SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5um0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_A_IBPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 5um0 2,3-BISPHOSPHOGLYCER
ATE-DEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Neisseria
gonorrhoeae) 		5 / 9 VAL A   4
VAL A  67
LEU A  42
ALA A 179
LEU A 177
 None
 1.20A 1eqgA-5um0A:
undetectable		 1eqgA-5um0A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_F_CCSF47_0
(GLUTATHIONE
S-TRANSFERASE)		 5um0 2,3-BISPHOSPHOGLYCER
ATE-DEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Neisseria
gonorrhoeae) 		4 / 5 THR A  20
LEU A  92
GLY A  94
LYS A  97
 TLA  A 300 (-3.9A)
None
None
TLA  A 300 (-2.9A)
 1.23A 1gtiF-5um0A:
undetectable		 1gtiF-5um0A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1300_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 5um0 2,3-BISPHOSPHOGLYCER
ATE-DEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Neisseria
gonorrhoeae) 		5 / 11 GLY A 182
SER A 184
ALA A  60
LEU A  57
VAL A 178
 None
 1.00A 1ukbA-5um0A:
undetectable		 1ukbA-5um0A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_B_IBPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5um0 2,3-BISPHOSPHOGLYCER
ATE-DEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Neisseria
gonorrhoeae) 		5 / 10 VAL A   4
VAL A  67
LEU A  42
ALA A 179
LEU A 177
 None
 1.13A 4ph9B-5um0A:
undetectable		 4ph9B-5um0A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_C_ACTC401_0
(PROTON-GATED ION
CHANNEL)		 5um0 2,3-BISPHOSPHOGLYCER
ATE-DEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Neisseria
gonorrhoeae) 		4 / 7 ILE A 166
PHE A 161
VAL A 176
ILE A  51
 None
 0.97A 4zzbC-5um0A:
undetectable
4zzbD-5um0A:
undetectable		 4zzbC-5um0A:
22.29
4zzbD-5um0A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NO9_D_95ZD302_1
(25 KDA PROTEIN
ELICITOR)		 5um0 2,3-BISPHOSPHOGLYCER
ATE-DEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Neisseria
gonorrhoeae) 		4 / 7 GLY A 148
HIS A  88
HIS A 132
ASP A 147
 None
 1.05A 5no9D-5um0A:
undetectable		 5no9D-5um0A:
16.24