SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ums'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GX8_A_RTLA1163_0
(BETA-LACTOGLOBULIN)
5ums FACT COMPLEX SUBUNIT
SSRP1

(Homo
sapiens)
5 / 9 LEU A 242
LEU A 275
ILE A 216
VAL A 317
MET A 318
None
1.27A 1gx8A-5umsA:
undetectable
1gx8A-5umsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_A_EV1A1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)
5ums FACT COMPLEX SUBUNIT
SSRP1

(Homo
sapiens)
5 / 12 LEU A 352
VAL A 418
ILE A 374
GLU A 373
PHE A 391
None
1.15A 2weyA-5umsA:
undetectable
2weyA-5umsA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)
5ums FACT COMPLEX SUBUNIT
SSRP1

(Homo
sapiens)
4 / 6 HIS A 363
GLN A 252
LEU A 208
LEU A 276
None
0.89A 3bgdA-5umsA:
undetectable
3bgdA-5umsA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)
5ums FACT COMPLEX SUBUNIT
SSRP1

(Homo
sapiens)
4 / 7 HIS A 363
GLN A 252
LEU A 208
LEU A 276
None
0.81A 3bgdB-5umsA:
undetectable
3bgdB-5umsA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)
5ums FACT COMPLEX SUBUNIT
SSRP1

(Homo
sapiens)
4 / 6 GLU A 392
ASP A 372
ARG A 370
GLY A 358
None
0.94A 5cdnT-5umsA:
undetectable
5cdnU-5umsA:
undetectable
5cdnT-5umsA:
9.78
5cdnU-5umsA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Z_BEZZ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)
5ums FACT COMPLEX SUBUNIT
SSRP1

(Homo
sapiens)
4 / 4 ILE A 341
GLY A 350
ILE A 406
LEU A 351
None
0.89A 5dzkl-5umsA:
undetectable
5dzkz-5umsA:
undetectable
5dzkl-5umsA:
undetectable
5dzkz-5umsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)
5ums FACT COMPLEX SUBUNIT
SSRP1

(Homo
sapiens)
4 / 5 PRO A 366
LEU A 205
TYR A 232
PHE A 230
None
1.48A 5igjA-5umsA:
undetectable
5igjA-5umsA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AF6_A_GLYA507_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)
5ums FACT COMPLEX SUBUNIT
SSRP1

(Homo
sapiens)
3 / 3 TYR A 353
HIS A 247
MET A 253
None
1.18A 6af6A-5umsA:
undetectable
6af6A-5umsA:
undetectable