SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ukp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JG4_A_SAMA500_1 (PROTEIN-L-ISOASPARTA TE O-METHYLTRANSFERASE)	5ukp	DH522.1 FAB FRAGMENT HEAVY CHAIN (Macaca mulatta)	4 / 8	GLY H 55 SER H 70 ILE H 29 ASP H 32	None	0.89A	1jg4A-5ukpH: undetectable	1jg4A-5ukpH: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1N2X_B_SAMB402_0 (S-ADENOSYL-METHYLTRA NSFERASE MRAW)	5ukp	DH522.1 FAB FRAGMENT HEAVY CHAIN (Macaca mulatta)	5 / 12	GLY H 52 GLY H 55 GLY H 56 ASP H 31 GLY H 95	None	0.80A	1n2xB-5ukpH: undetectable	1n2xB-5ukpH: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Y03_A_5FWA601_1 (BETA-1 ADRENERGIC RECEPTOR)	5ukp	DH522.1 FAB FRAGMENT HEAVY CHAIN (Macaca mulatta)	5 / 12	VAL H 163 VAL H 182 SER H 180 ASN H 197 ASN H 155	None	1.45A	2y03A-5ukpH: undetectable	2y03A-5ukpH: 13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Y03_B_5FWB601_1 (BETA-1 ADRENERGIC RECEPTOR)	5ukp	DH522.1 FAB FRAGMENT HEAVY CHAIN (Macaca mulatta)	5 / 12	VAL H 163 VAL H 182 SER H 180 ASN H 197 ASN H 155	None	1.49A	2y03B-5ukpH: undetectable	2y03B-5ukpH: 13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4LDO_A_ALEA1402_1 (LYSOZYME, BETA-2 ADRENERGIC RECEPTOR)	5ukp	DH522.1 FAB FRAGMENT HEAVY CHAIN (Macaca mulatta)	5 / 10	VAL H 163 VAL H 182 SER H 180 ASN H 197 ASN H 155	None	1.48A	4ldoA-5ukpH: undetectable	4ldoA-5ukpH: 12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MMD_A_29EA603_1 (TRANSPORTER)	5ukp	DH522.1 FAB FRAGMENT HEAVY CHAIN (Macaca mulatta)	5 / 10	ASP H 32 TYR H 97 GLY H 52 SER H 96 GLY H 95	None	1.07A	4mmdA-5ukpH: undetectable	4mmdA-5ukpH: 11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MMD_B_29EB603_1 (TRANSPORTER)	5ukp	DH522.1 FAB FRAGMENT HEAVY CHAIN (Macaca mulatta)	5 / 12	ASP H 32 TYR H 97 GLY H 52 SER H 96 GLY H 95	None	1.08A	4mmdB-5ukpH: undetectable	4mmdB-5ukpH: 11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H7M_B_68HB405_0 (BETA-1 ADRENERGIC RECEPTOR)	5ukp	DH522.1 FAB FRAGMENT HEAVY CHAIN (Macaca mulatta)	5 / 12	VAL H 163 VAL H 182 SER H 180 ASN H 197 ASN H 155	None	1.44A	6h7mB-5ukpH: undetectable	6h7mB-5ukpH: 22.92

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1JG4_A_SAMA500_1","PROTEIN-L-ISOASPARTATE O-METHYLTRANSFERASE","5ukp","DH522.1 FAB FRAGMENT HEAVY CHAIN","Macaca mulatta",4,"GLY H  55;SER H  70;ILE H  29;ASP H  32","None","0.89A","1jg4A-5ukpH:undetectable","1jg4A-5ukpH:undetectable"],["1N2X_B_SAMB402_0","S-ADENOSYL-METHYLTRANSFERASE MRAW","5ukp","DH522.1 FAB FRAGMENT HEAVY CHAIN","Macaca mulatta",5,"GLY H  52;GLY H  55;GLY H  56;ASP H  31;GLY H  95","None","0.80A","1n2xB-5ukpH:undetectable","1n2xB-5ukpH:undetectable"],["2Y03_A_5FWA601_1","BETA-1 ADRENERGIC RECEPTOR","5ukp","DH522.1 FAB FRAGMENT HEAVY CHAIN","Macaca mulatta",5,"VAL H 163;VAL H 182;SER H 180;ASN H 197;ASN H 155","None","1.45A","2y03A-5ukpH:undetectable","2y03A-5ukpH:13.80"],["2Y03_B_5FWB601_1","BETA-1 ADRENERGIC RECEPTOR","5ukp","DH522.1 FAB FRAGMENT HEAVY CHAIN","Macaca mulatta",5,"VAL H 163;VAL H 182;SER H 180;ASN H 197;ASN H 155","None","1.49A","2y03B-5ukpH:undetectable","2y03B-5ukpH:13.80"],["4LDO_A_ALEA1402_1","LYSOZYME, BETA-2 ADRENERGIC RECEPTOR","5ukp","DH522.1 FAB FRAGMENT HEAVY CHAIN","Macaca mulatta",5,"VAL H 163;VAL H 182;SER H 180;ASN H 197;ASN H 155","None","1.48A","4ldoA-5ukpH:undetectable","4ldoA-5ukpH:12.50"],["4MMD_A_29EA603_1","TRANSPORTER","5ukp","DH522.1 FAB FRAGMENT HEAVY CHAIN","Macaca mulatta",5,"ASP H  32;TYR H  97;GLY H  52;SER H  96;GLY H  95","None","1.07A","4mmdA-5ukpH:undetectable","4mmdA-5ukpH:11.84"],["4MMD_B_29EB603_1","TRANSPORTER","5ukp","DH522.1 FAB FRAGMENT HEAVY CHAIN","Macaca mulatta",5,"ASP H  32;TYR H  97;GLY H  52;SER H  96;GLY H  95","None","1.08A","4mmdB-5ukpH:undetectable","4mmdB-5ukpH:11.84"],["6H7M_B_68HB405_0","BETA-1 ADRENERGIC RECEPTOR","5ukp","DH522.1 FAB FRAGMENT HEAVY CHAIN","Macaca mulatta",5,"VAL H 163;VAL H 182;SER H 180;ASN H 197;ASN H 155","None","1.44A","6h7mB-5ukpH:undetectable","6h7mB-5ukpH:22.92"]]