTEIN YGIN)		 5uj1 DNA TOPOISOMERASE 1
(Mycobacterium
tuberculosis) 		4 / 7 TYR A 517
LEU A 526
TYR A 580
ILE A 544
 None
 1.18A 1tuvA-5uj1A:
undetectable		 1tuvA-5uj1A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2887_0
(AMINOMETHYLTRANSFERA
SE)		 5uj1 DNA TOPOISOMERASE 1
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 566
TYR A 549
VAL A 562
ASN A 642
TYR A 174
 None
 1.41A 1wopA-5uj1A:
undetectable		 1wopA-5uj1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_D_BEZD2385_0
(CES1 PROTEIN)		 5uj1 DNA TOPOISOMERASE 1
(Mycobacterium
tuberculosis) 		4 / 5 LEU A 289
LEU A 504
LEU A 222
LEU A 284
 None
 1.14A 1yajD-5uj1A:
2.8		 1yajD-5uj1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH8_A_VIBA1_1
(MAJOR PRION PROTEIN)		 5uj1 DNA TOPOISOMERASE 1
(Mycobacterium
tuberculosis) 		4 / 6 PRO A 394
ASP A 415
ASP A 416
TYR A 420
 None
 1.38A 2lh8A-5uj1A:
undetectable		 2lh8A-5uj1A:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_FFOA505_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5uj1 DNA TOPOISOMERASE 1
(Mycobacterium
tuberculosis) 		4 / 6 GLU A 369
TYR A 370
PHE A 464
PRO A 465
 None
 1.49A 2vmyA-5uj1A:
undetectable		 2vmyA-5uj1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI9_X_SAMX501_0
(UPF0217 PROTEIN
MJ1640)		 5uj1 DNA TOPOISOMERASE 1
(Mycobacterium
tuberculosis) 		5 / 9 LEU A 526
ILE A 531
GLY A 530
LEU A 522
SER A 521
 None
 0.94A 3ai9X-5uj1A:
undetectable		 3ai9X-5uj1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_B_SALB1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5uj1 DNA TOPOISOMERASE 1
(Mycobacterium
tuberculosis) 		4 / 8 LEU A  36
ARG A 147
ALA A 149
ALA A 148
 None
 1.03A 3ax9B-5uj1A:
undetectable		 3ax9B-5uj1A:
5.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DGQ_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE P)		 5uj1 DNA TOPOISOMERASE 1
(Mycobacterium
tuberculosis) 		4 / 5 TYR A 580
ILE A 203
TYR A 517
THR A 518
 None
 1.44A 3dgqA-5uj1A:
undetectable		 3dgqA-5uj1A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5uj1 DNA TOPOISOMERASE 1
(Mycobacterium
tuberculosis) 		5 / 10 ILE A 631
GLY A 624
PHE A 607
TYR A 174
VAL A 178
 None
 1.17A 3elzB-5uj1A:
undetectable		 3elzB-5uj1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 5uj1 DNA TOPOISOMERASE 1
(Mycobacterium
tuberculosis) 		5 / 10 LYS A  28
LEU A  32
SER A  34
ILE A 141
GLY A 338
 None
 1.03A 3ijxB-5uj1A:
undetectable
3ijxD-5uj1A:
undetectable		 3ijxB-5uj1A:
14.92
3ijxD-5uj1A:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB262_1
(GLUTAMATE RECEPTOR 2)		 5uj1 DNA TOPOISOMERASE 1
(Mycobacterium
tuberculosis) 		5 / 10 ILE A 141
GLY A 338
LYS A  28
LEU A  32
SER A  34
 None
 0.96A 3ik6B-5uj1A:
undetectable
3ik6E-5uj1A:
undetectable		 3ik6B-5uj1A:
14.92
3ik6E-5uj1A:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 5uj1 DNA TOPOISOMERASE 1
(Mycobacterium
tuberculosis) 		5 / 10 LYS A  28
LEU A  32
SER A  34
ILE A 141
GLY A 338
 None
 0.93A 3ik6B-5uj1A:
undetectable
3ik6E-5uj1A:
undetectable		 3ik6B-5uj1A:
14.92
3ik6E-5uj1A:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_B_HFZB800_1
(GLUTAMATE RECEPTOR 2)		 5uj1 DNA TOPOISOMERASE 1
(Mycobacterium
tuberculosis) 		5 / 10 LYS A  28
LEU A  32
SER A  34
ILE A 141
GLY A 338
 None
 0.93A 3iluB-5uj1A:
undetectable
3iluE-5uj1A:
undetectable		 3iluB-5uj1A:
14.92
3iluE-5uj1A:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_E_HFZE800_1
(GLUTAMATE RECEPTOR 2)		 5uj1 DNA TOPOISOMERASE 1
(Mycobacterium
tuberculosis) 		5 / 11 ILE A 141
GLY A 338
LYS A  28
LEU A  32
SER A  34
 None
 0.94A 3iluB-5uj1A:
undetectable
3iluE-5uj1A:
undetectable		 3iluB-5uj1A:
14.92
3iluE-5uj1A:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZ0_B_CLYB900_1
(LINCOSAMIDE
NUCLEOTIDYLTRANSFERA
SE)		 5uj1 DNA TOPOISOMERASE 1
(Mycobacterium
tuberculosis) 		4 / 8 GLU A 421
TYR A 471
PHE A 307
ILE A 340
 None
 1.05A 3jz0B-5uj1A:
undetectable		 3jz0B-5uj1A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5uj1 DNA TOPOISOMERASE 1
(Mycobacterium
tuberculosis) 		4 / 7 ARG A 318
SER A 310
ARG A 426
ILE A 392
 None
 0.92A 3ln1C-5uj1A:
undetectable		 3ln1C-5uj1A:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LW5_B_PQNB5002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5uj1 DNA TOPOISOMERASE 1
(Mycobacterium
tuberculosis) 		5 / 10 PHE A 322
SER A 323
ALA A 331
LEU A 419
ALA A 316
 None
 1.37A 3lw5B-5uj1A:
undetectable		 3lw5B-5uj1A:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_A_ACRA701_2
(ALPHA-GLUCOSIDASE)		 5uj1 DNA TOPOISOMERASE 1
(Mycobacterium
tuberculosis) 		4 / 5 PRO A  53
ILE A  84
TYR A 176
TRP A 183
 None
 1.45A 3phaA-5uj1A:
undetectable		 3phaA-5uj1A:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5uj1 DNA TOPOISOMERASE 1
(Mycobacterium
tuberculosis) 		5 / 12 GLU A 519
LEU A 312
GLU A 477
THR A 327
ILE A 330
 None
 1.00A 4hytA-5uj1A:
undetectable		 4hytA-5uj1A:
6.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_C_OBNC2004_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5uj1 DNA TOPOISOMERASE 1
(Mycobacterium
tuberculosis) 		5 / 12 GLU A 519
LEU A 312
GLU A 477
THR A 327
ILE A 330
 None
 0.99A 4hytC-5uj1A:
undetectable		 4hytC-5uj1A:
6.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K17_B_OHBB701_0
(LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 16A)		 5uj1 DNA TOPOISOMERASE 1
(Mycobacterium
tuberculosis) 		4 / 5 GLU A 207
SER A 560
ARG A 516
PRO A 690
 None
 1.24A 4k17B-5uj1A:
undetectable		 4k17B-5uj1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5uj1 DNA TOPOISOMERASE 1
(Mycobacterium
tuberculosis) 		4 / 5 LEU A 604
ASP A 171
GLU A 177
VAL A 619
 None
 1.29A 4nkvA-5uj1A:
undetectable		 4nkvA-5uj1A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA503_1
(PENTALENIC ACID
SYNTHASE)		 5uj1 DNA TOPOISOMERASE 1
(Mycobacterium
tuberculosis) 		4 / 7 LEU A 106
THR A 110
LEU A  96
LEU A  99
 None
 0.84A 4ubsA-5uj1A:
undetectable		 4ubsA-5uj1A:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5uj1 DNA TOPOISOMERASE 1
(Mycobacterium
tuberculosis) 		4 / 4 GLY A 338
LEU A 312
PHE A 307
ILE A 423
 None
 0.97A 4xv2A-5uj1A:
undetectable		 4xv2A-5uj1A:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5uj1 DNA TOPOISOMERASE 1
(Mycobacterium
tuberculosis) 		4 / 5 VAL A 133
TYR A 342
ILE A 340
THR A  27
 None
 1.33A 4ze1A-5uj1A:
undetectable		 4ze1A-5uj1A:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_A_ACTA401_0
(PROTON-GATED ION
CHANNEL)		 5uj1 DNA TOPOISOMERASE 1
(Mycobacterium
tuberculosis) 		4 / 6 ILE A 330
PHE A 322
ARG A 418
ILE A 414
 None
 1.23A 4zzcA-5uj1A:
undetectable
4zzcB-5uj1A:
undetectable		 4zzcA-5uj1A:
undetectable
4zzcB-5uj1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_B_ACTB401_0
(PROTON-GATED ION
CHANNEL)		 5uj1 DNA TOPOISOMERASE 1
(Mycobacterium
tuberculosis) 		4 / 6 ILE A 330
PHE A 322
ARG A 418
ILE A 414
 None
 1.19A 4zzcB-5uj1A:
undetectable
4zzcC-5uj1A:
undetectable		 4zzcB-5uj1A:
undetectable
4zzcC-5uj1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5uj1 DNA TOPOISOMERASE 1
(Mycobacterium
tuberculosis) 		4 / 7 ARG A 201
ARG A 206
ASP A 209
TYR A 580
 None
 1.32A 5a06A-5uj1A:
undetectable		 5a06A-5uj1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_C_SORC1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5uj1 DNA TOPOISOMERASE 1
(Mycobacterium
tuberculosis) 		4 / 7 ARG A 201
ARG A 206
ASP A 209
TYR A 580
 None
 1.33A 5a06C-5uj1A:
2.3		 5a06C-5uj1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5uj1 DNA TOPOISOMERASE 1
(Mycobacterium
tuberculosis) 		4 / 7 ARG A 201
ARG A 206
ASP A 209
TYR A 580
 None
 1.34A 5a06D-5uj1A:
2.3		 5a06D-5uj1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_E_SORE1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5uj1 DNA TOPOISOMERASE 1
(Mycobacterium
tuberculosis) 		4 / 7 ARG A 201
ARG A 206
ASP A 209
TYR A 580
 None
 1.32A 5a06E-5uj1A:
undetectable		 5a06E-5uj1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5uj1 DNA TOPOISOMERASE 1
(Mycobacterium
tuberculosis) 		4 / 7 ARG A 201
ARG A 206
ASP A 209
TYR A 580
 None
 1.33A 5a06F-5uj1A:
undetectable		 5a06F-5uj1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_E_PFLE406_1
(PROTON-GATED ION
CHANNEL)		 5uj1 DNA TOPOISOMERASE 1
(Mycobacterium
tuberculosis) 		5 / 10 TYR A 537
ILE A 540
ILE A 541
ILE A 202
ILE A 203
 None
 1.09A 5murE-5uj1A:
undetectable		 5murE-5uj1A:
28.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5uj1 DNA TOPOISOMERASE 1
(Mycobacterium
tuberculosis) 		4 / 4 SER A 353
ALA A 354
GLN A 361
THR A 427
 None
 1.22A 5n0rA-5uj1A:
2.9		 5n0rA-5uj1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5uj1 DNA TOPOISOMERASE 1
(Mycobacterium
tuberculosis) 		4 / 4 SER A 353
ALA A 354
GLN A 361
THR A 427
 None
 1.23A 5n0sA-5uj1A:
2.9		 5n0sA-5uj1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5uj1 DNA TOPOISOMERASE 1
(Mycobacterium
tuberculosis) 		4 / 5 SER A 353
ALA A 354
GLN A 361
THR A 427
 None
 1.23A 5n0tA-5uj1A:
3.0		 5n0tA-5uj1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5uj1 DNA TOPOISOMERASE 1
(Mycobacterium
tuberculosis) 		4 / 4 SER A 353
ALA A 354
GLN A 361
THR A 427
 None
 1.24A 5n0wA-5uj1A:
2.9		 5n0wA-5uj1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5uj1 DNA TOPOISOMERASE 1
(Mycobacterium
tuberculosis) 		4 / 5 SER A 353
ALA A 354
GLN A 361
THR A 427
 None
 1.26A 5n0wB-5uj1A:
3.1		 5n0wB-5uj1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5uj1 DNA TOPOISOMERASE 1
(Mycobacterium
tuberculosis) 		4 / 4 SER A 353
ALA A 354
GLN A 361
THR A 427
 None
 1.22A 5n0xA-5uj1A:
2.9		 5n0xA-5uj1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5uj1 DNA TOPOISOMERASE 1
(Mycobacterium
tuberculosis) 		4 / 5 SER A 353
ALA A 354
GLN A 361
THR A 427
 None
 1.24A 5n4iA-5uj1A:
2.8		 5n4iA-5uj1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 5uj1 DNA TOPOISOMERASE 1
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 526
ILE A 531
GLY A 530
LEU A 522
SER A 521
 None
 0.92A 5twjA-5uj1A:
undetectable		 5twjA-5uj1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_B_SAMB201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 5uj1 DNA TOPOISOMERASE 1
(Mycobacterium
tuberculosis) 		5 / 10 LEU A 526
ILE A 531
GLY A 530
LEU A 522
SER A 521
 None
 0.98A 5twjB-5uj1A:
undetectable		 5twjB-5uj1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_C_SAMC201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 5uj1 DNA TOPOISOMERASE 1
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 526
ILE A 531
GLY A 530
LEU A 522
SER A 521
 None
 0.94A 5twjC-5uj1A:
undetectable		 5twjC-5uj1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_B_SAMB301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 5uj1 DNA TOPOISOMERASE 1
(Mycobacterium
tuberculosis) 		5 / 12 TYR A 537
GLN A 314
ILE A 202
LEU A 529
GLY A 530
 None
 1.01A 5wyqB-5uj1A:
undetectable		 5wyqB-5uj1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_B_H4BB501_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5uj1 DNA TOPOISOMERASE 1
(Mycobacterium
tuberculosis) 		4 / 7 SER A  45
VAL A  23
ARG A  30
GLU A  24
 None
 1.45A 6av6A-5uj1A:
0.0
6av6B-5uj1A:
undetectable		 6av6A-5uj1A:
19.05
6av6B-5uj1A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5uj1 DNA TOPOISOMERASE 1
(Mycobacterium
tuberculosis) 		4 / 7 GLU A  24
SER A  45
VAL A  23
ARG A  30
 None
 1.30A 6av6C-5uj1A:
undetectable
6av6D-5uj1A:
undetectable		 6av6C-5uj1A:
19.05
6av6D-5uj1A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NCS_A_ACTA303_0
(N-ACETYLNEURAMINIC
ACID (SIALIC ACID)
SYNTHETASE)		 5uj1 DNA TOPOISOMERASE 1
(Mycobacterium
tuberculosis) 		3 / 3 ILE A 169
THR A 166
PRO A  81
 None
 0.57A 6ncsA-5uj1A:
undetectable		 6ncsA-5uj1A:
undetectable