SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5umh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5umh CATECHOL
1,2-DIOXYGENASE
(Burkholderia
multivorans) 		3 / 3 GLU A 106
TYR A 110
PHE A 228
 None
 0.75A 1eqbB-5umhA:
undetectable		 1eqbB-5umhA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_FFOB2293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5umh CATECHOL
1,2-DIOXYGENASE
(Burkholderia
multivorans) 		3 / 3 GLU A 106
TYR A 110
PHE A 228
 None
 0.75A 1eqbA-5umhA:
undetectable		 1eqbA-5umhA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5umh CATECHOL
1,2-DIOXYGENASE
(Burkholderia
multivorans) 		3 / 3 GLU A 106
TYR A 110
PHE A 228
 None
 0.75A 1eqbD-5umhA:
undetectable		 1eqbD-5umhA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_FFOD4293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5umh CATECHOL
1,2-DIOXYGENASE
(Burkholderia
multivorans) 		3 / 3 GLU A 106
TYR A 110
PHE A 228
 None
 0.75A 1eqbC-5umhA:
undetectable		 1eqbC-5umhA:
22.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1S9A_A_BEZA306_0
(CHLOROCATECHOL
1,2-DIOXYGENASE)		 5umh CATECHOL
1,2-DIOXYGENASE
(Burkholderia
multivorans) 		9 / 11 LEU A  73
ILE A 105
GLY A 107
PRO A 108
TYR A 164
TYR A 200
ARG A 221
HIS A 224
HIS A 226
 None
None
EDO  A 402 (-3.6A)
EDO  A 402 (-4.4A)
ZN  A 401 ( 4.2A)
ZN  A 401 ( 4.7A)
EDO  A 402 (-3.4A)
ZN  A 401 ( 3.3A)
ZN  A 401 ( 3.2A)
 0.45A 1s9aA-5umhA:
27.9		 1s9aA-5umhA:
30.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1S9A_B_BEZB307_0
(CHLOROCATECHOL
1,2-DIOXYGENASE)		 5umh CATECHOL
1,2-DIOXYGENASE
(Burkholderia
multivorans) 		10 / 12 LEU A  73
ILE A 105
GLY A 107
PRO A 108
TYR A 164
TYR A 200
ARG A 221
HIS A 224
HIS A 226
GLN A 240
 None
None
EDO  A 402 (-3.6A)
EDO  A 402 (-4.4A)
ZN  A 401 ( 4.2A)
ZN  A 401 ( 4.7A)
EDO  A 402 (-3.4A)
ZN  A 401 ( 3.3A)
ZN  A 401 ( 3.2A)
None
 0.71A 1s9aB-5umhA:
27.5		 1s9aB-5umhA:
30.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TMX_A_BEZA881_0
(HYDROXYQUINOL
1,2-DIOXYGENASE)		 5umh CATECHOL
1,2-DIOXYGENASE
(Burkholderia
multivorans) 		7 / 11 GLY A 107
PRO A 108
TYR A 164
TYR A 200
ARG A 221
HIS A 224
HIS A 226
 EDO  A 402 (-3.6A)
EDO  A 402 (-4.4A)
ZN  A 401 ( 4.2A)
ZN  A 401 ( 4.7A)
EDO  A 402 (-3.4A)
ZN  A 401 ( 3.3A)
ZN  A 401 ( 3.2A)
 0.39A 1tmxA-5umhA:
27.5		 1tmxA-5umhA:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TMX_A_BEZA881_0
(HYDROXYQUINOL
1,2-DIOXYGENASE)		 5umh CATECHOL
1,2-DIOXYGENASE
(Burkholderia
multivorans) 		5 / 11 LEU A  73
GLY A 107
ARG A 221
HIS A 224
HIS A 226
 None
EDO  A 402 (-3.6A)
EDO  A 402 (-3.4A)
ZN  A 401 ( 3.3A)
ZN  A 401 ( 3.2A)
 0.93A 1tmxA-5umhA:
27.5		 1tmxA-5umhA:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TMX_B_BEZB882_0
(HYDROXYQUINOL
1,2-DIOXYGENASE)		 5umh CATECHOL
1,2-DIOXYGENASE
(Burkholderia
multivorans) 		7 / 12 GLY A 107
PRO A 108
TYR A 164
TYR A 200
ARG A 221
HIS A 224
HIS A 226
 EDO  A 402 (-3.6A)
EDO  A 402 (-4.4A)
ZN  A 401 ( 4.2A)
ZN  A 401 ( 4.7A)
EDO  A 402 (-3.4A)
ZN  A 401 ( 3.3A)
ZN  A 401 ( 3.2A)
 0.38A 1tmxB-5umhA:
27.0		 1tmxB-5umhA:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TMX_B_BEZB882_0
(HYDROXYQUINOL
1,2-DIOXYGENASE)		 5umh CATECHOL
1,2-DIOXYGENASE
(Burkholderia
multivorans) 		5 / 12 GLY A 107
TYR A 200
ARG A 221
HIS A 224
HIS A 226
 EDO  A 402 (-3.6A)
ZN  A 401 ( 4.7A)
EDO  A 402 (-3.4A)
ZN  A 401 ( 3.3A)
ZN  A 401 ( 3.2A)
 1.42A 1tmxB-5umhA:
27.0		 1tmxB-5umhA:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XQL_B_4AXB505_1
(ALANINE RACEMASE)		 5umh CATECHOL
1,2-DIOXYGENASE
(Burkholderia
multivorans) 		4 / 8 TYR A 164
TYR A 200
PHE A 253
CYH A 202
 ZN  A 401 ( 4.2A)
ZN  A 401 ( 4.7A)
None
None
 1.31A 1xqlA-5umhA:
undetectable
1xqlB-5umhA:
undetectable		 1xqlA-5umhA:
22.57
1xqlB-5umhA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 5umh CATECHOL
1,2-DIOXYGENASE
(Burkholderia
multivorans) 		5 / 12 PHE A 228
ALA A 254
PRO A 108
GLY A  77
TYR A 110
 None
None
EDO  A 402 (-4.4A)
None
None
 1.15A 2igtB-5umhA:
undetectable		 2igtB-5umhA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 5umh CATECHOL
1,2-DIOXYGENASE
(Burkholderia
multivorans) 		5 / 12 PHE A 228
ALA A 254
PRO A 108
GLY A  77
TYR A 110
 None
None
EDO  A 402 (-4.4A)
None
None
 1.12A 2igtC-5umhA:
undetectable		 2igtC-5umhA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_SAMA201_0
(UPF0066 PROTEIN
AF_0241)		 5umh CATECHOL
1,2-DIOXYGENASE
(Burkholderia
multivorans) 		5 / 12 ALA A  95
GLN A 300
PRO A 292
GLY A 100
ASP A  92
 None
 1.14A 2nv4A-5umhA:
undetectable		 2nv4A-5umhA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 5umh CATECHOL
1,2-DIOXYGENASE
(Burkholderia
multivorans) 		5 / 12 THR A 239
THR A 104
HIS A 224
ILE A 136
TYR A 164
 None
None
ZN  A 401 ( 3.3A)
None
ZN  A 401 ( 4.2A)
 1.24A 3gwxA-5umhA:
undetectable		 3gwxA-5umhA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 5umh CATECHOL
1,2-DIOXYGENASE
(Burkholderia
multivorans) 		5 / 12 THR A 239
THR A 104
HIS A 224
ILE A 284
TYR A 164
 None
None
ZN  A 401 ( 3.3A)
None
ZN  A 401 ( 4.2A)
 1.28A 3gwxA-5umhA:
undetectable		 3gwxA-5umhA:
21.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HGI_A_BEZA284_0
(CATECHOL
1,2-DIOXYGENASE)		 5umh CATECHOL
1,2-DIOXYGENASE
(Burkholderia
multivorans) 		9 / 12 LEU A  73
ILE A 105
GLY A 107
PRO A 108
TYR A 164
TYR A 200
ARG A 221
HIS A 224
HIS A 226
 None
None
EDO  A 402 (-3.6A)
EDO  A 402 (-4.4A)
ZN  A 401 ( 4.2A)
ZN  A 401 ( 4.7A)
EDO  A 402 (-3.4A)
ZN  A 401 ( 3.3A)
ZN  A 401 ( 3.2A)
 0.52A 3hgiA-5umhA:
27.9		 3hgiA-5umhA:
31.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_F_ASWF101_1
(DNA TOPOISOMERASE
2-BETA)		 5umh CATECHOL
1,2-DIOXYGENASE
(Burkholderia
multivorans) 		4 / 6 ARG A 221
GLY A  77
GLU A  81
GLN A 209
 EDO  A 402 (-3.4A)
None
None
None
 0.96A 4g0uA-5umhA:
undetectable		 4g0uA-5umhA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5umh CATECHOL
1,2-DIOXYGENASE
(Burkholderia
multivorans) 		4 / 5 PRO A 222
ASP A 246
ILE A 262
VAL A 265
 None
 1.34A 4hytA-5umhA:
3.0		 4hytA-5umhA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 5umh CATECHOL
1,2-DIOXYGENASE
(Burkholderia
multivorans) 		5 / 12 THR A 239
THR A 104
ALA A 256
TRP A 250
ASN A 242
 None
 1.50A 4u15A-5umhA:
undetectable		 4u15A-5umhA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_A_AG2A506_1
(HOMOSPERMIDINE
SYNTHASE)		 5umh CATECHOL
1,2-DIOXYGENASE
(Burkholderia
multivorans) 		4 / 6 ARG A 103
ASP A  92
VAL A 301
ASP A 298
 None
 1.10A 4xqeA-5umhA:
undetectable		 4xqeA-5umhA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 5umh CATECHOL
1,2-DIOXYGENASE
(Burkholderia
multivorans) 		4 / 6 ARG A 103
ASP A  92
VAL A 301
ASP A 298
 None
 1.11A 4xqeB-5umhA:
undetectable		 4xqeB-5umhA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_A_AG2A505_1
(HOMOSPERMIDINE
SYNTHASE)		 5umh CATECHOL
1,2-DIOXYGENASE
(Burkholderia
multivorans) 		4 / 8 ARG A 103
ASP A  92
VAL A 301
ASP A 298
 None
 1.10A 4xqgA-5umhA:
undetectable		 4xqgA-5umhA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 5umh CATECHOL
1,2-DIOXYGENASE
(Burkholderia
multivorans) 		4 / 8 ARG A 103
ASP A  92
VAL A 301
ASP A 298
 None
 1.11A 4xqgB-5umhA:
undetectable		 4xqgB-5umhA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA825_0
(GEPHYRIN)		 5umh CATECHOL
1,2-DIOXYGENASE
(Burkholderia
multivorans) 		3 / 3 LYS A 282
VAL A 265
ASP A 267
 None
 0.56A 6fgdA-5umhA:
undetectable		 6fgdA-5umhA:
22.54