SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5uk5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB8_0
(GRAMICIDIN A)		 5uk5 NEUROGENIC LOCUS
NOTCH HOMOLOG
PROTEIN 1
(Rattus
norvegicus) 		3 / 3 VAL A 324
VAL A 322
TRP A 327
 FUC  A 604 ( 4.9A)
FUC  A 604 (-4.4A)
None
 0.70A 1bdwA-5uk5A:
undetectable
1bdwB-5uk5A:
undetectable		 1bdwA-5uk5A:
3.47
1bdwB-5uk5A:
3.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5uk5 NEUROGENIC LOCUS
NOTCH HOMOLOG
PROTEIN 1
(Rattus
norvegicus) 		3 / 3 GLY A 364
ASP A 374
ASP A 388
 None
 0.44A 3ou7C-5uk5A:
undetectable		 3ou7C-5uk5A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3O_A_DLUA399_1
(PFV INTEGRASE)		 5uk5 NEUROGENIC LOCUS
NOTCH HOMOLOG
PROTEIN 1
(Rattus
norvegicus) 		4 / 7 ASP A 469
ASP A 452
GLN A 442
GLU A 455
 CA  A 603 (-2.9A)
CA  A 603 (-2.5A)
None
CA  A 603 ( 2.5A)
 1.29A 3s3oA-5uk5A:
undetectable		 3s3oA-5uk5A:
16.80