SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5una'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_1
(GLYCINE
N-METHYLTRANSFERASE)		 5una 7SK SNRNA
METHYLPHOSPHATE
CAPPING ENZYME
(Homo
sapiens) 		3 / 3 ARG A 433
ASP A 474
ASN A 559
 SAH  A 701 (-3.1A)
SAH  A 701 (-2.8A)
SAH  A 701 (-3.6A)
 0.77A 1nbhA-5unaA:
14.5		 1nbhA-5unaA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_1
(GLYCINE
N-METHYLTRANSFERASE)		 5una 7SK SNRNA
METHYLPHOSPHATE
CAPPING ENZYME
(Homo
sapiens) 		3 / 3 ARG A 433
ASP A 474
ASN A 559
 SAH  A 701 (-3.1A)
SAH  A 701 (-2.8A)
SAH  A 701 (-3.6A)
 0.73A 1nbhD-5unaA:
14.2		 1nbhD-5unaA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_D_T3D602_1
(TRANSTHYRETIN)		 5una 7SK SNRNA
METHYLPHOSPHATE
CAPPING ENZYME
(Homo
sapiens) 		5 / 12 LEU A 579
VAL A 664
LEU A 680
GLU A 440
VAL A 447
 None
 0.96A 1sn5B-5unaA:
undetectable
1sn5D-5unaA:
undetectable		 1sn5B-5unaA:
18.88
1sn5D-5unaA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_D_T3D602_1
(TRANSTHYRETIN)		 5una 7SK SNRNA
METHYLPHOSPHATE
CAPPING ENZYME
(Homo
sapiens) 		5 / 12 LEU A 680
GLU A 440
VAL A 447
LEU A 579
VAL A 664
 None
 0.98A 1sn5B-5unaA:
undetectable
1sn5D-5unaA:
undetectable		 1sn5B-5unaA:
18.88
1sn5D-5unaA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 5una 7SK SNRNA
METHYLPHOSPHATE
CAPPING ENZYME
(Homo
sapiens) 		5 / 12 ASP A 449
GLY A 451
ILE A 475
ASP A 476
LEU A 583
 None
SAH  A 701 (-3.2A)
SAH  A 701 (-3.8A)
None
SAH  A 701 (-4.4A)
 0.64A 2nxeB-5unaA:
13.2		 2nxeB-5unaA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_A_SAMA206_0
(UPF0217 PROTEIN
MJ1640)		 5una 7SK SNRNA
METHYLPHOSPHATE
CAPPING ENZYME
(Homo
sapiens) 		4 / 6 LEU A 579
GLY A 472
LEU A 581
SER A 582
 None
None
SAH  A 701 (-4.4A)
SAH  A 701 (-3.6A)
 0.95A 3aiaA-5unaA:
undetectable		 3aiaA-5unaA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_C_SAMC302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 5una 7SK SNRNA
METHYLPHOSPHATE
CAPPING ENZYME
(Homo
sapiens) 		6 / 12 ASP A 449
GLY A 451
ASP A 474
ILE A 475
ASP A 476
LEU A 583
 None
SAH  A 701 (-3.2A)
SAH  A 701 (-2.8A)
SAH  A 701 (-3.8A)
None
SAH  A 701 (-4.4A)
 0.61A 3cjtC-5unaA:
12.6		 3cjtC-5unaA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_C_SAMC302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 5una 7SK SNRNA
METHYLPHOSPHATE
CAPPING ENZYME
(Homo
sapiens) 		6 / 12 ASP A 449
LEU A 450
GLY A 451
ASP A 474
ASP A 476
LEU A 583
 None
None
SAH  A 701 (-3.2A)
SAH  A 701 (-2.8A)
None
SAH  A 701 (-4.4A)
 0.66A 3cjtC-5unaA:
12.6		 3cjtC-5unaA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_C_SAMC302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 5una 7SK SNRNA
METHYLPHOSPHATE
CAPPING ENZYME
(Homo
sapiens) 		6 / 12 ASP A 449
LEU A 450
GLY A 451
LEU A 457
ASP A 474
ASP A 476
 None
None
SAH  A 701 (-3.2A)
None
SAH  A 701 (-2.8A)
None
 0.90A 3cjtC-5unaA:
12.6		 3cjtC-5unaA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA302_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 5una 7SK SNRNA
METHYLPHOSPHATE
CAPPING ENZYME
(Homo
sapiens) 		4 / 6 LEU A 581
GLU A 616
PRO A 617
ARG A 433
 SAH  A 701 (-4.4A)
SAH  A 701 ( 4.9A)
None
SAH  A 701 (-3.1A)
 1.15A 3ltwA-5unaA:
undetectable		 3ltwA-5unaA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA213_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		 5una 7SK SNRNA
METHYLPHOSPHATE
CAPPING ENZYME
(Homo
sapiens) 		5 / 10 ASN A 552
GLY A 455
PHE A 555
TYR A 490
PHE A 549
 None
 1.28A 3r6wA-5unaA:
undetectable
3r6wB-5unaA:
2.5		 3r6wA-5unaA:
21.55
3r6wB-5unaA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA214_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		 5una 7SK SNRNA
METHYLPHOSPHATE
CAPPING ENZYME
(Homo
sapiens) 		5 / 10 TYR A 490
PHE A 549
ASN A 552
GLY A 455
PHE A 555
 None
 1.22A 3r6wA-5unaA:
undetectable
3r6wB-5unaA:
2.5		 3r6wA-5unaA:
21.55
3r6wB-5unaA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)		 5una 7SK SNRNA
METHYLPHOSPHATE
CAPPING ENZYME
(Homo
sapiens) 		5 / 10 VAL A 447
LEU A 579
VAL A 577
LEU A 437
VAL A 614
 None
 1.04A 4e3hA-5unaA:
undetectable		 4e3hA-5unaA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HOJ_A_ACTA303_0
(REGF PROTEIN)		 5una 7SK SNRNA
METHYLPHOSPHATE
CAPPING ENZYME
(Homo
sapiens) 		4 / 5 VAL A 561
ARG A 602
MET A 599
LEU A 450
 SAH  A 701 (-4.7A)
None
None
None
 1.37A 4hojA-5unaA:
undetectable		 4hojA-5unaA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_A_ADNA401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 5una 7SK SNRNA
METHYLPHOSPHATE
CAPPING ENZYME
(Homo
sapiens) 		5 / 12 GLY A 451
ASP A 474
ILE A 475
ASP A 476
LEU A 583
 SAH  A 701 (-3.2A)
SAH  A 701 (-2.8A)
SAH  A 701 (-3.8A)
None
SAH  A 701 (-4.4A)
 0.53A 6bq4A-5unaA:
10.0		 6bq4A-5unaA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_B_ADNB401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 5una 7SK SNRNA
METHYLPHOSPHATE
CAPPING ENZYME
(Homo
sapiens) 		5 / 12 GLY A 451
ASP A 474
ILE A 475
ASP A 476
LEU A 583
 SAH  A 701 (-3.2A)
SAH  A 701 (-2.8A)
SAH  A 701 (-3.8A)
None
SAH  A 701 (-4.4A)
 0.55A 6bq4B-5unaA:
10.0		 6bq4B-5unaA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HZP_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 5una 7SK SNRNA
METHYLPHOSPHATE
CAPPING ENZYME
(Homo
sapiens) 		4 / 8 VAL A 561
ASN A 559
GLN A 414
ILE A 475
 SAH  A 701 (-4.7A)
SAH  A 701 (-3.6A)
None
SAH  A 701 (-3.8A)
 1.09A 6hzpA-5unaA:
undetectable		 6hzpA-5unaA:
21.38