SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5uj8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_A_CHDA1150_0
(ALCOHOL
DEHYDROGENASE)		 5uj8 ORIGIN RECOGNITION
COMPLEX SUBUNIT 3
(Homo
sapiens) 		5 / 11 LEU A 230
MET A 222
LEU A 248
VAL A 267
ILE A 273
 None
 1.27A 1ee2A-5uj8A:
undetectable		 1ee2A-5uj8A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_1
(ALCOHOL
DEHYDROGENASE)		 5uj8 ORIGIN RECOGNITION
COMPLEX SUBUNIT 3
(Homo
sapiens) 		5 / 11 LEU A 230
MET A 222
LEU A 248
VAL A 267
ILE A 273
 None
 1.32A 1ee2B-5uj8A:
undetectable		 1ee2B-5uj8A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_H_ACTH3006_0
(BETA-CARBONIC
ANHYDRASE)		 5uj8 ORIGIN RECOGNITION
COMPLEX SUBUNIT 3
(Homo
sapiens) 		4 / 6 GLN A 322
ASP A 113
VAL A 109
CYH A 281
 None
 1.47A 1ekjG-5uj8A:
undetectable
1ekjH-5uj8A:
undetectable		 1ekjG-5uj8A:
14.63
1ekjH-5uj8A:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_1_T441128_1
(TRANSTHYRETIN)		 5uj8 ORIGIN RECOGNITION
COMPLEX SUBUNIT 3
(Homo
sapiens) 		4 / 5 LEU A 219
GLU A 223
ALA A 138
LEU A 136
 None
 1.17A 1eta1-5uj8A:
undetectable		 1eta1-5uj8A:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_B_ADNB1502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5uj8 ORIGIN RECOGNITION
COMPLEX SUBUNIT 3
(Homo
sapiens) 		5 / 12 LEU A 688
HIS A 637
THR A 708
LEU A 638
HIS A 601
 None
 1.41A 1v8bB-5uj8A:
undetectable		 1v8bB-5uj8A:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1216_1
(LIPOPROTEIN LPPX)		 5uj8 ORIGIN RECOGNITION
COMPLEX SUBUNIT 3
(Homo
sapiens) 		4 / 5 ILE A 152
LEU A 200
SER A 201
ARG A 204
 None
 0.91A 2byoA-5uj8A:
undetectable		 2byoA-5uj8A:
13.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1217_1
(LIPOPROTEIN LPPX)		 5uj8 ORIGIN RECOGNITION
COMPLEX SUBUNIT 3
(Homo
sapiens) 		4 / 4 VAL A 376
LEU A 358
ILE A 355
LEU A 402
 None
 1.05A 2byoA-5uj8A:
undetectable		 2byoA-5uj8A:
13.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNJ_A_225A501_1
(CYTOCHROME P450 2C8)		 5uj8 ORIGIN RECOGNITION
COMPLEX SUBUNIT 2
(Homo
sapiens) 		5 / 10 ILE E 408
LEU E 390
VAL E 351
THR E 356
ILE E 418
 None
 1.01A 2nnjA-5uj8E:
undetectable		 2nnjA-5uj8E:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGZ_D_COCD401_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5uj8 ORIGIN RECOGNITION
COMPLEX SUBUNIT 2
(Homo
sapiens) 		4 / 6 TYR E 294
TRP E 301
TYR E 314
ILE E 311
 None
 1.42A 2pgzD-5uj8E:
undetectable
2pgzE-5uj8E:
undetectable		 2pgzD-5uj8E:
21.08
2pgzE-5uj8E:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)		 5uj8 ORIGIN RECOGNITION
COMPLEX SUBUNIT 3
(Homo
sapiens) 		4 / 7 LEU A  69
ASN A  68
GLU A  64
LEU A  61
 None
 1.15A 2w8yA-5uj8A:
undetectable		 2w8yA-5uj8A:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)		 5uj8 ORIGIN RECOGNITION
COMPLEX SUBUNIT 3
(Homo
sapiens) 		3 / 3 HIS A 586
GLU A 590
HIS A 591
 None
 0.80A 3ba0A-5uj8A:
undetectable		 3ba0A-5uj8A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A201_2
(POL POLYPROTEIN)		 5uj8 ORIGIN RECOGNITION
COMPLEX SUBUNIT 3
(Homo
sapiens) 		5 / 9 ALA A 103
ILE A 218
GLY A 251
ILE A 252
LEU A  69
 None
 1.25A 3u7sB-5uj8A:
undetectable		 3u7sB-5uj8A:
7.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5uj8 ORIGIN RECOGNITION
COMPLEX SUBUNIT 3
(Homo
sapiens) 		5 / 12 ILE A 682
VAL A 704
LEU A 643
SER A 641
ALA A 652
 None
 1.18A 3w67C-5uj8A:
undetectable		 3w67C-5uj8A:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_A_TYLA1188_1
(BROMODOMAIN
CONTAINING 2)		 5uj8 ORIGIN RECOGNITION
COMPLEX SUBUNIT 3
(Homo
sapiens) 		4 / 5 VAL A 288
LEU A 292
LEU A 293
ILE A 325
 None
 0.97A 4a9jA-5uj8A:
undetectable		 4a9jA-5uj8A:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQ7_A_LEUA902_0
(LEUCINE--TRNA LIGASE)		 5uj8 ORIGIN RECOGNITION
COMPLEX SUBUNIT 3
(Homo
sapiens) 		4 / 7 MET A 199
LEU A 200
ASP A 196
HIS A 240
 None
 1.31A 4aq7A-5uj8A:
2.2		 4aq7A-5uj8A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5uj8 ORIGIN RECOGNITION
COMPLEX SUBUNIT 3
(Homo
sapiens) 		4 / 6 TYR A 429
PRO A 430
LEU A 438
GLU A 437
 None
 1.15A 4z4cA-5uj8A:
undetectable		 4z4cA-5uj8A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 5uj8 ORIGIN RECOGNITION
COMPLEX SUBUNIT 2
(Homo
sapiens) 		3 / 3 GLU E 387
HIS E 306
ASP E 333
 None
 0.82A 5c0oG-5uj8E:
undetectable		 5c0oG-5uj8E:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5uj8 ORIGIN RECOGNITION
COMPLEX SUBUNIT 2
(Homo
sapiens) 		4 / 6 SER E 423
ALA E 422
HIS E 393
LEU E 391
 None
 1.18A 5dzkB-5uj8E:
undetectable
5dzkP-5uj8E:
undetectable		 5dzkB-5uj8E:
21.17
5dzkP-5uj8E:
4.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_A_ACTA803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 5uj8 ORIGIN RECOGNITION
COMPLEX SUBUNIT 3
(Homo
sapiens) 		4 / 4 GLU A  99
PRO A 101
ILE A 100
LEU A 270
 None
 1.08A 5m45A-5uj8A:
undetectable		 5m45A-5uj8A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_D_ACTD803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 5uj8 ORIGIN RECOGNITION
COMPLEX SUBUNIT 3
(Homo
sapiens) 		4 / 4 GLU A  99
PRO A 101
ILE A 100
LEU A 270
 None
 1.17A 5m45D-5uj8A:
undetectable		 5m45D-5uj8A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_G_ACTG803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 5uj8 ORIGIN RECOGNITION
COMPLEX SUBUNIT 3
(Homo
sapiens) 		4 / 4 GLU A  99
PRO A 101
ILE A 100
LEU A 270
 None
 1.08A 5m45G-5uj8A:
undetectable		 5m45G-5uj8A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_J_ACTJ803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 5uj8 ORIGIN RECOGNITION
COMPLEX SUBUNIT 3
(Homo
sapiens) 		4 / 4 GLU A  99
PRO A 101
ILE A 100
LEU A 270
 None
 1.15A 5m45J-5uj8A:
0.0		 5m45J-5uj8A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5uj8 ORIGIN RECOGNITION
COMPLEX SUBUNIT 3
(Homo
sapiens) 		5 / 12 LEU A 688
HIS A 637
THR A 708
LEU A 638
HIS A 601
 None
 1.42A 5m66A-5uj8A:
undetectable		 5m66A-5uj8A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_A_NIZA810_1
(CATALASE-PEROXIDASE)		 5uj8 ORIGIN RECOGNITION
COMPLEX SUBUNIT 2
(Homo
sapiens) 		4 / 6 ARG E 320
HIS E 393
LEU E 313
SER E 452
 None
 1.46A 5syjA-5uj8E:
undetectable		 5syjA-5uj8E:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_B_NIZB810_1
(CATALASE-PEROXIDASE)		 5uj8 ORIGIN RECOGNITION
COMPLEX SUBUNIT 2
(Homo
sapiens) 		4 / 6 ARG E 320
HIS E 393
LEU E 313
SER E 452
 None
 1.47A 5syjB-5uj8E:
undetectable		 5syjB-5uj8E:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW5_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 5uj8 ORIGIN RECOGNITION
COMPLEX SUBUNIT 3
(Homo
sapiens) 		4 / 8 SER A  80
CYH A 272
GLU A 274
ALA A 103
 None
 0.74A 5vw5A-5uj8A:
undetectable		 5vw5A-5uj8A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_B_CHDB401_0
(BILE SALT HYDROLASE)		 5uj8 ORIGIN RECOGNITION
COMPLEX SUBUNIT 2
(Homo
sapiens) 		5 / 10 LEU E 323
LEU E 297
PHE E 298
LEU E 444
LEU E 305
 None
 1.07A 5y7pB-5uj8E:
undetectable		 5y7pB-5uj8E:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_D_CHDD401_0
(BILE SALT HYDROLASE)		 5uj8 ORIGIN RECOGNITION
COMPLEX SUBUNIT 2
(Homo
sapiens) 		5 / 10 LEU E 323
LEU E 297
PHE E 298
LEU E 444
LEU E 305
 None
 1.03A 5y7pD-5uj8E:
undetectable		 5y7pD-5uj8E:
22.42