SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ulm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_D_ESTD352_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 5ulm MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5
(Homo
sapiens) 		4 / 6 VAL A 478
GLY A 479
TYR A 510
GLU A 499
 None
 1.01A 1fduD-5ulmA:
undetectable		 1fduD-5ulmA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 5ulm MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5
(Homo
sapiens) 		4 / 5 ILE A 315
ARG A 281
LEU A 319
ASN A 316
 None
 1.06A 1y0xX-5ulmA:
undetectable		 1y0xX-5ulmA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3K_A_SAMA1254_0
(ESSENTIAL FOR
MITOTIC GROWTH 1)		 5ulm MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5
(Homo
sapiens) 		6 / 10 LEU A 429
GLY A 479
GLY A 432
LEU A 459
LEU A 487
ALA A 484
 None
 1.35A 2v3kA-5ulmA:
undetectable		 2v3kA-5ulmA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5ulm MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5
(Homo
sapiens) 		4 / 5 LYS A 512
ILE A 520
LEU A 392
ASP A 399
 None
 0.99A 3wzdA-5ulmA:
undetectable		 3wzdA-5ulmA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NX7_A_FOLA202_1
(DIHYDROFOLATE
REDUCTASE)		 5ulm MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5
(Homo
sapiens) 		4 / 4 ILE A 306
ASP A 312
ARG A 302
THR A 310
 None
 1.35A 4nx7A-5ulmA:
undetectable		 4nx7A-5ulmA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_2_BEZ2801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 5ulm MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5
(Homo
sapiens) 		4 / 4 LEU A 277
ARG A 302
ILE A 276
ILE A 299
 None
 1.42A 5dzk2-5ulmA:
undetectable
5dzkM-5ulmA:
undetectable
5dzkN-5ulmA:
undetectable		 5dzk2-5ulmA:
3.77
5dzkM-5ulmA:
19.90
5dzkN-5ulmA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H1E_A_VDXA501_1
(VITAMIN D3 RECEPTOR)		 5ulm MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5
(Homo
sapiens) 		5 / 12 LEU A 333
ILE A 313
SER A 320
VAL A 351
HIS A 348
 None
 1.37A 5h1eA-5ulmA:
undetectable		 5h1eA-5ulmA:
26.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J6H_A_NCAA402_0
(H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, Q10 ALPHA
CHAIN)		 5ulm MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5
(Homo
sapiens) 		3 / 3 PRO A 560
ARG A 558
GLU A 548
 None
 0.75A 5j6hA-5ulmA:
undetectable		 5j6hA-5ulmA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)		 5ulm MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5
(Homo
sapiens) 		5 / 9 VAL A 494
ALA A 497
SER A 498
VAL A 486
GLY A 479
 None
 1.03A 6bklA-5ulmA:
undetectable
6bklB-5ulmA:
undetectable
6bklC-5ulmA:
undetectable
6bklD-5ulmA:
undetectable		 6bklA-5ulmA:
5.51
6bklB-5ulmA:
5.51
6bklC-5ulmA:
5.51
6bklD-5ulmA:
5.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8F_A_ACTA803_0
(UNCHARACTERIZED
PROTEIN)		 5ulm MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5
(Homo
sapiens) 		3 / 3 GLU A 274
LEU A 277
ARG A 281
 None
 0.46A 6d8fA-5ulmA:
undetectable		 6d8fA-5ulmA:
18.49