SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5umf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 5umf RIBULOSE-PHOSPHATE
3-EPIMERASE
(Neisseria
gonorrhoeae) 		5 / 12 ALA A  85
ILE A 175
PHE A  35
LEU A 114
LEU A  68
 None
 1.20A 1eiiA-5umfA:
undetectable		 1eiiA-5umfA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_C_SAMC302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 5umf RIBULOSE-PHOSPHATE
3-EPIMERASE
(Neisseria
gonorrhoeae) 		5 / 12 LEU A 114
GLY A 113
VAL A  66
ILE A 175
LEU A 102
 None
 0.97A 3cjtC-5umfA:
2.5		 3cjtC-5umfA:
26.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 5umf RIBULOSE-PHOSPHATE
3-EPIMERASE
(Neisseria
gonorrhoeae) 		5 / 12 ALA A  28
ILE A 205
ARG A   5
ILE A 188
LEU A 222
 None
 1.07A 3k2hB-5umfA:
undetectable		 3k2hB-5umfA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIH_A_CUA358_0
(PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE)		 5umf RIBULOSE-PHOSPHATE
3-EPIMERASE
(Neisseria
gonorrhoeae) 		3 / 3 HIS A  67
HIS A  91
MET A  69
 ZN  A 301 (-3.3A)
None
None
 0.66A 3mihA-5umfA:
undetectable		 3mihA-5umfA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGZ_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 5umf RIBULOSE-PHOSPHATE
3-EPIMERASE
(Neisseria
gonorrhoeae) 		5 / 10 ILE A 205
ILE A   6
ASP A 180
ILE A 183
SER A  12
 None
None
ZN  A 301 (-3.8A)
None
PO4  A 302 ( 3.9A)
 1.25A 3qgzA-5umfA:
undetectable		 3qgzA-5umfA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B17_A_SAMA1358_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M)		 5umf RIBULOSE-PHOSPHATE
3-EPIMERASE
(Neisseria
gonorrhoeae) 		5 / 12 GLY A 145
GLY A 146
ASP A  36
ASP A  65
VAL A 179
 PO4  A 302 (-3.6A)
PO4  A 302 (-3.7A)
ZN  A 301 (-2.5A)
None
None
 1.04A 4b17A-5umfA:
undetectable		 4b17A-5umfA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA206_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 5umf RIBULOSE-PHOSPHATE
3-EPIMERASE
(Neisseria
gonorrhoeae) 		4 / 4 ALA A 213
ALA A 216
ALA A 217
ALA A 220
 None
 0.13A 4oadA-5umfA:
undetectable		 4oadA-5umfA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCU_A_SAMA603_0
(CYSTATHIONINE
BETA-SYNTHASE)		 5umf RIBULOSE-PHOSPHATE
3-EPIMERASE
(Neisseria
gonorrhoeae) 		4 / 7 PRO A  63
THR A 198
ILE A 177
ASP A 197
 None
 0.81A 4pcuA-5umfA:
2.4		 4pcuA-5umfA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_A_ADNA303_1
(5'/3'-NUCLEOTIDASE
SURE)		 5umf RIBULOSE-PHOSPHATE
3-EPIMERASE
(Neisseria
gonorrhoeae) 		5 / 10 GLY A 113
ALA A  94
ILE A  98
LEU A 114
LEU A 102
 None
 1.20A 4xj7A-5umfA:
undetectable
4xj7B-5umfA:
undetectable		 4xj7A-5umfA:
25.96
4xj7B-5umfA:
25.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_D_ADND303_1
(5'/3'-NUCLEOTIDASE
SURE)		 5umf RIBULOSE-PHOSPHATE
3-EPIMERASE
(Neisseria
gonorrhoeae) 		5 / 10 LEU A 114
LEU A 102
GLY A 113
ALA A  94
ILE A  98
 None
 1.17A 4xj7C-5umfA:
undetectable
4xj7D-5umfA:
undetectable		 4xj7C-5umfA:
25.96
4xj7D-5umfA:
25.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYJ_A_OQRA302_0
(SULFOTRANSFERASE)		 5umf RIBULOSE-PHOSPHATE
3-EPIMERASE
(Neisseria
gonorrhoeae) 		5 / 12 PHE A 199
ILE A 183
LEU A 137
PHE A 149
THR A 153
 None
 1.12A 5byjA-5umfA:
undetectable		 5byjA-5umfA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_A_RBFA502_1
(RIBOFLAVIN LYASE)		 5umf RIBULOSE-PHOSPHATE
3-EPIMERASE
(Neisseria
gonorrhoeae) 		5 / 12 ALA A   7
ALA A 201
GLY A 181
ALA A 176
SER A 139
 None
PO4  A 302 (-4.5A)
PO4  A 302 ( 3.8A)
None
None
 0.87A 5w4zA-5umfA:
6.9		 5w4zA-5umfA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_B_RBFB502_1
(RIBOFLAVIN LYASE)		 5umf RIBULOSE-PHOSPHATE
3-EPIMERASE
(Neisseria
gonorrhoeae) 		5 / 12 ALA A   7
ALA A 201
GLY A 181
ALA A 176
SER A 139
 None
PO4  A 302 (-4.5A)
PO4  A 302 ( 3.8A)
None
None
 0.87A 5w4zB-5umfA:
10.5		 5w4zB-5umfA:
15.32