SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5unc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_M_TRPM81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5unc PHOSPHOENOLPYRUVATE
PHOSPHOMUTASE
(Streptomyces
platensis) 		5 / 11 GLY A 102
ALA A 157
HIS A 111
ILE A 126
ALA A 156
 None
 1.14A 1gtnM-5uncA:
undetectable
1gtnN-5uncA:
undetectable		 1gtnM-5uncA:
14.00
1gtnN-5uncA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_U_TRPU81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5unc PHOSPHOENOLPYRUVATE
PHOSPHOMUTASE
(Streptomyces
platensis) 		5 / 10 GLY A 102
ALA A 157
HIS A 111
ILE A 126
ALA A 156
 None
 1.13A 1gtnU-5uncA:
undetectable
1gtnV-5uncA:
undetectable		 1gtnU-5uncA:
14.00
1gtnV-5uncA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_T_TRPT81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5unc PHOSPHOENOLPYRUVATE
PHOSPHOMUTASE
(Streptomyces
platensis) 		5 / 10 GLY A 102
ALA A 157
HIS A 111
ILE A 126
ALA A 156
 None
 1.17A 1utdT-5uncA:
undetectable
1utdU-5uncA:
undetectable		 1utdT-5uncA:
14.00
1utdU-5uncA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA471_1
(CYTOCHROME P450 51)		 5unc PHOSPHOENOLPYRUVATE
PHOSPHOMUTASE
(Streptomyces
platensis) 		4 / 8 TYR A 231
PHE A 137
ALA A 250
HIS A 252
 None
None
TLA  A 401 (-3.5A)
None
 1.02A 1x8vA-5uncA:
undetectable		 1x8vA-5uncA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		 5unc PHOSPHOENOLPYRUVATE
PHOSPHOMUTASE
(Streptomyces
platensis) 		4 / 6 ASP A 100
SER A  64
LEU A  61
GLY A  60
 None
None
TLA  A 401 (-4.0A)
TLA  A 401 ( 4.0A)
 0.94A 2j2pA-5uncA:
undetectable
2j2pC-5uncA:
undetectable		 2j2pA-5uncA:
20.17
2j2pC-5uncA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		 5unc PHOSPHOENOLPYRUVATE
PHOSPHOMUTASE
(Streptomyces
platensis) 		4 / 6 ASP A 100
SER A  64
LEU A  61
GLY A  60
 None
None
TLA  A 401 (-4.0A)
TLA  A 401 ( 4.0A)
 0.96A 2j2pD-5uncA:
undetectable
2j2pF-5uncA:
undetectable		 2j2pD-5uncA:
20.17
2j2pF-5uncA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J5M_A_ACTA1321_0
(CHLOROPEROXIDASE)		 5unc PHOSPHOENOLPYRUVATE
PHOSPHOMUTASE
(Streptomyces
platensis) 		4 / 6 PHE A 150
ILE A 154
VAL A 168
ALA A 157
 None
 0.86A 2j5mA-5uncA:
undetectable		 2j5mA-5uncA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_1
(AAC(6')-IB)		 5unc PHOSPHOENOLPYRUVATE
PHOSPHOMUTASE
(Streptomyces
platensis) 		5 / 12 GLY A 102
TYR A 116
ASP A  98
ASP A  71
ASP A  73
 None
None
TLA  A 401 (-3.3A)
TLA  A 401 (-3.1A)
None
 1.38A 2vqyA-5uncA:
undetectable		 2vqyA-5uncA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 5unc PHOSPHOENOLPYRUVATE
PHOSPHOMUTASE
(Streptomyces
platensis) 		5 / 10 MET A 167
ALA A  22
ALA A  26
MET A 246
VAL A  34
 None
 1.34A 2wuzA-5uncA:
undetectable		 2wuzA-5uncA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 5unc PHOSPHOENOLPYRUVATE
PHOSPHOMUTASE
(Streptomyces
platensis) 		5 / 10 MET A 167
ALA A  22
ALA A  26
MET A 246
VAL A  34
 None
 1.35A 2wuzB-5uncA:
undetectable		 2wuzB-5uncA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_1
(N-METHYLTRANSFERASE)		 5unc PHOSPHOENOLPYRUVATE
PHOSPHOMUTASE
(Streptomyces
platensis) 		3 / 3 TYR A 103
TYR A 116
GLU A 127
 None
None
TLA  A 401 ( 4.6A)
 0.92A 3pfgA-5uncA:
2.6		 3pfgA-5uncA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_0
(MNMC2)		 5unc PHOSPHOENOLPYRUVATE
PHOSPHOMUTASE
(Streptomyces
platensis) 		5 / 12 TYR A 191
TYR A 103
ALA A 177
PHE A 150
LEU A 144
 None
 1.06A 3vywA-5uncA:
undetectable		 3vywA-5uncA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_0
(MNMC2)		 5unc PHOSPHOENOLPYRUVATE
PHOSPHOMUTASE
(Streptomyces
platensis) 		5 / 12 TYR A 191
TYR A 103
ALA A 177
PHE A 150
LEU A 144
 None
 1.02A 3vywC-5uncA:
undetectable		 3vywC-5uncA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_0
(MNMC2)		 5unc PHOSPHOENOLPYRUVATE
PHOSPHOMUTASE
(Streptomyces
platensis) 		5 / 12 TYR A 191
TYR A 103
ALA A 177
PHE A 150
LEU A 144
 None
 1.06A 3vywD-5uncA:
undetectable		 3vywD-5uncA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TZC_D_EF2D505_1
(PROTEIN CEREBLON)		 5unc PHOSPHOENOLPYRUVATE
PHOSPHOMUTASE
(Streptomyces
platensis) 		4 / 8 TYR A 103
THR A  76
HIS A 111
PHE A 166
 None
 1.24A 4tzcB-5uncA:
undetectable
4tzcD-5uncA:
undetectable		 4tzcB-5uncA:
13.86
4tzcD-5uncA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5unc PHOSPHOENOLPYRUVATE
PHOSPHOMUTASE
(Streptomyces
platensis) 		5 / 10 GLY A 102
ALA A 157
HIS A 111
ILE A 126
ALA A 156
 None
 1.18A 5eeuO-5uncA:
undetectable
5eeuP-5uncA:
undetectable		 5eeuO-5uncA:
14.00
5eeuP-5uncA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5unc PHOSPHOENOLPYRUVATE
PHOSPHOMUTASE
(Streptomyces
platensis) 		5 / 10 GLY A 102
ALA A 157
HIS A 111
ILE A 126
ALA A 156
 None
 1.18A 5eevO-5uncA:
undetectable
5eevP-5uncA:
undetectable		 5eevO-5uncA:
14.00
5eevP-5uncA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5unc PHOSPHOENOLPYRUVATE
PHOSPHOMUTASE
(Streptomyces
platensis) 		5 / 10 GLY A 102
ALA A 157
HIS A 111
ILE A 126
ALA A 156
 None
 1.18A 5eewO-5uncA:
undetectable
5eewP-5uncA:
undetectable		 5eewO-5uncA:
14.00
5eewP-5uncA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5unc PHOSPHOENOLPYRUVATE
PHOSPHOMUTASE
(Streptomyces
platensis) 		5 / 10 GLY A 102
ALA A 157
HIS A 111
ILE A 126
ALA A 156
 None
 1.18A 5eexO-5uncA:
undetectable
5eexP-5uncA:
undetectable		 5eexO-5uncA:
14.00
5eexP-5uncA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5unc PHOSPHOENOLPYRUVATE
PHOSPHOMUTASE
(Streptomyces
platensis) 		5 / 10 GLY A 102
ALA A 157
HIS A 111
ILE A 126
ALA A 156
 None
 1.18A 5eeyO-5uncA:
undetectable
5eeyP-5uncA:
undetectable		 5eeyO-5uncA:
14.00
5eeyP-5uncA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5unc PHOSPHOENOLPYRUVATE
PHOSPHOMUTASE
(Streptomyces
platensis) 		5 / 10 GLY A 102
ALA A 157
HIS A 111
ILE A 126
ALA A 156
 None
 1.18A 5eezO-5uncA:
undetectable
5eezP-5uncA:
undetectable		 5eezO-5uncA:
14.00
5eezP-5uncA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5unc PHOSPHOENOLPYRUVATE
PHOSPHOMUTASE
(Streptomyces
platensis) 		5 / 10 GLY A 102
ALA A 157
HIS A 111
ILE A 126
ALA A 156
 None
 1.18A 5ef0O-5uncA:
undetectable
5ef0P-5uncA:
undetectable		 5ef0O-5uncA:
14.00
5ef0P-5uncA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5unc PHOSPHOENOLPYRUVATE
PHOSPHOMUTASE
(Streptomyces
platensis) 		5 / 10 GLY A 102
ALA A 157
HIS A 111
ILE A 126
ALA A 156
 None
 1.18A 5ef1O-5uncA:
undetectable
5ef1P-5uncA:
undetectable		 5ef1O-5uncA:
14.00
5ef1P-5uncA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5unc PHOSPHOENOLPYRUVATE
PHOSPHOMUTASE
(Streptomyces
platensis) 		5 / 10 GLY A 102
ALA A 157
HIS A 111
ILE A 126
ALA A 156
 None
 1.18A 5ef2O-5uncA:
undetectable
5ef2P-5uncA:
undetectable		 5ef2O-5uncA:
14.00
5ef2P-5uncA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5unc PHOSPHOENOLPYRUVATE
PHOSPHOMUTASE
(Streptomyces
platensis) 		5 / 10 GLY A 102
ALA A 157
HIS A 111
ILE A 126
ALA A 156
 None
 1.18A 5ef3O-5uncA:
undetectable
5ef3P-5uncA:
undetectable		 5ef3O-5uncA:
14.00
5ef3P-5uncA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5unc PHOSPHOENOLPYRUVATE
PHOSPHOMUTASE
(Streptomyces
platensis) 		4 / 5 TYR A 249
SER A 235
ALA A 236
THR A  33
 None
 1.30A 5n0tA-5uncA:
undetectable		 5n0tA-5uncA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5unc PHOSPHOENOLPYRUVATE
PHOSPHOMUTASE
(Streptomyces
platensis) 		3 / 3 SER A 235
ALA A 236
THR A  33
 None
 0.73A 5n0xB-5uncA:
undetectable		 5n0xB-5uncA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_A_ECLA1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 5unc PHOSPHOENOLPYRUVATE
PHOSPHOMUTASE
(Streptomyces
platensis) 		4 / 7 ILE A 201
LEU A 200
ILE A 234
ALA A 250
 None
None
None
TLA  A 401 (-3.5A)
 0.86A 6b5vA-5uncA:
undetectable
6b5vC-5uncA:
undetectable		 6b5vA-5uncA:
14.64
6b5vC-5uncA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_C_ECLC1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 5unc PHOSPHOENOLPYRUVATE
PHOSPHOMUTASE
(Streptomyces
platensis) 		4 / 7 ILE A 201
LEU A 200
ILE A 234
ALA A 250
 None
None
None
TLA  A 401 (-3.5A)
 0.86A 6b5vC-5uncA:
undetectable
6b5vD-5uncA:
undetectable		 6b5vC-5uncA:
14.64
6b5vD-5uncA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_D_ECLD1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 5unc PHOSPHOENOLPYRUVATE
PHOSPHOMUTASE
(Streptomyces
platensis) 		4 / 7 ALA A 250
ILE A 201
LEU A 200
ILE A 234
 TLA  A 401 (-3.5A)
None
None
None
 0.86A 6b5vB-5uncA:
undetectable
6b5vD-5uncA:
undetectable		 6b5vB-5uncA:
14.64
6b5vD-5uncA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		 5unc PHOSPHOENOLPYRUVATE
PHOSPHOMUTASE
(Streptomyces
platensis) 		5 / 12 VAL A  96
TYR A 103
VAL A 248
GLU A  62
GLY A  38
 None
 1.35A 6gngB-5uncA:
undetectable		 6gngB-5uncA:
21.97