SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5uni'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		 5uni NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA
(Thermus
thermophilus) 		5 / 9 ALA B  96
GLU B 103
VAL B 218
GLY B 122
GLY B 125
 None
BEN  B 310 (-3.3A)
None
None
None
 1.28A 1bcuH-5uniB:
undetectable		 1bcuH-5uniB:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FO4_B_SALB4005_1
(XANTHINE
DEHYDROGENASE)		 5uni NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA
(Thermus
thermophilus) 		4 / 7 PHE B 190
THR B 164
VAL B 165
ALA B 158
 None
None
PEG  B 308 ( 4.1A)
None
 1.04A 1fo4B-5uniB:
undetectable		 1fo4B-5uniB:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA501_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5uni NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA
(Thermus
thermophilus) 		4 / 7 PHE B 109
ALA B 118
ILE B  99
GLU B 221
 BEN  B 310 ( 4.2A)
None
None
None
 1.12A 1oniA-5uniB:
undetectable
1oniB-5uniB:
undetectable		 1oniA-5uniB:
19.17
1oniB-5uniB:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI517_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5uni NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA
(Thermus
thermophilus) 		4 / 7 ILE B  99
GLU B 221
PHE B 109
ALA B 118
 None
None
BEN  B 310 ( 4.2A)
None
 1.01A 1oniG-5uniB:
undetectable
1oniI-5uniB:
undetectable		 1oniG-5uniB:
19.17
1oniI-5uniB:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_B_X2NB1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 5uni NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA
(Thermus
thermophilus) 		5 / 12 PHE B 184
ALA B 162
ALA B 100
ALA B 118
LEU B 172
 PEG  B 309 ( 4.4A)
None
None
None
None
 1.21A 2x2nB-5uniB:
undetectable		 2x2nB-5uniB:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB2_A_IBPA3960_1
(LACTOTRANSFERRIN)		 5uni NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA
(Thermus
thermophilus) 		4 / 4 GLY B 222
VAL B 225
GLY B 113
THR B 112
 None
BEN  B 310 (-4.3A)
PEG  B 306 (-3.6A)
None
 0.94A 3ib2A-5uniB:
undetectable		 3ib2A-5uniB:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FAK_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 5uni NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA
(Thermus
thermophilus) 		5 / 10 ILE B 124
GLY B 125
GLY B  93
PHE B 209
SER B 208
 None
 0.94A 4fakA-5uniB:
1.8		 4fakA-5uniB:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_B_ASWB1301_1
(DNA TOPOISOMERASE
2-BETA)		 5uni NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA
(Thermus
thermophilus) 		4 / 7 ILE B 119
GLY B 219
ALA B 100
GLU B 221
 PEG  B 308 ( 4.6A)
None
None
None
 0.89A 4g0uB-5uniB:
3.2		 4g0uB-5uniB:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_B_ASWB1301_1
(DNA TOPOISOMERASE
2-BETA)		 5uni NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA
(Thermus
thermophilus) 		4 / 7 ILE B 119
GLY B 222
ALA B 100
GLU B 221
 PEG  B 308 ( 4.6A)
None
None
None
 0.89A 4g0uB-5uniB:
3.2		 4g0uB-5uniB:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5uni NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA
(Thermus
thermophilus) 		5 / 10 ALA B 229
ALA B  42
GLY B 219
GLY B 234
ALA B 233
 None
 1.07A 4qw3K-5uniB:
undetectable
4qw3L-5uniB:
undetectable		 4qw3K-5uniB:
20.97
4qw3L-5uniB:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5uni NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA
(Thermus
thermophilus) 		5 / 10 ALA B 229
ALA B  42
GLY B 219
GLY B 234
ALA B 233
 None
 1.07A 4qw3Y-5uniB:
undetectable
4qw3Z-5uniB:
undetectable		 4qw3Y-5uniB:
20.97
4qw3Z-5uniB:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5uni NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA
(Thermus
thermophilus) 		5 / 9 ALA B 229
ALA B  42
GLY B 219
GLY B 234
ALA B 233
 None
 1.07A 5d0xK-5uniB:
undetectable
5d0xL-5uniB:
undetectable		 5d0xK-5uniB:
20.97
5d0xL-5uniB:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5uni NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA
(Thermus
thermophilus) 		5 / 9 ALA B 229
ALA B  42
GLY B 219
GLY B 234
ALA B 233
 None
 1.07A 5d0xY-5uniB:
undetectable
5d0xZ-5uniB:
undetectable		 5d0xY-5uniB:
20.97
5d0xZ-5uniB:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_2
(SCRFP-TAG,GP41)		 5uni NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA
(Thermus
thermophilus) 		4 / 7 GLN B 153
LEU B 196
ALA B 135
LEU B 139
 BEN  B 312 (-4.3A)
None
None
None
 1.11A 5nwvA-5uniB:
undetectable		 5nwvA-5uniB:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 5uni NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA
(Thermus
thermophilus) 		5 / 12 LEU B 123
PHE B 190
VAL B 127
ALA B 128
GLY B 131
 PEG  B 308 ( 4.6A)
None
None
None
None
 1.17A 5tzoB-5uniB:
undetectable		 5tzoB-5uniB:
20.97