SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ul4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
5ul4 OXSB PROTEIN
(Bacillus
megaterium)
5 / 12 LEU A 157
ILE A 181
LEU A 183
ILE A 196
ILE A 213
None
0.91A 1oipA-5ul4A:
undetectable
1oipA-5ul4A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_F_BEZF5023_0
(CES1 PROTEIN)
5ul4 OXSB PROTEIN
(Bacillus
megaterium)
4 / 6 LEU A 157
GLY A 141
SER A 145
LEU A 136
None
0.94A 1yajF-5ul4A:
4.0
1yajF-5ul4A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_A_SALA506_1
(SALICYLATE
SYNTHETASE, IRP9)
5ul4 OXSB PROTEIN
(Bacillus
megaterium)
5 / 11 ILE A 366
GLU A 415
GLY A 372
GLY A 367
GLU A 368
None
1.34A 2fn1A-5ul4A:
undetectable
2fn1A-5ul4A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_B_SALB503_1
(SALICYLATE
SYNTHETASE, IRP9)
5ul4 OXSB PROTEIN
(Bacillus
megaterium)
5 / 11 ILE A 366
GLU A 415
GLY A 372
GLY A 367
GLU A 368
None
1.34A 2fn1B-5ul4A:
undetectable
2fn1B-5ul4A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)
5ul4 OXSB PROTEIN
(Bacillus
megaterium)
4 / 8 THR A 142
PRO A 290
LEU A 136
THR A 280
B12  A 802 ( 4.2A)
None
None
EDO  A 807 (-3.0A)
1.20A 2v0zO-5ul4A:
undetectable
2v0zO-5ul4A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VJ1_A_BEZA1303_0
(SARS CORONAVIRUS
MAIN PROTEINASE)
5ul4 OXSB PROTEIN
(Bacillus
megaterium)
3 / 3 HIS A 633
MET A 697
MET A 608
None
0.73A 2vj1A-5ul4A:
undetectable
2vj1A-5ul4A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_C_SALC1302_1
(LYSR-TYPE REGULATORY
PROTEIN)
5ul4 OXSB PROTEIN
(Bacillus
megaterium)
5 / 12 ILE A 298
GLY A 296
GLY A 349
ARG A 302
ILE A 354
None
1.24A 2y7kC-5ul4A:
undetectable
2y7kC-5ul4A:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_D_SALD1300_1
(LYSR-TYPE REGULATORY
PROTEIN)
5ul4 OXSB PROTEIN
(Bacillus
megaterium)
5 / 12 ILE A 298
GLY A 296
GLY A 349
LEU A 305
ILE A 354
None
1.20A 2y7kD-5ul4A:
undetectable
2y7kD-5ul4A:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_B_SALB1300_1
(LYSR-TYPE REGULATORY
PROTEIN)
5ul4 OXSB PROTEIN
(Bacillus
megaterium)
5 / 10 ILE A 298
GLY A 296
GLY A 349
PRO A 134
ILE A 354
None
1.33A 2y7wB-5ul4A:
1.2
2y7wB-5ul4A:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_D_VDYD6178_1
(VITAMIN D
HYDROXYLASE)
5ul4 OXSB PROTEIN
(Bacillus
megaterium)
5 / 12 ILE A 213
ASN A 137
LEU A 197
ILE A 196
LEU A 173
None
1.16A 3a51D-5ul4A:
2.5
3a51D-5ul4A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB501_1
(PHOSPHOLIPASE A2)
5ul4 OXSB PROTEIN
(Bacillus
megaterium)
4 / 4 SER A 223
PRO A 224
PHE A 227
PRO A 220
None
1.38A 3bjwA-5ul4A:
undetectable
3bjwA-5ul4A:
10.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE503_2
(PHOSPHOLIPASE A2)
5ul4 OXSB PROTEIN
(Bacillus
megaterium)
4 / 4 SER A 223
PRO A 224
PHE A 227
PRO A 220
None
1.39A 3bjwG-5ul4A:
undetectable
3bjwG-5ul4A:
10.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH504_1
(PHOSPHOLIPASE A2)
5ul4 OXSB PROTEIN
(Bacillus
megaterium)
4 / 4 SER A 223
PRO A 224
PHE A 227
PRO A 220
None
1.38A 3bjwD-5ul4A:
undetectable
3bjwD-5ul4A:
10.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)
5ul4 OXSB PROTEIN
(Bacillus
megaterium)
4 / 6 VAL A 123
LEU A 138
ILE A 166
ILE A 158
None
B12  A 802 ( 4.0A)
None
None
0.91A 3gcsA-5ul4A:
undetectable
3gcsA-5ul4A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)
5ul4 OXSB PROTEIN
(Bacillus
megaterium)
4 / 6 LEU A 385
ILE A 358
THR A 309
THR A 338
None
1.08A 3mdrA-5ul4A:
undetectable
3mdrA-5ul4A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB323_0
(INVASIN IPAD)
5ul4 OXSB PROTEIN
(Bacillus
megaterium)
4 / 7 LEU A 292
ILE A 358
ILE A 392
LEU A 342
None
0.64A 3r9vA-5ul4A:
2.8
3r9vB-5ul4A:
undetectable
3r9vA-5ul4A:
18.01
3r9vB-5ul4A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)
5ul4 OXSB PROTEIN
(Bacillus
megaterium)
4 / 6 LEU A 721
SER A 716
ARG A 720
LEU A 708
None
1.16A 3rd0A-5ul4A:
2.9
3rd0A-5ul4A:
13.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA1_1
(CYTOCHROME P450 2D6)
5ul4 OXSB PROTEIN
(Bacillus
megaterium)
5 / 12 LEU A 486
PHE A 492
LEU A 493
LEU A 443
GLN A 442
None
None
EDO  A 814 (-3.7A)
None
None
1.35A 3tbgA-5ul4A:
2.3
3tbgA-5ul4A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_A_QPSA951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)
5ul4 OXSB PROTEIN
(Bacillus
megaterium)
4 / 6 GLY A 141
ARG A 135
GLU A 308
ARG A 311
None
B12  A 802 ( 3.2A)
B12  A 802 (-3.4A)
B12  A 802 (-3.3A)
1.36A 4bqfA-5ul4A:
4.9
4bqfA-5ul4A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)
5ul4 OXSB PROTEIN
(Bacillus
megaterium)
5 / 10 VAL A 120
LEU A 147
VAL A 155
LEU A 143
THR A 140
None
None
None
B12  A 802 ( 4.7A)
None
1.03A 4e3hA-5ul4A:
undetectable
4e3hA-5ul4A:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_B_ADNB401_2
(ADENOSINE KINASE)
5ul4 OXSB PROTEIN
(Bacillus
megaterium)
4 / 5 LEU A 541
SER A 594
LEU A 486
LEU A 640
EDO  A 814 (-4.8A)
None
None
None
1.28A 4n09B-5ul4A:
5.9
4n09B-5ul4A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_D_ADND401_2
(ADENOSINE KINASE)
5ul4 OXSB PROTEIN
(Bacillus
megaterium)
4 / 5 LEU A 541
SER A 594
LEU A 486
LEU A 640
EDO  A 814 (-4.8A)
None
None
None
1.27A 4n09D-5ul4A:
5.8
4n09D-5ul4A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA602_1
(SERUM ALBUMIN)
5ul4 OXSB PROTEIN
(Bacillus
megaterium)
4 / 6 ARG A 399
ALA A 398
ASP A 401
SER A 310
None
1.07A 4ot2A-5ul4A:
undetectable
4ot2A-5ul4A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)
5ul4 OXSB PROTEIN
(Bacillus
megaterium)
5 / 12 GLU A 364
CYH A 318
ARG A 317
ALA A 400
ASP A 401
None
SF4  A 801 (-2.2A)
None
None
None
1.13A 4qrcA-5ul4A:
undetectable
4qrcA-5ul4A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_A_HISA302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)
5ul4 OXSB PROTEIN
(Bacillus
megaterium)
5 / 10 GLY A 216
VAL A 215
THR A 140
VAL A 185
LEU A 122
B12  A 802 (-3.6A)
None
None
None
None
1.32A 4yb6A-5ul4A:
undetectable
4yb6E-5ul4A:
undetectable
4yb6A-5ul4A:
20.00
4yb6E-5ul4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_B_HISB302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)
5ul4 OXSB PROTEIN
(Bacillus
megaterium)
5 / 10 GLY A 216
VAL A 215
THR A 140
VAL A 185
LEU A 122
B12  A 802 (-3.6A)
None
None
None
None
1.30A 4yb6B-5ul4A:
undetectable
4yb6C-5ul4A:
undetectable
4yb6B-5ul4A:
20.00
4yb6C-5ul4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_C_HISC302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)
5ul4 OXSB PROTEIN
(Bacillus
megaterium)
5 / 10 GLY A 216
VAL A 215
THR A 140
VAL A 185
LEU A 122
B12  A 802 (-3.6A)
None
None
None
None
1.31A 4yb6C-5ul4A:
undetectable
4yb6F-5ul4A:
undetectable
4yb6C-5ul4A:
20.00
4yb6F-5ul4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_D_HISD302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)
5ul4 OXSB PROTEIN
(Bacillus
megaterium)
5 / 10 LEU A 122
GLY A 216
VAL A 215
THR A 140
VAL A 185
None
B12  A 802 (-3.6A)
None
None
None
1.31A 4yb6A-5ul4A:
undetectable
4yb6D-5ul4A:
undetectable
4yb6A-5ul4A:
20.00
4yb6D-5ul4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_E_HISE302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)
5ul4 OXSB PROTEIN
(Bacillus
megaterium)
5 / 10 LEU A 122
GLY A 216
VAL A 215
THR A 140
VAL A 185
None
B12  A 802 (-3.6A)
None
None
None
1.29A 4yb6D-5ul4A:
undetectable
4yb6E-5ul4A:
undetectable
4yb6D-5ul4A:
20.00
4yb6E-5ul4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_F_HISF302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)
5ul4 OXSB PROTEIN
(Bacillus
megaterium)
5 / 10 LEU A 122
GLY A 216
VAL A 215
THR A 140
VAL A 185
None
B12  A 802 (-3.6A)
None
None
None
1.30A 4yb6B-5ul4A:
undetectable
4yb6F-5ul4A:
undetectable
4yb6B-5ul4A:
20.00
4yb6F-5ul4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_2
(CALCINEURIN SUBUNIT
B, VARIANT
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)
5ul4 OXSB PROTEIN
(Bacillus
megaterium)
4 / 4 LEU A 644
MET A 690
VAL A 689
ASN A 688
None
1.39A 5b8iB-5ul4A:
1.1
5b8iB-5ul4A:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_X_BEZX801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)
5ul4 OXSB PROTEIN
(Bacillus
megaterium)
4 / 5 ILE A 158
GLY A 182
ILE A 169
LEU A 122
None
B12  A 802 (-3.4A)
None
None
0.86A 5dzki-5ul4A:
undetectable
5dzkj-5ul4A:
undetectable
5dzkx-5ul4A:
undetectable
5dzki-5ul4A:
13.31
5dzkj-5ul4A:
13.31
5dzkx-5ul4A:
2.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Z_BEZZ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)
5ul4 OXSB PROTEIN
(Bacillus
megaterium)
4 / 4 ILE A 158
GLY A 182
ILE A 169
LEU A 122
None
B12  A 802 (-3.4A)
None
None
0.86A 5dzkl-5ul4A:
undetectable
5dzkz-5ul4A:
undetectable
5dzkl-5ul4A:
13.31
5dzkz-5ul4A:
2.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVO_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
5ul4 OXSB PROTEIN
(Bacillus
megaterium)
3 / 3 ARG A 702
VAL A 607
TRP A 728
None
1.25A 5fvoA-5ul4A:
undetectable
5fvoA-5ul4A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G08_A_Z80A1187_1
(FREQUENIN 2)
5ul4 OXSB PROTEIN
(Bacillus
megaterium)
4 / 6 ILE A 546
TYR A 552
PHE A 320
PHE A 585
None
None
SAM  A 803 (-4.5A)
None
1.23A 5g08A-5ul4A:
1.5
5g08A-5ul4A:
13.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UL4_A_SAMA803_0
(OXSB PROTEIN)
5ul4 OXSB PROTEIN
(Bacillus
megaterium)
12 / 12 PHE A 320
ALA A 397
ARG A 399
PHE A 432
GLY A 434
GLU A 436
LYS A 448
GLY A 472
ILE A 474
MET A 544
GLU A 545
LEU A 547
SAM  A 803 (-4.5A)
SAM  A 803 (-3.4A)
None
SAM  A 803 (-3.6A)
SAM  A 803 (-3.2A)
SAM  A 803 (-2.5A)
SAM  A 803 (-3.3A)
SAM  A 803 (-3.2A)
SAM  A 803 (-4.2A)
SAM  A 803 (-3.7A)
B12  A 802 (-4.4A)
SAM  A 803 ( 4.4A)
0.00A 5ul4A-5ul4A:
62.3
5ul4A-5ul4A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UL4_A_SAMA803_0
(OXSB PROTEIN)
5ul4 OXSB PROTEIN
(Bacillus
megaterium)
5 / 12 PHE A 320
ALA A 398
GLY A 434
GLU A 436
GLY A 472
SAM  A 803 (-4.5A)
None
SAM  A 803 (-3.2A)
SAM  A 803 (-2.5A)
SAM  A 803 (-3.2A)
1.04A 5ul4A-5ul4A:
62.3
5ul4A-5ul4A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11803_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
EL18)
5ul4 OXSB PROTEIN
(Bacillus
megaterium)
3 / 3 SER A   9
LYS A   8
SER A   6
None
0.73A 6az3P-5ul4A:
undetectable
6az3P-5ul4A:
8.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_2
(-)
5ul4 OXSB PROTEIN
(Bacillus
megaterium)
5 / 12 LEU A 147
LEU A 152
GLY A 241
ASN A  58
LYS A 149
None
None
B12  A 802 (-3.5A)
None
None
0.98A 6ce2B-5ul4A:
undetectable
6ce2B-5ul4A:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_D_ADND502_2
(-)
5ul4 OXSB PROTEIN
(Bacillus
megaterium)
4 / 5 ILE A 345
GLN A 337
THR A 289
LEU A 385
None
EDO  A 811 (-4.5A)
None
None
1.06A 6f3mD-5ul4A:
3.5
6f3mD-5ul4A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)
5ul4 OXSB PROTEIN
(Bacillus
megaterium)
4 / 8 SER A 553
MET A 548
SER A 265
ASN A 549
None
0.88A 6giqL-5ul4A:
undetectable
6giqP-5ul4A:
undetectable
6giqT-5ul4A:
undetectable
6giqL-5ul4A:
20.75
6giqP-5ul4A:
14.16
6giqT-5ul4A:
6.42