SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ukw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ6_A_CAMA502_0
(CYTOCHROME P450-CAM)		 5ukw GLUCOSE-6-PHOSPHATE
1-DEHYDROGENASE
(Homo
sapiens) 		4 / 5 PHE A 452
TYR A 197
LEU A 137
ASP A 443
 None
 1.40A 1dz6A-5ukwA:
undetectable		 1dz6A-5ukwA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E3V_B_DXCB801_0
(STEROID
DELTA-ISOMERASE)		 5ukw GLUCOSE-6-PHOSPHATE
1-DEHYDROGENASE
(Homo
sapiens) 		5 / 11 TYR A 503
LEU A 362
ASP A 493
MET A 496
ALA A 492
 None
 1.28A 1e3vB-5ukwA:
undetectable		 1e3vB-5ukwA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_B_DMEB996_1
(ACETYLCHOLINESTERASE)		 5ukw GLUCOSE-6-PHOSPHATE
1-DEHYDROGENASE
(Homo
sapiens) 		4 / 6 GLU A 156
ILE A  35
TYR A  70
GLY A  38
 None
 1.05A 1maaB-5ukwA:
2.3
1maaD-5ukwA:
1.8		 1maaB-5ukwA:
20.28
1maaD-5ukwA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_H_BEZH515_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5ukw GLUCOSE-6-PHOSPHATE
1-DEHYDROGENASE
(Homo
sapiens) 		4 / 6 ARG A 387
ALA A 231
ILE A 355
PRO A 353
 None
 1.07A 1oniH-5ukwA:
undetectable
1oniI-5ukwA:
0.7		 1oniH-5ukwA:
15.20
1oniI-5ukwA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2001_1
(SERUM ALBUMIN)		 5ukw GLUCOSE-6-PHOSPHATE
1-DEHYDROGENASE
(Homo
sapiens) 		5 / 11 ILE A 355
VAL A 499
GLY A 500
CYH A 232
LEU A 495
 None
 1.38A 2bxeA-5ukwA:
undetectable		 2bxeA-5ukwA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_2
(NEURAMINIDASE A)		 5ukw GLUCOSE-6-PHOSPHATE
1-DEHYDROGENASE
(Homo
sapiens) 		4 / 6 ARG A 246
GLN A 395
GLU A 239
TYR A 202
 None
BG6  A 601 (-3.2A)
BG6  A 601 (-2.9A)
BG6  A 601 (-4.8A)
 1.42A 2ya7C-5ukwA:
undetectable		 2ya7C-5ukwA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_B_H3PB552_1
(GLUTAMATE
DEHYDROGENASE)		 5ukw GLUCOSE-6-PHOSPHATE
1-DEHYDROGENASE
(Homo
sapiens) 		3 / 3 TYR A 107
TYR A  49
ILE A  36
 None
 0.71A 3eteA-5ukwA:
undetectable
3eteB-5ukwA:
2.0		 3eteA-5ukwA:
23.76
3eteB-5ukwA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE201_1
(PROTEIN S100-A4)		 5ukw GLUCOSE-6-PHOSPHATE
1-DEHYDROGENASE
(Homo
sapiens) 		4 / 7 PHE A  56
GLY A  59
PHE A  34
PHE A 445
 None
 1.06A 3ko0D-5ukwA:
undetectable
3ko0E-5ukwA:
undetectable		 3ko0D-5ukwA:
10.78
3ko0E-5ukwA:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 5ukw GLUCOSE-6-PHOSPHATE
1-DEHYDROGENASE
(Homo
sapiens) 		6 / 12 GLY A  38
GLY A  41
ILE A  48
LEU A 142
PRO A 143
VAL A 146
 None
 0.64A 4gc9A-5ukwA:
4.1		 4gc9A-5ukwA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJK_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5ukw GLUCOSE-6-PHOSPHATE
1-DEHYDROGENASE
(Homo
sapiens) 		5 / 12 ILE A 168
ALA A 141
THR A 151
ILE A 154
ILE A 167
 None
 1.10A 4kjkA-5ukwA:
undetectable		 4kjkA-5ukwA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_A_8PRA603_1
(TRANSPORTER)		 5ukw GLUCOSE-6-PHOSPHATE
1-DEHYDROGENASE
(Homo
sapiens) 		5 / 12 TYR A 482
ALA A 318
GLY A 485
ASP A 325
THR A 243
 None
 1.31A 4mm4A-5ukwA:
undetectable		 4mm4A-5ukwA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSE_C_HQEC1583_1
(UREASE SUBUNIT ALPHA)		 5ukw GLUCOSE-6-PHOSPHATE
1-DEHYDROGENASE
(Homo
sapiens) 		4 / 5 ILE A 234
GLN A 372
ARG A 370
CYH A 232
 None
 1.34A 5fseC-5ukwA:
1.3		 5fseC-5ukwA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA602_1
(CHITINASE)		 5ukw GLUCOSE-6-PHOSPHATE
1-DEHYDROGENASE
(Homo
sapiens) 		3 / 3 TRP A  53
GLU A  94
ASP A  58
 None
 0.83A 5gqbA-5ukwA:
undetectable		 5gqbA-5ukwA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_D_ACTD803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 5ukw GLUCOSE-6-PHOSPHATE
1-DEHYDROGENASE
(Homo
sapiens) 		4 / 4 GLU A 475
PRO A 477
ILE A 472
LEU A 474
 None
 1.32A 5m45D-5ukwA:
undetectable		 5m45D-5ukwA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 5ukw GLUCOSE-6-PHOSPHATE
1-DEHYDROGENASE
(Homo
sapiens) 		5 / 10 PHE A  34
LEU A 137
GLY A  69
ILE A  36
ILE A 168
 None
 1.10A 6ebpD-5ukwA:
undetectable		 6ebpD-5ukwA:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_F_AM2F301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5ukw GLUCOSE-6-PHOSPHATE
1-DEHYDROGENASE
(Homo
sapiens) 		4 / 7 ARG A 285
HIS A 451
GLU A 457
GLU A 193
 None
 1.33A 6mn4F-5ukwA:
undetectable		 6mn4F-5ukwA:
20.82