SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ukg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CTR_A_TFPA153_1
(CALMODULIN)		 5ukg K-GECO
(Entacmaea
quadricolor) 		5 / 9 ILE A 365
LEU A 370
MET A 389
ALA A 393
VAL A 401
 None
 0.89A 1ctrA-5ukgA:
12.0		 1ctrA-5ukgA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CTR_A_TFPA153_1
(CALMODULIN)		 5ukg K-GECO
(Entacmaea
quadricolor) 		5 / 9 ILE A 365
LEU A 370
MET A 389
GLU A 388
VAL A 401
 None
 1.21A 1ctrA-5ukgA:
12.0		 1ctrA-5ukgA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		 5ukg K-GECO
(Entacmaea
quadricolor) 		7 / 11 ILE A 292
LEU A 297
MET A 301
LEU A 304
MET A 316
VAL A 320
LEU A  15
 None
 1.17A 1dtlA-5ukgA:
12.8		 1dtlA-5ukgA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		 5ukg K-GECO
(Entacmaea
quadricolor) 		7 / 11 LEU A 297
MET A 301
LEU A 304
MET A 316
VAL A 320
MET A 336
LEU A  15
 None
 1.41A 1dtlA-5ukgA:
12.8		 1dtlA-5ukgA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		 5ukg K-GECO
(Entacmaea
quadricolor) 		7 / 11 PHE A 284
ILE A 292
LEU A 297
MET A 301
LEU A 304
MET A 316
VAL A 320
 None
 0.76A 1dtlA-5ukgA:
12.8		 1dtlA-5ukgA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		 5ukg K-GECO
(Entacmaea
quadricolor) 		7 / 11 PHE A 284
LEU A 297
MET A 301
LEU A 304
MET A 316
VAL A 320
MET A 336
 None
 0.92A 1dtlA-5ukgA:
12.8		 1dtlA-5ukgA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		 5ukg K-GECO
(Entacmaea
quadricolor) 		4 / 8 MET A 301
GLN A 306
PRO A 308
GLU A 312
 None
 0.70A 1dtlA-5ukgA:
12.8		 1dtlA-5ukgA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		 5ukg K-GECO
(Entacmaea
quadricolor) 		4 / 8 MET A 301
PRO A 308
GLU A 312
GLU A 352
 None
 0.94A 1dtlA-5ukgA:
12.8		 1dtlA-5ukgA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_A_VIBA502_1
(THIAMIN
PYROPHOSPHOKINASE)		 5ukg K-GECO
(Entacmaea
quadricolor) 		4 / 8 LEU A  63
SER A 265
ASN A  32
GLN A 273
 None
None
NRQ  A 186 ( 3.6A)
None
 1.14A 1ig3A-5ukgA:
undetectable
1ig3B-5ukgA:
undetectable		 1ig3A-5ukgA:
20.44
1ig3B-5ukgA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_B_VIBB501_1
(THIAMIN
PYROPHOSPHOKINASE)		 5ukg K-GECO
(Entacmaea
quadricolor) 		4 / 7 GLN A 273
LEU A  63
SER A 265
ASN A  32
 None
None
None
NRQ  A 186 ( 3.6A)
 1.25A 1ig3A-5ukgA:
undetectable
1ig3B-5ukgA:
undetectable		 1ig3A-5ukgA:
20.44
1ig3B-5ukgA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA155_1
(CALMODULIN)		 5ukg K-GECO
(Entacmaea
quadricolor) 		4 / 7 GLU A 349
PHE A 284
MET A 336
ALA A 338
 None
 1.34A 1linA-5ukgA:
16.5		 1linA-5ukgA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5ukg K-GECO
(Entacmaea
quadricolor) 		6 / 12 PHE A 284
ILE A 292
LEU A 297
MET A 301
MET A 316
ILE A 317
 None
 1.05A 1lxfC-5ukgA:
9.7		 1lxfC-5ukgA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 5ukg K-GECO
(Entacmaea
quadricolor) 		3 / 3 TYR A 110
GLU A 276
THR A 270
 None
 0.90A 2y7hB-5ukgA:
undetectable		 2y7hB-5ukgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		 5ukg K-GECO
(Entacmaea
quadricolor) 		5 / 12 GLN A 256
GLY A 261
VAL A  54
ASP A 178
ALA A 176
 None
 1.14A 3d91B-5ukgA:
undetectable		 3d91B-5ukgA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M93_B_ACTB303_0
(S25-26 FAB (IGG1K)
HEAVY CHAIN
S25-26 FAB (IGG1K)
LIGHT CHAIN)		 5ukg K-GECO
(Entacmaea
quadricolor) 		4 / 5 GLY A 159
ALA A 106
PHE A 191
GLU A 104
 None
None
None
NRQ  A 186 ( 3.6A)
 0.97A 4m93B-5ukgA:
undetectable
4m93C-5ukgA:
undetectable		 4m93B-5ukgA:
undetectable
4m93C-5ukgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_A_TFPA203_1
(CALMODULIN)		 5ukg K-GECO
(Entacmaea
quadricolor) 		5 / 8 ILE A 365
LEU A 370
MET A 389
ALA A 393
VAL A 401
 None
 0.69A 4rjdA-5ukgA:
11.7		 4rjdA-5ukgA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_A_TFPA203_1
(CALMODULIN)		 5ukg K-GECO
(Entacmaea
quadricolor) 		4 / 8 PHE A 284
ILE A 292
LEU A 297
MET A 301
 None
 0.63A 4rjdA-5ukgA:
11.7		 4rjdA-5ukgA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_A_TFPA203_1
(CALMODULIN)		 5ukg K-GECO
(Entacmaea
quadricolor) 		4 / 8 PHE A 284
ILE A 292
LEU A 297
MET A 316
 None
 0.51A 4rjdA-5ukgA:
11.7		 4rjdA-5ukgA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_A_TFPA203_1
(CALMODULIN)		 5ukg K-GECO
(Entacmaea
quadricolor) 		5 / 8 PHE A 357
ILE A 365
LEU A 370
ALA A 393
VAL A 401
 None
 0.66A 4rjdA-5ukgA:
11.7		 4rjdA-5ukgA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_B_TFPB203_1
(CALMODULIN)		 5ukg K-GECO
(Entacmaea
quadricolor) 		4 / 7 LEU A 370
MET A 389
ALA A 393
MET A 410
 None
 1.00A 4rjdB-5ukgA:
11.9		 4rjdB-5ukgA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_B_TFPB203_1
(CALMODULIN)		 5ukg K-GECO
(Entacmaea
quadricolor) 		5 / 7 PHE A 284
LEU A 297
MET A 301
MET A 336
MET A 337
 None
 1.01A 4rjdB-5ukgA:
11.9		 4rjdB-5ukgA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_B_TFPB203_1
(CALMODULIN)		 5ukg K-GECO
(Entacmaea
quadricolor) 		4 / 7 PHE A 357
LEU A 370
ALA A 393
MET A 410
 None
 1.01A 4rjdB-5ukgA:
11.9		 4rjdB-5ukgA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZP0_A_DXCA500_0
(MULTIDRUG
TRANSPORTER MDFA)		 5ukg K-GECO
(Entacmaea
quadricolor) 		5 / 10 MET A 374
LEU A  20
LEU A 381
GLY A  26
MET A  19
 None
 1.36A 4zp0A-5ukgA:
undetectable		 4zp0A-5ukgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 5ukg K-GECO
(Entacmaea
quadricolor) 		4 / 7 THR A 230
LEU A  43
VAL A  84
GLU A  64
 None
 1.02A 5tudA-5ukgA:
undetectable		 5tudA-5ukgA:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 5ukg K-GECO
(Entacmaea
quadricolor) 		4 / 7 TYR A  82
ALA A 106
GLY A 159
TYR A 157
 None
 0.94A 5uxdA-5ukgA:
undetectable		 5uxdA-5ukgA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA503_1
(CYTOCHROME P450 2C9)		 5ukg K-GECO
(Entacmaea
quadricolor) 		4 / 6 PHE A 248
PRO A 249
GLY A 252
ASN A 251
 None
 0.95A 5x24A-5ukgA:
undetectable		 5x24A-5ukgA:
14.20