SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5umu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX8_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO)		 5umu FACT COMPLEX SUBUNIT
SPT16
(Homo
sapiens) 		5 / 12 PHE A 797
LEU A 795
ALA A 707
LEU A 708
ILE A 699
 None
 1.10A 1mx8A-5umuA:
undetectable		 1mx8A-5umuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1320_0
(CHLOROPEROXIDASE)		 5umu FACT COMPLEX SUBUNIT
SPT16
(Homo
sapiens) 		4 / 6 ALA A 707
ILE A 784
VAL A 787
GLU A 788
 None
 0.86A 2cizA-5umuA:
undetectable		 2cizA-5umuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 5umu FACT COMPLEX SUBUNIT
SPT16
(Homo
sapiens) 		4 / 8 TYR A 864
MET A 906
THR A 894
LEU A 842
 None
None
FMT  A1006 (-3.7A)
FMT  A1003 ( 3.5A)
 0.78A 2wx2B-5umuA:
undetectable		 2wx2B-5umuA:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWZ_B_BEZB301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5umu FACT COMPLEX SUBUNIT
SPT16
(Homo
sapiens) 		3 / 3 MET A 676
GLN A 677
ARG A 675
 None
None
FMT  A1009 ( 4.6A)
 1.12A 5ewzB-5umuA:
undetectable		 5ewzB-5umuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M35_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5umu FACT COMPLEX SUBUNIT
SPT16
(Homo
sapiens) 		3 / 3 MET A 676
GLN A 677
ARG A 675
 None
None
FMT  A1009 ( 4.6A)
 1.10A 5m35B-5umuA:
undetectable		 5m35B-5umuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M36_A_BEZA303_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5umu FACT COMPLEX SUBUNIT
SPT16
(Homo
sapiens) 		3 / 3 MET A 676
GLN A 677
ARG A 675
 None
None
FMT  A1009 ( 4.6A)
 1.06A 5m36A-5umuA:
undetectable		 5m36A-5umuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA602_0
(THIOCYANATE
DEHYDROGENASE)		 5umu FACT COMPLEX SUBUNIT
SPT16
(Homo
sapiens) 		3 / 3 LYS A 705
HIS A 723
HIS A 706
 None
 1.23A 5oexA-5umuA:
undetectable		 5oexA-5umuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB602_0
(THIOCYANATE
DEHYDROGENASE)		 5umu FACT COMPLEX SUBUNIT
SPT16
(Homo
sapiens) 		3 / 3 LYS A 705
HIS A 723
HIS A 706
 None
 1.28A 5oexB-5umuA:
undetectable		 5oexB-5umuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC603_0
(THIOCYANATE
DEHYDROGENASE)		 5umu FACT COMPLEX SUBUNIT
SPT16
(Homo
sapiens) 		3 / 3 LYS A 705
HIS A 723
HIS A 706
 None
 1.27A 5oexC-5umuA:
undetectable		 5oexC-5umuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD603_0
(THIOCYANATE
DEHYDROGENASE)		 5umu FACT COMPLEX SUBUNIT
SPT16
(Homo
sapiens) 		3 / 3 LYS A 705
HIS A 723
HIS A 706
 None
 1.23A 5oexD-5umuA:
undetectable		 5oexD-5umuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6APH_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5umu FACT COMPLEX SUBUNIT
SPT16
(Homo
sapiens) 		4 / 5 GLN A 818
THR A 836
HIS A 723
LEU A 708
 None
 1.31A 6aphA-5umuA:
undetectable		 6aphA-5umuA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_C_RFPC502_1
(RIFAMPIN
MONOOXYGENASE)		 5umu FACT COMPLEX SUBUNIT
SPT16
(Homo
sapiens) 		5 / 12 VAL A 868
VAL A 860
GLY A 896
ARG A 847
VAL A 848
 None
None
FMT  A1011 ( 4.3A)
None
None
 1.16A 6brdC-5umuA:
undetectable		 6brdC-5umuA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FN9_A_BEZA302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5umu FACT COMPLEX SUBUNIT
SPT16
(Homo
sapiens) 		3 / 3 MET A 676
GLN A 677
ARG A 675
 None
None
FMT  A1009 ( 4.6A)
 1.12A 6fn9A-5umuA:
undetectable		 6fn9A-5umuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNA_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5umu FACT COMPLEX SUBUNIT
SPT16
(Homo
sapiens) 		3 / 3 MET A 676
GLN A 677
ARG A 675
 None
None
FMT  A1009 ( 4.6A)
 1.13A 6fnaB-5umuA:
undetectable		 6fnaB-5umuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNB_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5umu FACT COMPLEX SUBUNIT
SPT16
(Homo
sapiens) 		3 / 3 MET A 676
GLN A 677
ARG A 675
 None
None
FMT  A1009 ( 4.6A)
 1.10A 6fnbA-5umuA:
undetectable		 6fnbA-5umuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_B_ADNB501_2
(-)		 5umu FACT COMPLEX SUBUNIT
SPT16
(Homo
sapiens) 		4 / 5 GLN A 818
THR A 836
HIS A 723
LEU A 708
 None
 1.30A 6gbnB-5umuA:
undetectable		 6gbnB-5umuA:
11.48