SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5un0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_C_REAC503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5un0 PROTEASOME ASSEMBLY
CHAPERONE 2 (PAC2)
HOMOLOGUE RV2125
(Mycobacterium
tuberculosis) 		5 / 10 ILE 1 128
ALA 1 185
ALA 1 148
ILE 1 170
CYH 1 111
 None
 1.16A 2aclC-5un01:
undetectable		 2aclC-5un01:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_A_SAMA501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 5un0 PROTEASOME ASSEMBLY
CHAPERONE 2 (PAC2)
HOMOLOGUE RV2125
(Mycobacterium
tuberculosis) 		4 / 8 CYH 1 111
THR 1 168
GLU 1 102
VAL 1 126
 None
 1.05A 2fb2A-5un01:
undetectable		 2fb2A-5un01:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDY_A_RBFA187_1
(LUMAZINE PROTEIN)		 5un0 PROTEASOME ASSEMBLY
CHAPERONE 2 (PAC2)
HOMOLOGUE RV2125
(Mycobacterium
tuberculosis) 		5 / 12 CYH 1 178
ILE 1 128
ALA 1 185
THR 1 125
ILE 1 183
 None
 1.20A 3ddyA-5un01:
undetectable		 3ddyA-5un01:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_E_NIOE5660_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 5un0 PROTEASOME ASSEMBLY
CHAPERONE 2 (PAC2)
HOMOLOGUE RV2125
(Mycobacterium
tuberculosis) 		3 / 3 GLU 1 219
GLU 1 213
TRP 1  43
 None
 1.35A 3hrdA-5un01:
undetectable
3hrdE-5un01:
undetectable
3hrdF-5un01:
undetectable		 3hrdA-5un01:
21.83
3hrdE-5un01:
21.83
3hrdF-5un01:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FWD_A_BO2A801_1
(TTC1975 PEPTIDASE)		 5un0 PROTEASOME ASSEMBLY
CHAPERONE 2 (PAC2)
HOMOLOGUE RV2125
(Mycobacterium
tuberculosis) 		5 / 9 VAL 1  18
VAL 1  17
VAL 1 117
ILE 1 118
ALA 1 185
 None
 1.16A 4fwdA-5un01:
undetectable		 4fwdA-5un01:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_H_9CRH501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5un0 PROTEASOME ASSEMBLY
CHAPERONE 2 (PAC2)
HOMOLOGUE RV2125
(Mycobacterium
tuberculosis) 		5 / 12 ALA 1  21
ALA 1  20
ALA 1  32
CYH 1 111
LEU 1 114
 None
 1.09A 4nqaH-5un01:
undetectable		 4nqaH-5un01:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_G_IPHG101_0
(INSULIN)		 5un0 PROTEASOME ASSEMBLY
CHAPERONE 2 (PAC2)
HOMOLOGUE RV2125
(Mycobacterium
tuberculosis) 		5 / 11 LEU 1 129
VAL 1  95
LEU 1  97
LEU 1 209
ALA 1  35
 None
 1.09A 4p65B-5un01:
undetectable
4p65D-5un01:
undetectable
4p65G-5un01:
undetectable
4p65H-5un01:
undetectable		 4p65B-5un01:
12.79
4p65D-5un01:
12.79
4p65G-5un01:
5.53
4p65H-5un01:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UXQ_A_0LIA1752_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 5un0 PROTEASOME ASSEMBLY
CHAPERONE 2 (PAC2)
HOMOLOGUE RV2125
(Mycobacterium
tuberculosis) 		4 / 7 VAL 1 123
ILE 1  83
ALA 1  20
ILE 1  51
 None
 0.82A 4uxqA-5un01:
undetectable		 4uxqA-5un01:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5un0 PROTEASOME ASSEMBLY
CHAPERONE 2 (PAC2)
HOMOLOGUE RV2125
(Mycobacterium
tuberculosis) 		5 / 12 ALA 1  21
ALA 1  20
ALA 1  32
CYH 1 111
LEU 1 114
 None
 1.19A 6a5zD-5un01:
undetectable		 6a5zD-5un01:
14.46