SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5um2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_A_VIBA502_1
(THIAMIN
PYROPHOSPHOKINASE)		 5um2 ABC TRANSPORTER
SULFATE BINDING
PROTEIN
(Xanthomonas
citri) 		4 / 8 TRP A 244
LEU A 241
ASN A 188
THR A 181
 SO4  A 401 (-3.9A)
None
None
None
 1.10A 1ig3A-5um2A:
undetectable
1ig3B-5um2A:
undetectable		 1ig3A-5um2A:
25.07
1ig3B-5um2A:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_C_X2NC1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 5um2 ABC TRANSPORTER
SULFATE BINDING
PROTEIN
(Xanthomonas
citri) 		5 / 12 PHE A 151
VAL A 240
ALA A 194
ALA A 196
LEU A 168
 None
 1.11A 2x2nC-5um2A:
undetectable		 2x2nC-5um2A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_A_ACTA1467_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 5um2 ABC TRANSPORTER
SULFATE BINDING
PROTEIN
(Xanthomonas
citri) 		4 / 5 ARG A 288
ASP A 279
ILE A 130
GLU A 292
 None
 1.32A 2xrzA-5um2A:
undetectable
2xrzB-5um2A:
undetectable		 2xrzA-5um2A:
23.78
2xrzB-5um2A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5um2 ABC TRANSPORTER
SULFATE BINDING
PROTEIN
(Xanthomonas
citri) 		5 / 12 LEU A 190
TRP A 343
SER A 268
GLY A 183
ALA A 185
 None
None
None
SO4  A 401 (-3.5A)
None
 1.12A 3kk6A-5um2A:
undetectable		 3kk6A-5um2A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_1
(CYTOCHROME P450 3A4)		 5um2 ABC TRANSPORTER
SULFATE BINDING
PROTEIN
(Xanthomonas
citri) 		5 / 12 PHE A 351
ILE A 269
ALA A 271
ALA A 225
GLY A  97
 None
None
None
SO4  A 401 (-3.4A)
GOL  A 403 ( 3.1A)
 0.99A 3nxuA-5um2A:
undetectable		 3nxuA-5um2A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5um2 ABC TRANSPORTER
SULFATE BINDING
PROTEIN
(Xanthomonas
citri) 		5 / 12 ALA A 225
GLY A 184
GLY A  95
SER A  96
ALA A 243
 SO4  A 401 (-3.4A)
SO4  A 401 (-3.3A)
SO4  A 401 (-3.6A)
SO4  A 401 (-4.4A)
None
 0.91A 3ou6A-5um2A:
undetectable		 3ou6A-5um2A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5um2 ABC TRANSPORTER
SULFATE BINDING
PROTEIN
(Xanthomonas
citri) 		5 / 12 TYR A  60
ALA A 225
GLY A 184
GLY A  95
ALA A 243
 SO4  A 401 (-4.7A)
SO4  A 401 (-3.4A)
SO4  A 401 (-3.3A)
SO4  A 401 (-3.6A)
None
 1.09A 3ou6A-5um2A:
undetectable		 3ou6A-5um2A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5um2 ABC TRANSPORTER
SULFATE BINDING
PROTEIN
(Xanthomonas
citri) 		5 / 12 ALA A 225
GLY A 184
GLY A  95
SER A  96
ALA A 243
 SO4  A 401 (-3.4A)
SO4  A 401 (-3.3A)
SO4  A 401 (-3.6A)
SO4  A 401 (-4.4A)
None
 0.89A 3ou6B-5um2A:
undetectable		 3ou6B-5um2A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5um2 ABC TRANSPORTER
SULFATE BINDING
PROTEIN
(Xanthomonas
citri) 		5 / 12 TYR A  60
ALA A 225
GLY A 184
GLY A  95
ALA A 243
 SO4  A 401 (-4.7A)
SO4  A 401 (-3.4A)
SO4  A 401 (-3.3A)
SO4  A 401 (-3.6A)
None
 1.09A 3ou6B-5um2A:
undetectable		 3ou6B-5um2A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5um2 ABC TRANSPORTER
SULFATE BINDING
PROTEIN
(Xanthomonas
citri) 		5 / 12 ALA A 225
GLY A 184
GLY A  95
SER A  96
ALA A 243
 SO4  A 401 (-3.4A)
SO4  A 401 (-3.3A)
SO4  A 401 (-3.6A)
SO4  A 401 (-4.4A)
None
 0.90A 3ou7B-5um2A:
undetectable		 3ou7B-5um2A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZV_B_ECNB411_1
(FLAVOHEMOGLOBIN)		 5um2 ABC TRANSPORTER
SULFATE BINDING
PROTEIN
(Xanthomonas
citri) 		5 / 9 ILE A 336
ILE A 269
ALA A 192
LEU A 190
LEU A 116
 None
 1.07A 3ozvB-5um2A:
undetectable		 3ozvB-5um2A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHN_A_ACTA108_0
(PROTEIN P-30)		 5um2 ABC TRANSPORTER
SULFATE BINDING
PROTEIN
(Xanthomonas
citri) 		3 / 3 THR A 148
SER A 147
ARG A 313
 None
 0.79A 3phnA-5um2A:
undetectable		 3phnA-5um2A:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_C_SVRC516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 5um2 ABC TRANSPORTER
SULFATE BINDING
PROTEIN
(Xanthomonas
citri) 		5 / 9 GLY A 183
ALA A 185
ALA A 228
ASP A 222
LEU A 221
 SO4  A 401 (-3.5A)
None
None
None
None
 1.46A 3ur0C-5um2A:
undetectable		 3ur0C-5um2A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_C_SVRC516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 5um2 ABC TRANSPORTER
SULFATE BINDING
PROTEIN
(Xanthomonas
citri) 		5 / 9 GLY A 184
ALA A 185
ALA A 228
ASP A 222
LEU A 221
 SO4  A 401 (-3.3A)
None
None
None
None
 1.39A 3ur0C-5um2A:
undetectable		 3ur0C-5um2A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9K_A_TYLA2200_1
(CREB-BINDING PROTEIN)		 5um2 ABC TRANSPORTER
SULFATE BINDING
PROTEIN
(Xanthomonas
citri) 		5 / 6 VAL A 111
LEU A 295
TYR A  67
ASN A  71
VAL A  89
 None
 1.33A 4a9kA-5um2A:
undetectable		 4a9kA-5um2A:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIX_A_NIMA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 5um2 ABC TRANSPORTER
SULFATE BINDING
PROTEIN
(Xanthomonas
citri) 		4 / 4 LEU A 267
ALA A 196
ILE A 199
LYS A 332
 None
 1.37A 4eixA-5um2A:
undetectable		 4eixA-5um2A:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_2
(ANDROGEN RECEPTOR)		 5um2 ABC TRANSPORTER
SULFATE BINDING
PROTEIN
(Xanthomonas
citri) 		4 / 6 LEU A  55
ASN A  57
LEU A 277
VAL A 120
 None
 1.03A 4okbA-5um2A:
undetectable		 4okbA-5um2A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5um2 ABC TRANSPORTER
SULFATE BINDING
PROTEIN
(Xanthomonas
citri) 		4 / 8 THR A 113
GLY A  94
GLY A  95
ASP A 119
 None
None
SO4  A 401 (-3.6A)
GOL  A 403 (-2.5A)
 0.83A 4qvvY-5um2A:
undetectable
4qvvZ-5um2A:
undetectable		 4qvvY-5um2A:
17.01
4qvvZ-5um2A:
22.70