SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ujm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_D_CCSD47_0
(GLUTATHIONE
S-TRANSFERASE)		 5ujm ORIGIN RECOGNITION
COMPLEX SUBUNIT 5
(Homo
sapiens) 		4 / 7 THR E  39
GLY E  37
LEU E 157
LYS E 126
 ATP  E 501 (-3.9A)
None
None
ATP  E 501 ( 3.7A)
 0.87A 1gtiD-5ujmE:
undetectable		 1gtiD-5ujmE:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_C_THAC3_1
(LIVER
CARBOXYLESTERASE I)		 5ujm ORIGIN RECOGNITION
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 LEU A 573
VAL A 649
LEU A 617
LEU A 625
LEU A 636
 None
 1.21A 1mx1C-5ujmA:
2.4		 1mx1C-5ujmA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE2_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 5ujm ORIGIN RECOGNITION
COMPLEX SUBUNIT 5
(Homo
sapiens) 		3 / 3 GLU E  24
HIS E  26
HIS E  27
 None
 0.72A 1oe2A-5ujmE:
undetectable		 1oe2A-5ujmE:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_C_SPMC1434_1
(NITROALKANE OXIDASE)		 5ujm ORIGIN RECOGNITION
COMPLEX SUBUNIT 5
(Homo
sapiens) 		5 / 12 LEU E 187
ALA E 229
LEU E 228
LEU E 212
VAL E 214
 None
 1.05A 2c12C-5ujmE:
undetectable		 2c12C-5ujmE:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLJ_A_SPMA1303_1
(POTASSIUM CHANNEL)		 5ujm ORIGIN RECOGNITION
COMPLEX SUBUNIT 1
(Homo
sapiens) 		3 / 3 ARG A 720
ARG A 721
PRO A 536
 ATP  A 901 (-3.9A)
None
ATP  A 901 (-4.0A)
 1.00A 2wljA-5ujmA:
undetectable		 2wljA-5ujmA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_A_J01A500_1
(ORF12)		 5ujm ORIGIN RECOGNITION
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 10 ILE A 767
LEU A 805
LEU A 858
ARG A 779
ALA A 780
 None
 1.27A 2xf3A-5ujmA:
undetectable		 2xf3A-5ujmA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_A_J01A500_1
(ORF12)		 5ujm ORIGIN RECOGNITION
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 10 VAL A 746
ILE A 705
LEU A 723
LEU A 694
ALA A 499
 None
 0.84A 2xf3A-5ujmA:
undetectable		 2xf3A-5ujmA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLO_A_TESA1920_1
(ANDROGEN RECEPTOR)		 5ujm ORIGIN RECOGNITION
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 LEU A 826
LEU A 778
VAL A 772
THR A 819
PHE A 795
 None
 1.35A 2yloA-5ujmA:
undetectable		 2yloA-5ujmA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_2
(CYTOCHROME P450 2R1)		 5ujm ORIGIN RECOGNITION
COMPLEX SUBUNIT 1
(Homo
sapiens) 		3 / 3 MET A 758
VAL A 712
GLU A 753
 None
 0.69A 3c6gA-5ujmA:
undetectable		 3c6gA-5ujmA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FBX_A_ACTA608_0
(PUTATIVE
PHOSPHOLIPASE B-LIKE
2)		 5ujm ORIGIN RECOGNITION
COMPLEX SUBUNIT 1
(Homo
sapiens) 		3 / 3 GLU A 546
VAL A 547
CYH A 550
 None
 0.97A 3fbxA-5ujmA:
undetectable		 3fbxA-5ujmA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5ujm ORIGIN RECOGNITION
COMPLEX SUBUNIT 5
(Homo
sapiens) 		4 / 7 TYR E 199
VAL E 214
ILE E 208
ARG E 255
 None
 1.05A 3mssB-5ujmE:
undetectable		 3mssB-5ujmE:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_A_URFA400_1
(URIDINE
PHOSPHORYLASE 1)		 5ujm ORIGIN RECOGNITION
COMPLEX SUBUNIT 5
(Homo
sapiens) 		5 / 9 GLY E 213
GLU E 258
LEU E 211
LEU E 212
ILE E 208
 None
 1.37A 3nbqA-5ujmE:
undetectable		 3nbqA-5ujmE:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_1
(DIHYDROPTEROATE
SYNTHASE DHPS)		 5ujm ORIGIN RECOGNITION
COMPLEX SUBUNIT 1
ORIGIN RECOGNITION
COMPLEX SUBUNIT 5
(Homo
sapiens;
Homo
sapiens) 		3 / 3 LYS E 164
ASN E 168
ASP A 840
 None
 0.62A 4o1eA-5ujmE:
undetectable		 4o1eA-5ujmE:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_A_FK5A205_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 5ujm ORIGIN RECOGNITION
COMPLEX SUBUNIT 5
(Homo
sapiens) 		5 / 10 LEU E 144
LEU E 130
LEU E  72
ILE E  76
LEU E  73
 None
 0.99A 4odoA-5ujmE:
undetectable		 4odoA-5ujmE:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 5ujm ORIGIN RECOGNITION
COMPLEX SUBUNIT 5
(Homo
sapiens) 		5 / 10 LEU E 144
LEU E 130
LEU E  72
ILE E  76
LEU E  73
 None
 1.05A 4odoB-5ujmE:
undetectable		 4odoB-5ujmE:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_C_FK5C204_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 5ujm ORIGIN RECOGNITION
COMPLEX SUBUNIT 5
(Homo
sapiens) 		5 / 10 LEU E 144
LEU E 130
LEU E  72
ILE E  76
LEU E  73
 None
 1.08A 4odoC-5ujmE:
undetectable		 4odoC-5ujmE:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 5ujm ORIGIN RECOGNITION
COMPLEX SUBUNIT 5
(Homo
sapiens) 		5 / 12 LEU E 144
LEU E 130
LEU E  72
ILE E  76
LEU E  73
 None
 1.00A 4odrA-5ujmE:
undetectable
4odrB-5ujmE:
undetectable		 4odrA-5ujmE:
13.97
4odrB-5ujmE:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 5ujm ORIGIN RECOGNITION
COMPLEX SUBUNIT 5
(Homo
sapiens) 		5 / 11 LEU E 144
LEU E 130
LEU E  72
ILE E  76
LEU E  73
 None
 1.05A 4odrA-5ujmE:
undetectable
4odrB-5ujmE:
undetectable		 4odrA-5ujmE:
13.97
4odrB-5ujmE:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 5ujm ORIGIN RECOGNITION
COMPLEX SUBUNIT 5
(Homo
sapiens) 		5 / 12 LEU E 124
PHE E 156
ILE E  35
ARG E  11
ALA E 127
 None
 0.94A 5h5fA-5ujmE:
undetectable		 5h5fA-5ujmE:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 5ujm ORIGIN RECOGNITION
COMPLEX SUBUNIT 5
(Homo
sapiens) 		5 / 12 LEU E 124
PHE E 156
ILE E  35
GLY E  37
ALA E 127
 None
 1.08A 5h5fA-5ujmE:
undetectable		 5h5fA-5ujmE:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_B_ACTB713_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 5ujm ORIGIN RECOGNITION
COMPLEX SUBUNIT 1
(Homo
sapiens) 		3 / 3 GLY A 534
GLN A 679
LYS A 540
 None
None
ATP  A 901 (-3.0A)
 0.88A 5imsB-5ujmA:
undetectable		 5imsB-5ujmA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM9_B_ADNB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 5ujm ORIGIN RECOGNITION
COMPLEX SUBUNIT 5
(Homo
sapiens) 		5 / 12 ILE E 311
PHE E 308
ILE E 369
LEU E 315
VAL E 423
 None
 1.26A 5km9B-5ujmE:
undetectable		 5km9B-5ujmE:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_B_SAMB1304_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 5ujm ORIGIN RECOGNITION
COMPLEX SUBUNIT 1
(Homo
sapiens) 		3 / 3 ASN A 848
TYR A 763
CYH A 829
 None
 0.96A 5lsuB-5ujmA:
undetectable		 5lsuB-5ujmA:
18.63