SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5um8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 5um8 GLYCOPROTEIN GP120
(Human
immunodeficiency
virus
1) 		5 / 12 ILE G 215
ALA G  55
LEU G  52
LEU G 483
ILE G 251
 None
 0.92A 1dhiA-5um8G:
undetectable		 1dhiA-5um8G:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHJ_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 5um8 GLYCOPROTEIN GP120
(Human
immunodeficiency
virus
1) 		5 / 12 ILE G 215
ALA G  55
LEU G  52
LEU G 483
ILE G 251
 None
 0.92A 1dhjA-5um8G:
undetectable		 1dhjA-5um8G:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRB_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 5um8 GLYCOPROTEIN GP120
(Human
immunodeficiency
virus
1) 		5 / 12 ILE G 215
ALA G  55
LEU G  52
LEU G 483
ILE G 251
 None
 0.95A 1drbA-5um8G:
undetectable		 1drbA-5um8G:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRB_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 5um8 GLYCOPROTEIN GP120
(Human
immunodeficiency
virus
1) 		5 / 12 ILE G 215
ALA G  55
LEU G  52
LEU G 483
ILE G 251
 None
 0.96A 1drbB-5um8G:
undetectable		 1drbB-5um8G:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 5um8 GLYCOPROTEIN GP120
(Human
immunodeficiency
virus
1) 		5 / 12 ILE G 215
ALA G  55
LEU G  52
LEU G 483
ILE G 251
 None
 0.90A 1ra3A-5um8G:
undetectable		 1ra3A-5um8G:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB3_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 5um8 GLYCOPROTEIN GP120
(Human
immunodeficiency
virus
1) 		5 / 12 ILE G 215
ALA G  55
LEU G  52
LEU G 483
ILE G 251
 None
 0.91A 1rb3B-5um8G:
undetectable		 1rb3B-5um8G:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 5um8 GLYCOPROTEIN GP120
(Human
immunodeficiency
virus
1) 		5 / 12 ILE G 215
ALA G  55
LEU G  52
LEU G 483
ILE G 251
 None
 0.95A 1rd7B-5um8G:
undetectable		 1rd7B-5um8G:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D0K_B_FOLB2161_0
(DIHYDROFOLATE
REDUCTASE)		 5um8 GLYCOPROTEIN GP120
(Human
immunodeficiency
virus
1) 		5 / 12 ILE G 215
ALA G  55
LEU G  52
LEU G 483
ILE G 251
 None
 0.93A 2d0kB-5um8G:
undetectable		 2d0kB-5um8G:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5um8 GLYCOPROTEIN GP120
(Human
immunodeficiency
virus
1) 		4 / 6 ALA G 329
TYR G 177
ILE G 443
ILE G 420
 None
 1.14A 2dcfA-5um8G:
undetectable		 2dcfA-5um8G:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 5um8 GLYCOPROTEIN GP120
(Human
immunodeficiency
virus
1) 		5 / 12 ILE G 215
ALA G  55
LEU G  52
LEU G 483
ILE G 251
 None
 0.93A 2drcA-5um8G:
undetectable		 2drcA-5um8G:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 5um8 GLYCOPROTEIN GP120
(Human
immunodeficiency
virus
1) 		5 / 12 ILE G 215
ALA G  55
LEU G  52
LEU G 483
ILE G 251
 None
 0.92A 2drcB-5um8G:
undetectable		 2drcB-5um8G:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_D_ASDD1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 5um8 GLYCOPROTEIN GP120
(Human
immunodeficiency
virus
1) 		5 / 9 LEU G 122
LEU G 193
ALA G 161
ALA G 174
PHE G 176
 None
 1.16A 2vcvD-5um8G:
undetectable		 2vcvD-5um8G:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_E_ASDE1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 5um8 GLYCOPROTEIN GP120
(Human
immunodeficiency
virus
1) 		5 / 9 LEU G 122
LEU G 193
ALA G 161
ALA G 174
PHE G 176
 None
 1.10A 2vcvE-5um8G:
undetectable		 2vcvE-5um8G:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_I_ASDI1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 5um8 GLYCOPROTEIN GP120
(Human
immunodeficiency
virus
1) 		5 / 9 LEU G 122
LEU G 193
ALA G 161
ALA G 174
PHE G 176
 None
 1.05A 2vcvI-5um8G:
undetectable		 2vcvI-5um8G:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM7_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5um8 GLYCOPROTEIN GP120
(Human
immunodeficiency
virus
1) 		4 / 7 ALA G 329
TYR G 177
ILE G 443
ILE G 420
 None
 1.14A 2zm7A-5um8G:
undetectable		 2zm7A-5um8G:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA2_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 5um8 GLYCOPROTEIN GP120
(Human
immunodeficiency
virus
1) 		3 / 3 LYS G 487
LYS G  46
VAL G 489
 None
 1.02A 3brfA-5um8G:
undetectable		 3brfA-5um8G:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFL_A_5CHA693_1
(LACTOTRANSFERRIN)		 5um8 GLYCOPROTEIN GP120
GLYCOPROTEIN GP41
(Human
immunodeficiency
virus
1) 		4 / 4 THR G  37
VAL G  42
GLY B 531
THR B 529
 None
 1.10A 3cflA-5um8G:
undetectable		 3cflA-5um8G:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 5um8 GLYCOPROTEIN GP120
(Human
immunodeficiency
virus
1) 		5 / 12 ILE G 215
ALA G  55
LEU G  52
LEU G 483
ILE G 251
 None
 0.93A 3drcA-5um8G:
undetectable		 3drcA-5um8G:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 5um8 GLYCOPROTEIN GP120
(Human
immunodeficiency
virus
1) 		5 / 12 ILE G 215
ALA G  55
LEU G  52
LEU G 483
ILE G 251
 None
 0.92A 3drcB-5um8G:
undetectable		 3drcB-5um8G:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FW1_A_STIA233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5um8 GLYCOPROTEIN GP120
(Human
immunodeficiency
virus
1) 		5 / 10 GLY G 473
GLY G 472
THR G 257
ASN G 478
ILE G 371
 None
 1.46A 3fw1A-5um8G:
undetectable		 3fw1A-5um8G:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 5um8 GLYCOPROTEIN GP120
(Human
immunodeficiency
virus
1) 		5 / 12 LEU G 342
LEU G 454
THR G 394
ILE G 359
THR G 387
 None
None
NAG  G 725 (-3.6A)
None
None
 1.11A 3hj3A-5um8G:
undetectable		 3hj3A-5um8G:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5um8 GLYCOPROTEIN GP120
(Human
immunodeficiency
virus
1) 		5 / 12 LEU G 454
LEU G 277
PHE G 361
ILE G 359
GLY G 346
 None
 1.13A 3kk6A-5um8G:
undetectable		 3kk6A-5um8G:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5um8 GLYCOPROTEIN GP120
(Human
immunodeficiency
virus
1) 		5 / 12 LEU G 454
LEU G 277
PHE G 361
ILE G 359
GLY G 346
 None
 1.12A 3kk6B-5um8G:
undetectable		 3kk6B-5um8G:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGQ_A_AB1A200_1
(FIV PROTEASE)		 5um8 GLYCOPROTEIN GP120
(Human
immunodeficiency
virus
1) 		5 / 10 LEU G 259
ILE G 284
VAL G 286
GLY G 346
LEU G 452
 None
 1.00A 3ogqA-5um8G:
undetectable		 3ogqA-5um8G:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_C_DSFC320_1
(GLR4197 PROTEIN)		 5um8 GLYCOPROTEIN GP120
(Human
immunodeficiency
virus
1) 		4 / 8 ILE G 333
ILE G 414
VAL G 292
ILE G 339
 None
 0.86A 3p4wC-5um8G:
undetectable		 3p4wC-5um8G:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_A_GLYA510_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5um8 GLYCOPROTEIN GP120
(Human
immunodeficiency
virus
1) 		4 / 6 ILE G 443
GLU G 381
ALA G 329
ASN G 300
 None
 1.14A 3pgyA-5um8G:
undetectable
3pgyB-5um8G:
undetectable		 3pgyA-5um8G:
20.47
3pgyB-5um8G:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U88_A_CHDA611_0
(MENIN)		 5um8 GLYCOPROTEIN GP120
(Human
immunodeficiency
virus
1) 		3 / 3 SER G 375
PHE G 382
LYS G 421
 None
 0.81A 3u88A-5um8G:
undetectable		 3u88A-5um8G:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5um8 GLYCOPROTEIN GP120
(Human
immunodeficiency
virus
1) 		4 / 6 GLY G 471
GLY G 472
ASN G 477
ILE G 371
 None
 0.79A 4fglD-5um8G:
undetectable		 4fglD-5um8G:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5um8 GLYCOPROTEIN GP120
(Human
immunodeficiency
virus
1) 		5 / 12 ILE G 215
ALA G  55
LEU G  52
LEU G 483
ILE G 251
 None
 0.93A 4i13A-5um8G:
undetectable		 4i13A-5um8G:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JVL_A_ESTA702_1
(ESTROGEN
SULFOTRANSFERASE)		 5um8 GLYCOPROTEIN GP120
(Human
immunodeficiency
virus
1) 		4 / 9 PHE G 376
HIS G 374
ILE G 424
MET G 426
 None
 1.37A 4jvlA-5um8G:
undetectable		 4jvlA-5um8G:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K39_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 5um8 GLYCOPROTEIN GP120
(Human
immunodeficiency
virus
1) 		5 / 12 PHE G 391
ASN G 332
VAL G 292
ILE G 449
LEU G 452
 None
NAG  G 728 (-1.8A)
None
None
None
 1.29A 4k39A-5um8G:
undetectable		 4k39A-5um8G:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA303_1
(CHITOSANASE)		 5um8 GLYCOPROTEIN GP41
(Human
immunodeficiency
virus
1) 		4 / 6 ILE B 583
ARG B 579
GLY B 547
VAL B 549
 None
 1.07A 4oltA-5um8B:
undetectable		 4oltA-5um8B:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB303_1
(CHITOSANASE)		 5um8 GLYCOPROTEIN GP41
(Human
immunodeficiency
virus
1) 		4 / 6 ILE B 583
ARG B 579
GLY B 547
VAL B 549
 None
 1.03A 4oltB-5um8B:
undetectable		 4oltB-5um8B:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P66_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 5um8 GLYCOPROTEIN GP120
(Human
immunodeficiency
virus
1) 		5 / 11 ILE G 215
ALA G  55
LEU G  52
LEU G 483
ILE G 251
 None
 0.87A 4p66A-5um8G:
undetectable		 4p66A-5um8G:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5um8 GLYCOPROTEIN GP120
(Human
immunodeficiency
virus
1) 		5 / 12 ILE G 215
ALA G  55
LEU G  52
LEU G 483
ILE G 251
 None
 0.95A 4x5iA-5um8G:
undetectable		 4x5iA-5um8G:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5um8 GLYCOPROTEIN GP120
(Human
immunodeficiency
virus
1) 		3 / 3 ALA G 224
TYR G 223
PRO G 493
 None
 0.72A 4zdyA-5um8G:
undetectable		 4zdyA-5um8G:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_A_PAUA302_0
(TYPE III
PANTOTHENATE KINASE)		 5um8 GLYCOPROTEIN GP41
GLYCOPROTEIN GP120
(Human
immunodeficiency
virus
1;
Human
immunodeficiency
virus
1) 		5 / 12 LEU G 494
GLY G 495
ASP B 632
THR B 639
ILE B 642
 None
 1.20A 5b8hA-5um8G:
undetectable
5b8hB-5um8G:
undetectable		 5b8hA-5um8G:
16.26
5b8hB-5um8G:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 5um8 GLYCOPROTEIN GP41
GLYCOPROTEIN GP120
(Human
immunodeficiency
virus
1;
Human
immunodeficiency
virus
1) 		5 / 12 LEU G 494
GLY G 495
ASP B 632
THR B 639
ILE B 642
 None
 1.20A 5b8hA-5um8G:
undetectable
5b8hB-5um8G:
undetectable		 5b8hA-5um8G:
16.26
5b8hB-5um8G:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA610_0
(SERUM ALBUMIN)		 5um8 GLYCOPROTEIN GP120
(Human
immunodeficiency
virus
1) 		3 / 3 TYR G 486
LYS G 485
LYS G 227
 None
 1.34A 5dbyA-5um8G:
undetectable		 5dbyA-5um8G:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5um8 GLYCOPROTEIN GP120
(Human
immunodeficiency
virus
1) 		4 / 5 GLU G  49
THR G  50
GLU G 490
LEU G 226
 None
 1.11A 5hm8A-5um8G:
undetectable		 5hm8A-5um8G:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_B_ADNB501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5um8 GLYCOPROTEIN GP120
(Human
immunodeficiency
virus
1) 		4 / 5 GLU G  49
THR G  50
GLU G 490
LEU G 226
 None
 1.10A 5hm8B-5um8G:
undetectable		 5hm8B-5um8G:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_C_ADNC501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5um8 GLYCOPROTEIN GP120
(Human
immunodeficiency
virus
1) 		4 / 5 GLU G  49
THR G  50
GLU G 490
LEU G 226
 None
 1.11A 5hm8C-5um8G:
undetectable		 5hm8C-5um8G:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_D_ADND501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5um8 GLYCOPROTEIN GP120
(Human
immunodeficiency
virus
1) 		4 / 5 GLU G  49
THR G  50
GLU G 490
LEU G 226
 None
 1.11A 5hm8D-5um8G:
undetectable		 5hm8D-5um8G:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_E_ADNE501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5um8 GLYCOPROTEIN GP120
(Human
immunodeficiency
virus
1) 		4 / 5 GLU G  49
THR G  50
GLU G 490
LEU G 226
 None
 1.10A 5hm8E-5um8G:
undetectable		 5hm8E-5um8G:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_F_ADNF501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5um8 GLYCOPROTEIN GP120
(Human
immunodeficiency
virus
1) 		4 / 5 GLU G  49
THR G  50
GLU G 490
LEU G 226
 None
 1.11A 5hm8F-5um8G:
undetectable		 5hm8F-5um8G:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_G_ADNG501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5um8 GLYCOPROTEIN GP120
(Human
immunodeficiency
virus
1) 		4 / 5 GLU G  49
THR G  50
GLU G 490
LEU G 226
 None
 1.04A 5hm8G-5um8G:
undetectable		 5hm8G-5um8G:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_H_ADNH501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5um8 GLYCOPROTEIN GP120
(Human
immunodeficiency
virus
1) 		4 / 5 GLU G  49
THR G  50
GLU G 490
LEU G 226
 None
 1.11A 5hm8H-5um8G:
undetectable		 5hm8H-5um8G:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5um8 GLYCOPROTEIN GP120
(Human
immunodeficiency
virus
1) 		3 / 3 VAL G 254
SER G 481
MET G 100
 None
 0.92A 5ikqA-5um8G:
undetectable		 5ikqA-5um8G:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_A_CCSA14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 5um8 GLYCOPROTEIN GP120
(Human
immunodeficiency
virus
1) 		4 / 6 PHE G 468
LEU G 452
ARG G 469
GLY G 471
 None
 0.80A 5o4yA-5um8G:
undetectable		 5o4yA-5um8G:
1.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_F_CCSF14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 5um8 GLYCOPROTEIN GP120
(Human
immunodeficiency
virus
1) 		4 / 6 PHE G 468
LEU G 452
ARG G 469
GLY G 471
 None
 1.11A 5o4yF-5um8G:
undetectable		 5o4yF-5um8G:
1.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_1
(REGULATORY PROTEIN
TETR)		 5um8 GLYCOPROTEIN GP41
(Human
immunodeficiency
virus
1) 		4 / 7 GLY B 594
TRP B 596
ASP B 589
TYR B 586
 None
 1.25A 5vlmG-5um8B:
undetectable		 5vlmG-5um8B:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YSI_A_NCAA1001_0
(UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA)		 5um8 GLYCOPROTEIN GP120
(Human
immunodeficiency
virus
1) 		4 / 6 ARG G 456
GLY G 458
THR G 465
VAL G 460
 None
None
NAG  G 725 (-3.1A)
None
 1.09A 5ysiA-5um8G:
undetectable		 5ysiA-5um8G:
15.91