SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5um6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3009_0
(BETA-CARBONIC
ANHYDRASE)		 5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1
(Schizosaccharomy
ces
pombe) 		4 / 5 GLY A 563
LEU A 562
THR A 561
VAL A 852
 None
 1.01A 1ekjF-5um6A:
2.9
1ekjG-5um6A:
1.4		 1ekjF-5um6A:
11.83
1ekjG-5um6A:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1
(Schizosaccharomy
ces
pombe) 		3 / 3 SER A 517
GLU A 518
GLU A 983
 None
 0.49A 1eqbD-5um6A:
undetectable		 1eqbD-5um6A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1
(Schizosaccharomy
ces
pombe) 		3 / 3 SER A 517
GLU A 518
GLU A 983
 None
 0.50A 1eqbB-5um6A:
undetectable		 1eqbB-5um6A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM4_A_DXCA1001_0
(MAJOR POLLEN
ALLERGEN BET V 1-L)		 5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1
(Schizosaccharomy
ces
pombe) 		5 / 12 PHE A 677
PRO A 599
ILE A 836
ALA A 609
SER A 827
 None
 1.47A 1fm4A-5um6A:
undetectable		 1fm4A-5um6A:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1
(Schizosaccharomy
ces
pombe) 		4 / 6 SER A 358
GLY A  44
THR A 129
ILE A  42
 None
 0.89A 1gtnD-5um6A:
undetectable
1gtnE-5um6A:
undetectable		 1gtnD-5um6A:
5.27
1gtnE-5um6A:
5.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_1
(DNA GYRASE SUBUNIT B)		 5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1
(Schizosaccharomy
ces
pombe) 		5 / 12 ASP A 411
GLU A  75
ASP A  76
ILE A  88
THR A  72
 None
 1.38A 1kijA-5um6A:
undetectable		 1kijA-5um6A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1871_0
(FPRA)		 5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1
(Schizosaccharomy
ces
pombe) 		4 / 7 PHE A 822
ALA A 826
PHE A 724
PHE A 677
 None
 1.02A 1lqtA-5um6A:
3.7		 1lqtA-5um6A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1428_0
(FPRA)		 5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1
(Schizosaccharomy
ces
pombe) 		4 / 7 PHE A 822
ALA A 826
PHE A 724
PHE A 677
 None
 1.00A 1lquA-5um6A:
5.7		 1lquA-5um6A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMK_A_H4BA1427_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1
(Schizosaccharomy
ces
pombe) 		5 / 12 VAL A 416
LEU A 354
SER A 358
LEU A 361
GLU A 130
 None
 1.43A 1mmkA-5um6A:
undetectable		 1mmkA-5um6A:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_1
(HEMK PROTEIN)		 5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1
(Schizosaccharomy
ces
pombe) 		3 / 3 ASP A 208
PHE A 254
ASN A 178
 None
 0.73A 1sg9B-5um6A:
5.8		 1sg9B-5um6A:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_1
(SUN PROTEIN)		 5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1
(Schizosaccharomy
ces
pombe) 		3 / 3 PRO A  71
ASP A  68
ASP A  76
 None
 0.78A 1sqfA-5um6A:
4.0		 1sqfA-5um6A:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U70_A_MTXA187_2
(DIHYDROFOLATE
REDUCTASE)		 5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1
(Schizosaccharomy
ces
pombe) 		4 / 4 SER A 161
ILE A 162
VAL A 127
THR A 143
 None
 1.10A 1u70A-5um6A:
undetectable		 1u70A-5um6A:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_1
(DIPEPTIDYL PEPTIDASE
IV)		 5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1
(Schizosaccharomy
ces
pombe) 		5 / 12 GLU A 558
SER A 581
VAL A 513
ASN A 534
VAL A 433
 None
 1.43A 1x70A-5um6A:
2.0		 1x70A-5um6A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_1
(DIPEPTIDYL PEPTIDASE
IV)		 5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1
(Schizosaccharomy
ces
pombe) 		5 / 12 GLU A 558
SER A 581
VAL A 513
ASN A 534
VAL A 433
 None
 1.42A 1x70B-5um6A:
2.1		 1x70B-5um6A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y4L_B_SVRB301_2
(PHOSPHOLIPASE A2
HOMOLOG 2)		 5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1
(Schizosaccharomy
ces
pombe) 		5 / 11 LEU A 268
LEU A 272
GLY A 160
HIS A 292
TYR A 383
 None
 1.20A 1y4lB-5um6A:
undetectable		 1y4lB-5um6A:
7.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2001_1
(SERUM ALBUMIN)		 5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1
(Schizosaccharomy
ces
pombe) 		4 / 8 SER A 730
PHE A 822
ALA A 826
LEU A 612
 None
 0.92A 2bxmA-5um6A:
undetectable		 2bxmA-5um6A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C49_B_ADNB1301_1
(SUGAR KINASE MJ0406)		 5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1
(Schizosaccharomy
ces
pombe) 		5 / 7 ALA A 364
GLY A 362
GLY A 363
ASN A  55
PHE A 895
 None
 1.41A 2c49B-5um6A:
3.7		 2c49B-5um6A:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1
(Schizosaccharomy
ces
pombe) 		4 / 6 VAL A 974
SER A 947
LEU A1012
HIS A 988
 None
 1.27A 2f8dA-5um6A:
0.6		 2f8dA-5um6A:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JST_A_HLTA101_1
(FOUR-ALPHA-HELIX
BUNDLE)		 5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1
(Schizosaccharomy
ces
pombe) 		4 / 5 TRP A 669
ALA A 729
LEU A 672
ALA A 728
 None
 0.92A 2jstA-5um6A:
undetectable
2jstB-5um6A:
undetectable		 2jstA-5um6A:
4.69
2jstB-5um6A:
4.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OD9_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1
(Schizosaccharomy
ces
pombe) 		3 / 3 PHE A 384
PHE A 895
PHE A 897
 None
 0.73A 2od9A-5um6A:
2.1		 2od9A-5um6A:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OD9_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1
(Schizosaccharomy
ces
pombe) 		3 / 3 PHE A 897
PHE A 386
PHE A 384
 None
 0.83A 2od9A-5um6A:
2.1		 2od9A-5um6A:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		 5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1
(Schizosaccharomy
ces
pombe) 		4 / 7 ILE A 602
SER A 827
ARG A 610
ILE A 851
 None
 1.13A 2q6hA-5um6A:
1.3		 2q6hA-5um6A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQG_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1
(Schizosaccharomy
ces
pombe) 		3 / 3 PHE A 384
PHE A 895
PHE A 897
 None
 0.73A 2qqgA-5um6A:
2.1		 2qqgA-5um6A:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQG_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1
(Schizosaccharomy
ces
pombe) 		3 / 3 PHE A 897
PHE A 386
PHE A 384
 None
 0.83A 2qqgA-5um6A:
2.1		 2qqgA-5um6A:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		 5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1
(Schizosaccharomy
ces
pombe) 		4 / 8 SER A 629
SER A 110
THR A  65
LEU A 120
 None
 1.00A 2v0zO-5um6A:
undetectable		 2v0zO-5um6A:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_1
(UNCHARACTERIZED
PROTEIN PH0793)		 5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1
(Schizosaccharomy
ces
pombe) 		3 / 3 MET A 357
GLU A 869
ASP A 899
 None
 1.02A 3a25A-5um6A:
4.2		 3a25A-5um6A:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_E_VDYE6178_1
(VITAMIN D
HYDROXYLASE)		 5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1
(Schizosaccharomy
ces
pombe) 		5 / 12 ILE A 162
ILE A  52
ALA A 366
THR A 857
VAL A 861
 None
 1.24A 3a51E-5um6A:
2.3		 3a51E-5um6A:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_A_IMNA2_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1
(Schizosaccharomy
ces
pombe) 		5 / 12 TYR A 385
LEU A 338
PHE A 334
HIS A 292
LEU A 133
 None
 1.49A 3adxA-5um6A:
undetectable		 3adxA-5um6A:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_B_PAUB248_0
(TYPE III
PANTOTHENATE KINASE)		 5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1
(Schizosaccharomy
ces
pombe) 		5 / 12 LEU A 952
VAL A 949
GLY A 948
THR A 978
ILE A 977
 None
None
8E7  A1103 ( 4.4A)
None
None
 1.20A 3bf1A-5um6A:
2.4
3bf1B-5um6A:
undetectable		 3bf1A-5um6A:
13.92
3bf1B-5um6A:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJM_A_BJMA1_1
(DIPEPTIDYL PEPTIDASE
4)		 5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1
(Schizosaccharomy
ces
pombe) 		5 / 12 GLU A 558
TYR A 544
VAL A 513
ASN A 534
VAL A 433
 None
 1.47A 3bjmA-5um6A:
undetectable		 3bjmA-5um6A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_3
(PHOSPHOLIPASE A2)		 5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1
(Schizosaccharomy
ces
pombe) 		4 / 7 LYS A 424
ILE A 425
GLY A 450
LEU A 502
 None
 0.80A 3bjwF-5um6A:
undetectable		 3bjwF-5um6A:
8.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1
(Schizosaccharomy
ces
pombe) 		5 / 12 GLY A  44
GLY A  49
VAL A 128
ALA A  93
LEU A 115
 None
 1.32A 3dh0A-5um6A:
4.0		 3dh0A-5um6A:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_D_BRLD478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1
(Schizosaccharomy
ces
pombe) 		4 / 4 ILE A 151
GLN A 136
ILE A  42
LEU A 137
 None
 1.30A 3dzyD-5um6A:
0.0		 3dzyD-5um6A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_A_T22A800_1
(DIPEPTIDYL PEPTIDASE
4)		 5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1
(Schizosaccharomy
ces
pombe) 		5 / 12 GLU A 558
TYR A 544
VAL A 513
ASN A 534
VAL A 433
 None
 1.48A 3g0bA-5um6A:
2.5		 3g0bA-5um6A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_C_T22C800_1
(DIPEPTIDYL PEPTIDASE
4)		 5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1
(Schizosaccharomy
ces
pombe) 		5 / 12 GLU A 558
TYR A 544
VAL A 513
ASN A 534
VAL A 433
 None
 1.46A 3g0bC-5um6A:
undetectable		 3g0bC-5um6A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_D_T22D800_1
(DIPEPTIDYL PEPTIDASE
4)		 5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1
(Schizosaccharomy
ces
pombe) 		5 / 12 GLU A 558
TYR A 544
VAL A 513
ASN A 534
VAL A 433
 None
 1.46A 3g0bD-5um6A:
2.0		 3g0bD-5um6A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID800_0
(GLUTAMATE RECEPTOR 2)		 5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1
(Schizosaccharomy
ces
pombe) 		4 / 7 TYR A 383
ASN A 140
LEU A 268
ASP A 165
 None
 1.27A 3lslA-5um6A:
undetectable
3lslD-5um6A:
undetectable		 3lslA-5um6A:
14.19
3lslD-5um6A:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG800_0
(GLUTAMATE RECEPTOR 2)		 5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1
(Schizosaccharomy
ces
pombe) 		4 / 6 TYR A 383
ASN A 140
LEU A 268
ASP A 165
 None
 1.27A 3lslG-5um6A:
undetectable		 3lslG-5um6A:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_1
(FIV PROTEASE)		 5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1
(Schizosaccharomy
ces
pombe) 		5 / 10 LEU A 443
ILE A 425
GLY A 457
SER A 496
VAL A 495
 None
 1.02A 3ogpA-5um6A:
undetectable		 3ogpA-5um6A:
8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1
(Schizosaccharomy
ces
pombe) 		3 / 3 SER A 559
GLY A 560
GLN A 583
 None
 0.64A 3v4tH-5um6A:
undetectable		 3v4tH-5um6A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W2T_B_LF7B801_1
(DIPEPTIDYL PEPTIDASE
4)		 5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1
(Schizosaccharomy
ces
pombe) 		5 / 12 GLU A 558
TYR A 544
VAL A 513
ASN A 534
VAL A 433
 None
 1.49A 3w2tB-5um6A:
undetectable		 3w2tB-5um6A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_0
(METHYLTRANSFERASE
NSUN4)		 5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1
(Schizosaccharomy
ces
pombe) 		5 / 12 GLY A 450
ASN A 445
SER A  79
GLY A 864
LEU A 868
 None
 1.00A 4fp9A-5um6A:
3.5		 4fp9A-5um6A:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_0
(METHYLTRANSFERASE
NSUN4)		 5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1
(Schizosaccharomy
ces
pombe) 		5 / 12 GLY A 450
ASN A 445
SER A  79
GLY A 864
LEU A 868
 None
 1.00A 4fp9C-5um6A:
3.5		 4fp9C-5um6A:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_0
(METHYLTRANSFERASE
NSUN4)		 5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1
(Schizosaccharomy
ces
pombe) 		5 / 12 GLY A 450
ASN A 445
SER A  79
GLY A 864
LEU A 868
 None
 1.02A 4fp9D-5um6A:
3.5		 4fp9D-5um6A:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_0
(METHYLTRANSFERASE
NSUN4)		 5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1
(Schizosaccharomy
ces
pombe) 		5 / 12 GLY A 450
ASN A 445
SER A  79
GLY A 864
LEU A 868
 None
 1.00A 4fp9F-5um6A:
5.1		 4fp9F-5um6A:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_0
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1
(Schizosaccharomy
ces
pombe) 		5 / 12 GLY A 450
ASN A 445
SER A  79
GLY A 864
LEU A 868
 None
 1.02A 4fzvA-5um6A:
3.5		 4fzvA-5um6A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1
(Schizosaccharomy
ces
pombe) 		5 / 12 VAL A 127
VAL A  50
ALA A 372
LEU A  58
VAL A  64
 None
 1.08A 4ib4A-5um6A:
undetectable		 4ib4A-5um6A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K36_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1
(Schizosaccharomy
ces
pombe) 		5 / 12 TYR A  81
SER A 358
LEU A  48
VAL A  50
LEU A  83
 None
 1.38A 4k36A-5um6A:
undetectable		 4k36A-5um6A:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K38_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME
KP18CYS PEPTIDE)		 5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1
(Schizosaccharomy
ces
pombe) 		5 / 12 TYR A  81
SER A 358
LEU A  48
VAL A  50
LEU A  83
 None
 1.42A 4k38A-5um6A:
undetectable
4k38D-5um6A:
undetectable		 4k38A-5um6A:
16.87
4k38D-5um6A:
1.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1
(Schizosaccharomy
ces
pombe) 		5 / 12 VAL A 127
VAL A  50
ALA A 372
LEU A  58
VAL A  64
 None
 1.09A 4nc3A-5um6A:
undetectable		 4nc3A-5um6A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_1
(ANDROGEN RECEPTOR)		 5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1
(Schizosaccharomy
ces
pombe) 		5 / 12 LEU A  48
GLY A  49
ARG A 156
THR A  96
VAL A 111
 None
 1.30A 4okwA-5um6A:
undetectable		 4okwA-5um6A:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_1
(ANDROGEN RECEPTOR)		 5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1
(Schizosaccharomy
ces
pombe) 		5 / 12 LEU A  48
GLY A  49
ARG A 156
THR A  96
VAL A 111
 None
 1.29A 4okxA-5um6A:
undetectable		 4okxA-5um6A:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1
(Schizosaccharomy
ces
pombe) 		5 / 12 LEU A  48
GLU A 345
PHE A 159
GLY A 160
LEU A 868
 None
 1.18A 4retA-5um6A:
4.0		 4retA-5um6A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1
(Schizosaccharomy
ces
pombe) 		4 / 7 ILE A 901
PRO A 904
ILE A 916
ASP A 914
 None
 0.89A 4w5oA-5um6A:
2.1		 4w5oA-5um6A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1
(Schizosaccharomy
ces
pombe) 		4 / 7 ILE A 901
PRO A 904
ILE A 916
ASP A 914
 None
 0.90A 4z4eA-5um6A:
2.8		 4z4eA-5um6A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1
(Schizosaccharomy
ces
pombe) 		4 / 7 ILE A 901
PRO A 904
ILE A 916
ASP A 914
 None
 0.89A 4z4gA-5um6A:
4.1		 4z4gA-5um6A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CFT_A_51GA204_1
(AMINOGLYCOSIDE
NUCLEOTIDYLTRANSFERA
SE (2')-IA)		 5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1
(Schizosaccharomy
ces
pombe) 		5 / 9 ASP A 339
TYR A 291
LEU A 389
ILE A 293
TYR A 277
 None
 1.42A 5cftA-5um6A:
1.9		 5cftA-5um6A:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1
(Schizosaccharomy
ces
pombe) 		4 / 6 PHE A 724
SER A 730
ALA A 729
HIS A 818
 None
 0.84A 5dzkB-5um6A:
undetectable
5dzkP-5um6A:
undetectable		 5dzkB-5um6A:
11.46
5dzkP-5um6A:
0.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1
(Schizosaccharomy
ces
pombe) 		4 / 7 PHE A 724
SER A 730
ALA A 729
HIS A 818
 None
 0.83A 5dzkD-5um6A:
undetectable
5dzkR-5um6A:
undetectable		 5dzkD-5um6A:
11.46
5dzkR-5um6A:
0.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_U_BEZU801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1
(Schizosaccharomy
ces
pombe) 		4 / 6 PHE A 724
SER A 730
ALA A 729
HIS A 818
 None
 0.84A 5dzkg-5um6A:
undetectable
5dzku-5um6A:
undetectable		 5dzkg-5um6A:
11.46
5dzku-5um6A:
0.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ENT_C_MIYC901_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB)		 5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1
(Schizosaccharomy
ces
pombe) 		5 / 9 GLN A 673
PHE A 617
ASN A 623
ILE A 621
ALA A 808
 None
 1.35A 5entC-5um6A:
undetectable		 5entC-5um6A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KLA_A_ACTA1505_0
(MATERNAL PROTEIN
PUMILIO)		 5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1
(Schizosaccharomy
ces
pombe) 		3 / 3 HIS A 819
LYS A 812
PHE A 810
 None
 1.50A 5klaA-5um6A:
undetectable		 5klaA-5um6A:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_C_ROCC101_2
(PROTEASE PR5-SQV)		 5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1
(Schizosaccharomy
ces
pombe) 		5 / 9 LEU A 805
ASN A 735
GLY A 615
VAL A 624
ILE A 621
 None
 1.07A 5kr2D-5um6A:
undetectable		 5kr2D-5um6A:
7.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_J_Z80J401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1
(Schizosaccharomy
ces
pombe) 		5 / 12 ILE A 151
ILE A 162
VAL A 127
THR A 129
GLU A 130
 None
 1.17A 5lg3J-5um6A:
undetectable		 5lg3J-5um6A:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA406_0
(THIOREDOXIN
REDUCTASE)		 5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1
(Schizosaccharomy
ces
pombe) 		3 / 3 HIS A 305
SER A 308
ARG A 311
 None
 1.01A 5u63A-5um6A:
6.3		 5u63A-5um6A:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B1E_B_LF7B801_1
(DIPEPTIDYL PEPTIDASE
4)		 5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1
(Schizosaccharomy
ces
pombe) 		5 / 12 GLU A 558
TYR A 544
VAL A 513
ASN A 534
VAL A 433
 None
 1.49A 6b1eB-5um6A:
undetectable		 6b1eB-5um6A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3A_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1
(Schizosaccharomy
ces
pombe) 		5 / 12 PHE A 478
MET A 442
GLY A 439
GLY A 434
ASN A 534
 None
 1.13A 6b3aA-5um6A:
5.1		 6b3aA-5um6A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3B_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1
(Schizosaccharomy
ces
pombe) 		5 / 12 PHE A 478
MET A 442
GLY A 439
GLY A 434
ASN A 534
 None
 1.14A 6b3bA-5um6A:
5.2		 6b3bA-5um6A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_B_REAB601_1
(RETINOIC ACID
RECEPTOR)		 5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1
(Schizosaccharomy
ces
pombe) 		5 / 10 ARG A 547
VAL A 545
PHE A 526
GLY A 514
GLY A 434
 None
 1.21A 6eu9B-5um6A:
undetectable		 6eu9B-5um6A:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_D_FK5D201_0
(PEPTIDYLPROLYL
ISOMERASE)		 5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1
(Schizosaccharomy
ces
pombe) 		4 / 4 ASP A 611
ILE A 592
PRO A 591
LEU A 595
 None
 1.39A 6mkeA-5um6A:
undetectable		 6mkeA-5um6A:
5.56