SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ume'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_F_BEZF5023_0
(CES1 PROTEIN)		 5ume 5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE
(Haemophilus
influenzae) 		4 / 6 SER A  55
LEU A 115
ILE A 179
HIS A 271
 None
FAD  A 300 (-3.9A)
FAD  A 300 (-4.0A)
None
 0.97A 1yajF-5umeA:
undetectable		 1yajF-5umeA:
20.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3APT_B_ACTB311_0
(METHYLENETETRAHYDROF
OLATE REDUCTASE)		 5ume 5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE
(Haemophilus
influenzae) 		6 / 9 GLU A  26
HIS A  86
ALA A 148
ILE A 179
HIS A 271
TYR A 273
 ACY  A 302 (-2.8A)
FAD  A 300 (-3.8A)
FAD  A 300 (-3.4A)
FAD  A 300 (-4.0A)
None
ACY  A 302 ( 4.0A)
 0.53A 3aptB-5umeA:
29.1		 3aptB-5umeA:
38.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FSU_A_C2FA995_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 5ume 5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE
(Haemophilus
influenzae) 		7 / 12 THR A  57
GLN A 181
LEU A 210
ASN A 214
THR A 225
TYR A 273
ARG A 277
 FAD  A 300 (-4.4A)
ACY  A 302 ( 3.9A)
None
None
None
ACY  A 302 ( 4.0A)
None
 0.69A 3fsuA-5umeA:
42.9		 3fsuA-5umeA:
72.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FSU_A_C2FA995_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 5ume 5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE
(Haemophilus
influenzae) 		7 / 12 THR A  57
GLN A 181
LEU A 210
ASN A 214
THR A 225
TYR A 273
LEU A 275
 FAD  A 300 (-4.4A)
ACY  A 302 ( 3.9A)
None
None
None
ACY  A 302 ( 4.0A)
None
 0.46A 3fsuA-5umeA:
42.9		 3fsuA-5umeA:
72.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FSU_E_C2FE995_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 5ume 5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE
(Haemophilus
influenzae) 		5 / 11 THR A  57
GLN A 181
THR A 225
TYR A 273
LEU A 275
 FAD  A 300 (-4.4A)
ACY  A 302 ( 3.9A)
None
ACY  A 302 ( 4.0A)
None
 0.42A 3fsuE-5umeA:
40.7		 3fsuE-5umeA:
72.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB315_0
(UNCHARACTERIZED
PROTEIN)		 5ume 5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE
(Haemophilus
influenzae) 		5 / 12 THR A  57
ILE A  71
THR A  68
VAL A  54
LYS A  52
 FAD  A 300 (-4.4A)
None
None
None
None
 1.30A 3ijdB-5umeA:
12.6		 3ijdB-5umeA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5ume 5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE
(Haemophilus
influenzae) 		4 / 7 VAL A  23
VAL A 267
ILE A 209
ARG A 291
 None
 1.25A 3ms9B-5umeA:
undetectable		 3ms9B-5umeA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKA_A_SAMA400_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H)		 5ume 5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE
(Haemophilus
influenzae) 		5 / 12 THR A 274
GLY A 208
HIS A 271
ARG A 277
GLN A 217
 None
 0.99A 3tkaA-5umeA:
undetectable		 3tkaA-5umeA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5ume 5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE
(Haemophilus
influenzae) 		5 / 10 TYR A 189
PHE A 183
LEU A 288
VAL A  23
PHE A 272
 None
 1.26A 3u9fE-5umeA:
undetectable		 3u9fE-5umeA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_K_CLMK221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5ume 5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE
(Haemophilus
influenzae) 		5 / 10 TYR A 189
PHE A 183
LEU A 288
VAL A  23
PHE A 272
 None
 1.24A 3u9fK-5umeA:
undetectable		 3u9fK-5umeA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4II8_A_010A210_0
(LYSOZYME C)		 5ume 5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE
(Haemophilus
influenzae) 		4 / 7 GLU A  36
ASN A 276
ILE A  43
TRP A  40
 None
 1.17A 4ii8A-5umeA:
undetectable		 4ii8A-5umeA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_CQAB303_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5ume 5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE
(Haemophilus
influenzae) 		4 / 8 GLY A 266
ILE A 261
GLU A   6
LEU A  10
 None
 0.85A 4mwzB-5umeA:
undetectable		 4mwzB-5umeA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5ume 5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE
(Haemophilus
influenzae) 		4 / 5 ILE A 261
LEU A 262
ASP A 185
VAL A 212
 None
 1.03A 4nkxB-5umeA:
undetectable		 4nkxB-5umeA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6V_E_RBFE201_1
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E)		 5ume 5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE
(Haemophilus
influenzae) 		4 / 5 HIS A  86
VAL A  56
GLU A  26
VAL A 113
 FAD  A 300 (-3.8A)
None
ACY  A 302 (-2.8A)
None
 0.99A 4p6vB-5umeA:
undetectable
4p6vE-5umeA:
undetectable		 4p6vB-5umeA:
20.67
4p6vE-5umeA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCU_A_SAMA603_0
(CYSTATHIONINE
BETA-SYNTHASE)		 5ume 5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE
(Haemophilus
influenzae) 		4 / 7 PRO A  29
THR A  88
ILE A  90
ASP A  91
 None
FAD  A 300 ( 4.3A)
None
None
 0.99A 4pcuA-5umeA:
2.4		 4pcuA-5umeA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA615_1
(PHIAB6 TAILSPIKE)		 5ume 5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE
(Haemophilus
influenzae) 		3 / 3 TYR A 273
TYR A 150
GLN A 181
 ACY  A 302 ( 4.0A)
FAD  A 300 (-4.3A)
ACY  A 302 ( 3.9A)
 0.93A 5jsdA-5umeA:
undetectable
5jsdB-5umeA:
undetectable		 5jsdA-5umeA:
17.35
5jsdB-5umeA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB606_1
(PHIAB6 TAILSPIKE)		 5ume 5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE
(Haemophilus
influenzae) 		3 / 3 TYR A 273
TYR A 150
GLN A 181
 ACY  A 302 ( 4.0A)
FAD  A 300 (-4.3A)
ACY  A 302 ( 3.9A)
 0.92A 5jsdB-5umeA:
undetectable
5jsdC-5umeA:
undetectable		 5jsdB-5umeA:
17.35
5jsdC-5umeA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA511_1
(PROTON-GATED ION
CHANNEL)		 5ume 5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE
(Haemophilus
influenzae) 		4 / 8 ILE A  71
ALA A  74
ILE A  75
GLU A  78
 None
 0.56A 5mvmA-5umeA:
undetectable
5mvmB-5umeA:
undetectable		 5mvmA-5umeA:
14.39
5mvmB-5umeA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_B_NIZB808_1
(CATALASE-PEROXIDASE)		 5ume 5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE
(Haemophilus
influenzae) 		4 / 8 GLU A  26
GLY A 208
GLN A 181
THR A 180
 ACY  A 302 (-2.8A)
None
ACY  A 302 ( 3.9A)
None
 1.00A 5sxqB-5umeA:
undetectable		 5sxqB-5umeA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_A_NIZA809_1
(CATALASE-PEROXIDASE)		 5ume 5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE
(Haemophilus
influenzae) 		4 / 8 GLU A  26
GLY A 208
GLN A 181
THR A 180
 ACY  A 302 (-2.8A)
None
ACY  A 302 ( 3.9A)
None
 0.99A 5syjA-5umeA:
undetectable		 5syjA-5umeA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA608_0
(ALPHA-AMYLASE)		 5ume 5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE
(Haemophilus
influenzae) 		4 / 6 GLY A 208
THR A 180
GLN A 181
TYR A 273
 None
None
ACY  A 302 ( 3.9A)
ACY  A 302 ( 4.0A)
 1.13A 6ag0A-5umeA:
6.7		 6ag0A-5umeA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC606_0
(ALPHA-AMYLASE)		 5ume 5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE
(Haemophilus
influenzae) 		4 / 6 GLY A 208
THR A 180
GLN A 181
TYR A 273
 None
None
ACY  A 302 ( 3.9A)
ACY  A 302 ( 4.0A)
 1.10A 6ag0C-5umeA:
10.2		 6ag0C-5umeA:
16.96