SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5un1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5un1 N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR1-3A
(Xenopus
laevis) 		4 / 8 SER G 678
ARG G 521
ASN G 518
ASP G 722
 GLY  G1001 (-3.4A)
GLY  G1001 (-2.7A)
None
GLY  G1001 (-3.0A)
 1.33A 1p6kB-5un1G:
undetectable		 1p6kB-5un1G:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PB9_A_4AXA901_1
(N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT 1)		 5un1 N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR1-3A
(Xenopus
laevis) 		9 / 9 PHE G 482
LEU G 515
THR G 516
ARG G 521
SER G 677
SER G 678
VAL G 679
TRP G 721
ASP G 722
 GLY  G1001 (-3.6A)
GLY  G1001 (-4.4A)
GLY  G1001 (-2.9A)
GLY  G1001 (-2.7A)
None
GLY  G1001 (-3.4A)
None
None
GLY  G1001 (-3.0A)
 0.63A 1pb9A-5un1G:
39.1		 1pb9A-5un1G:
80.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5un1 N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR1-3A
(Xenopus
laevis) 		4 / 8 SER G 678
ARG G 521
ASN G 518
ASP G 722
 GLY  G1001 (-3.4A)
GLY  G1001 (-2.7A)
None
GLY  G1001 (-3.0A)
 1.30A 1rs6B-5un1G:
undetectable		 1rs6B-5un1G:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5un1 N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR1-3A
(Xenopus
laevis) 		4 / 8 SER G 678
ARG G 521
ASN G 518
ASP G 722
 GLY  G1001 (-3.4A)
GLY  G1001 (-2.7A)
None
GLY  G1001 (-3.0A)
 1.31A 1rs7B-5un1G:
undetectable		 1rs7B-5un1G:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5un1 N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR1-3A
(Xenopus
laevis) 		4 / 8 SER G 678
ARG G 521
ASN G 518
ASP G 722
 GLY  G1001 (-3.4A)
GLY  G1001 (-2.7A)
None
GLY  G1001 (-3.0A)
 1.32A 1zzqB-5un1G:
undetectable		 1zzqB-5un1G:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)		 5un1 IONOTROPIC GLUTAMATE
RECEPTOR SUBUNIT
NR2B
(Xenopus
laevis) 		4 / 7 LEU B 780
GLU B 774
TYR B 745
MET B 772
 None
 1.27A 2w8yA-5un1B:
undetectable		 2w8yA-5un1B:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_1
(UNCHARACTERIZED
PROTEIN PH0793)		 5un1 IONOTROPIC GLUTAMATE
RECEPTOR SUBUNIT
NR2B
N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR1-3A
(Xenopus
laevis;
Xenopus
laevis) 		3 / 3 MET B 501
GLU G 473
ASP G 509
 None
 1.05A 3a25A-5un1B:
undetectable		 3a25A-5un1B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_1
(16S RRNA METHYLASE)		 5un1 N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR1-3A
(Xenopus
laevis) 		3 / 3 ASP G 509
GLU G 502
SER G 395
 None
 0.67A 3p2kA-5un1G:
undetectable		 3p2kA-5un1G:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJY_A_BEZA304_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 5un1 N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR1-3A
(Xenopus
laevis) 		3 / 3 MET G 500
GLU G 520
ARG G 521
 None
None
GLY  G1001 (-2.7A)
 1.06A 5tjyA-5un1G:
undetectable		 5tjyA-5un1G:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJZ_A_BEZA302_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 5un1 N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR1-3A
(Xenopus
laevis) 		3 / 3 MET G 500
GLU G 520
ARG G 521
 None
None
GLY  G1001 (-2.7A)
 1.04A 5tjzA-5un1G:
undetectable		 5tjzA-5un1G:
undetectable