SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5umn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_A_SAMA105_0
(MET REPRESSOR)		 5umn HEMAGGLUTININ
(Influenza
A
virus) 		5 / 10 ALA A 113
PHE A  87
GLY A 116
GLU A  89
ARG A 269
 None
 1.33A 1cmcA-5umnA:
undetectable
1cmcB-5umnA:
undetectable		 1cmcA-5umnA:
15.41
1cmcB-5umnA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_B_SAMB105_0
(MET REPRESSOR)		 5umn HEMAGGLUTININ
(Influenza
A
virus) 		5 / 10 GLU A  89
ARG A 269
ALA A 113
PHE A  87
GLY A 116
 None
 1.35A 1cmcA-5umnA:
undetectable
1cmcB-5umnA:
undetectable		 1cmcA-5umnA:
15.41
1cmcB-5umnA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_B_CCSB47_0
(GLUTATHIONE
S-TRANSFERASE)		 5umn HEMAGGLUTININ
(Influenza
A
virus) 		4 / 7 LEU A 194
THR A 155
LEU A 251
GLY A 249
 None
 0.70A 1gtiB-5umnA:
undetectable		 1gtiB-5umnA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_A_SAMA200_0
(METHIONINE REPRESSOR)		 5umn HEMAGGLUTININ
(Influenza
A
virus) 		5 / 11 GLU A  89
ARG A 269
ALA A 113
PHE A  87
GLY A 116
 None
 1.36A 1mjqA-5umnA:
undetectable
1mjqB-5umnA:
undetectable		 1mjqA-5umnA:
15.41
1mjqB-5umnA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_C_SAMC199_0
(METHIONINE REPRESSOR)		 5umn HEMAGGLUTININ
(Influenza
A
virus) 		5 / 10 GLU A  89
ARG A 269
ALA A 113
PHE A  87
GLY A 116
 None
 1.39A 1mjqC-5umnA:
undetectable
1mjqD-5umnA:
undetectable		 1mjqC-5umnA:
15.41
1mjqD-5umnA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_A_J01A1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 5umn HEMAGGLUTININ
(Influenza
A
virus) 		5 / 12 LEU A 164
ILE A 252
ALA A 253
VAL A 202
TYR A 161
 None
 1.27A 2japA-5umnA:
undetectable		 2japA-5umnA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_D_J01D1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 5umn HEMAGGLUTININ
(Influenza
A
virus) 		5 / 12 LEU A 164
ILE A 252
ALA A 253
VAL A 202
TYR A 161
 None
 1.23A 2japD-5umnA:
undetectable		 2japD-5umnA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 5umn HEMAGGLUTININ
(Influenza
A
virus) 		3 / 3 ASP A 172
ASN A 170
THR A 167
 None
 0.71A 2pymB-5umnA:
undetectable		 2pymB-5umnA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		 5umn HEMAGGLUTININ
(Influenza
A
virus) 		4 / 6 LEU A 108
LEU A 111
ILE A  67
ARG A 109
 None
 1.05A 2rlfA-5umnA:
undetectable
2rlfB-5umnA:
undetectable		 2rlfA-5umnA:
11.45
2rlfB-5umnA:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5umn HEMAGGLUTININ
(Influenza
A
virus) 		4 / 6 LEU A 194
TYR A 195
ILE A 252
GLY A 134
 None
 0.98A 4l39A-5umnA:
undetectable		 4l39A-5umnA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		 5umn HEMAGGLUTININ
(Influenza
A
virus) 		4 / 8 HIS A  75
ASN A  96
ARG A 224
THR A  65
 None
 1.08A 5db5A-5umnA:
undetectable
5db5B-5umnA:
undetectable		 5db5A-5umnA:
20.33
5db5B-5umnA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		 5umn HEMAGGLUTININ
(Influenza
A
virus) 		5 / 12 PRO A 254
GLY A 124
PHE A 125
LEU A 243
TYR A 178
 None
 1.45A 5eeiA-5umnA:
undetectable		 5eeiA-5umnA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_B_SHHB801_1
(HDAC6 PROTEIN)		 5umn HEMAGGLUTININ
(Influenza
A
virus) 		5 / 12 PRO A 254
GLY A 124
PHE A 125
LEU A 243
TYR A 178
 None
 1.45A 5eeiB-5umnA:
undetectable		 5eeiB-5umnA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5umn HEMAGGLUTININ
(Influenza
A
virus) 		3 / 3 ARG A 261
PHE A 120
PHE A 174
 None
 0.99A 6nknC-5umnA:
undetectable
6nknJ-5umnA:
undetectable		 6nknC-5umnA:
19.60
6nknJ-5umnA:
12.45