SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5umg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_1
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 5umg DIHYDROPTEROATE
SYNTHASE
(Klebsiella
pneumoniae) 		4 / 4 THR A 262
LEU A 266
VAL A 269
LEU A 273
 None
 0.57A 1fbmB-5umgA:
undetectable		 1fbmB-5umgA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YCJ_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 5umg DIHYDROPTEROATE
SYNTHASE
(Klebsiella
pneumoniae) 		5 / 12 ASP A  56
ASN A 115
ASP A 185
GLY A 217
SER A 219
 None
 1.16A 2ycjA-5umgA:
21.2		 2ycjA-5umgA:
25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_C_T44C128_1
(5-HYDROXYISOURATE
HYDROLASE)		 5umg DIHYDROPTEROATE
SYNTHASE
(Klebsiella
pneumoniae) 		4 / 6 LEU A   3
LEU A  12
LEU A 184
LEU A 214
 None
 1.10A 3q1eA-5umgA:
undetectable
3q1eC-5umgA:
undetectable		 3q1eA-5umgA:
20.77
3q1eC-5umgA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_C_T44C128_1
(5-HYDROXYISOURATE
HYDROLASE)		 5umg DIHYDROPTEROATE
SYNTHASE
(Klebsiella
pneumoniae) 		4 / 6 LEU A 184
LEU A 214
LEU A   3
LEU A  12
 None
 1.07A 3q1eA-5umgA:
undetectable
3q1eC-5umgA:
undetectable		 3q1eA-5umgA:
20.77
3q1eC-5umgA:
20.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TYE_B_YTZB902_1
(DIHYDROPTEROATE
SYNTHASE)		 5umg DIHYDROPTEROATE
SYNTHASE
(Klebsiella
pneumoniae) 		3 / 3 PHE A 190
LYS A 221
SER A 222
 None
 0.65A 3tyeB-5umgA:
35.9		 3tyeB-5umgA:
40.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TZF_B_08DB280_1
(7,8-DIHYDROPTEROATE
SYNTHASE)		 5umg DIHYDROPTEROATE
SYNTHASE
(Klebsiella
pneumoniae) 		4 / 8 GLY A 189
PHE A 190
LYS A 221
SER A 222
 None
 0.30A 3tzfB-5umgA:
40.4		 3tzfB-5umgA:
76.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_B_C2FB302_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 5umg DIHYDROPTEROATE
SYNTHASE
(Klebsiella
pneumoniae) 		5 / 12 ASP A  56
ASN A 115
ASP A 185
GLY A 217
SER A 219
 None
 0.98A 4djeB-5umgA:
21.1		 4djeB-5umgA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_B_C2FB302_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 5umg DIHYDROPTEROATE
SYNTHASE
(Klebsiella
pneumoniae) 		6 / 12 ASP A  56
ASP A  96
ASN A 115
ASP A 185
GLY A 217
SER A 219
 None
 0.94A 4djeB-5umgA:
21.1		 4djeB-5umgA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_B_C2FB300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 5umg DIHYDROPTEROATE
SYNTHASE
(Klebsiella
pneumoniae) 		5 / 12 ASP A  56
ASP A  96
ASN A 115
GLY A 217
SER A 219
 None
 0.96A 4djfB-5umgA:
16.4		 4djfB-5umgA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_B_MTXB603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 5umg DIHYDROPTEROATE
SYNTHASE
(Klebsiella
pneumoniae) 		5 / 12 ALA A 130
LEU A 120
LYS A 179
ILE A 113
LEU A   3
 None
 1.10A 4ky8B-5umgA:
undetectable		 4ky8B-5umgA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_A_MTXA604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5umg DIHYDROPTEROATE
SYNTHASE
(Klebsiella
pneumoniae) 		5 / 12 ALA A 130
LEU A 120
LYS A 179
ILE A 113
LEU A   3
 None
 1.14A 4q0dA-5umgA:
undetectable		 4q0dA-5umgA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_B_MTXB604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5umg DIHYDROPTEROATE
SYNTHASE
(Klebsiella
pneumoniae) 		5 / 12 ALA A 130
LEU A 120
LYS A 179
ILE A 113
LEU A   3
 None
 1.14A 4q0dB-5umgA:
undetectable		 4q0dB-5umgA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_E_MTXE604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5umg DIHYDROPTEROATE
SYNTHASE
(Klebsiella
pneumoniae) 		5 / 12 ALA A 130
LEU A 120
LYS A 179
ILE A 113
LEU A   3
 None
 1.14A 4q0dE-5umgA:
undetectable		 4q0dE-5umgA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWZ_B_BEZB301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5umg DIHYDROPTEROATE
SYNTHASE
(Klebsiella
pneumoniae) 		3 / 3 MET A 223
GLN A 226
ARG A 235
 None
 1.00A 5ewzB-5umgA:
undetectable		 5ewzB-5umgA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5umg DIHYDROPTEROATE
SYNTHASE
(Klebsiella
pneumoniae) 		3 / 3 ASP A  96
ASN A 115
ASP A 185
 None
 0.69A 5vopA-5umgA:
8.5		 5vopA-5umgA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5umg DIHYDROPTEROATE
SYNTHASE
(Klebsiella
pneumoniae) 		3 / 3 ASP A  96
ASN A 115
ASP A 185
 None
 0.71A 5vopB-5umgA:
8.3		 5vopB-5umgA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXL_B_SAMB401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)		 5umg DIHYDROPTEROATE
SYNTHASE
(Klebsiella
pneumoniae) 		5 / 12 TYR A 281
LEU A 204
GLY A 205
HIS A 208
ARG A 280
 None
 1.35A 6bxlB-5umgA:
undetectable		 6bxlB-5umgA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_2
(-)		 5umg DIHYDROPTEROATE
SYNTHASE
(Klebsiella
pneumoniae) 		5 / 12 ASN A  22
ARG A 118
GLU A 122
GLU A  74
GLY A  59
 None
 1.43A 6gnfC-5umgA:
undetectable		 6gnfC-5umgA:
20.26