SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5uke'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O7O_A_DXTA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 5uke INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 3
(Homo
sapiens) 		5 / 12 SER A  17
ASN A 109
PRO A 116
THR A  20
ILE A  88
 None
 1.36A 2o7oA-5ukeA:
undetectable		 2o7oA-5ukeA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_1
(REPRESSOR PROTEIN
MPHR(A))		 5uke INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 3
(Homo
sapiens) 		4 / 5 ASN A   9
ARG A  75
HIS A  19
ALA A  12
 None
 0.99A 3frqA-5ukeA:
undetectable		 3frqA-5ukeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_1
(REPRESSOR PROTEIN
MPHR(A))		 5uke INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 3
(Homo
sapiens) 		4 / 7 ASN A   9
ARG A  75
HIS A  19
ALA A  12
 None
 0.97A 3frqB-5ukeA:
undetectable		 3frqB-5ukeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_A_08JA602_1
(CYTOCHROME P450 3A4)		 5uke INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 3
(Homo
sapiens) 		4 / 7 LEU A  22
THR A  87
ILE A  88
LEU A  25
 None
 1.02A 5te8A-5ukeA:
undetectable		 5te8A-5ukeA:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_E_AM2E301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5uke INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 3
(Homo
sapiens) 		4 / 7 HIS A 100
ARG A  13
HIS A  19
GLU A  32
 None
 1.26A 6mn4E-5ukeA:
undetectable		 6mn4E-5ukeA:
undetectable