SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5unl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQU_A_EQIA329_0
(PROTEIN (ESTRADIOL
17
BETA-DEHYDROGENASE
1))		 5unl 3-KETOACYL-ACP
REDUCTASE
(Burkholderia
multivorans) 		5 / 10 SER A 148
VAL A 149
LEU A 265
TYR A 161
GLY A 192
 NO3  A 306 ( 4.5A)
None
None
None
None
 0.83A 1equA-5unlA:
26.6		 1equA-5unlA:
27.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_A_ESTA351_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 5unl 3-KETOACYL-ACP
REDUCTASE
(Burkholderia
multivorans) 		5 / 12 SER A 148
VAL A 149
LEU A 265
TYR A 161
GLY A 192
 NO3  A 306 ( 4.5A)
None
None
None
None
 0.86A 1fduA-5unlA:
26.5		 1fduA-5unlA:
27.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAY_A_ADNA1001_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 5unl 3-KETOACYL-ACP
REDUCTASE
(Burkholderia
multivorans) 		7 / 11 GLY A  19
ALA A  21
SER A  22
ASP A  43
ASP A  67
VAL A  68
ALA A  95
 None
 0.85A 1uayA-5unlA:
29.9		 1uayA-5unlA:
29.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAY_B_ADNB1002_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 5unl 3-KETOACYL-ACP
REDUCTASE
(Burkholderia
multivorans) 		7 / 10 GLY A  19
ALA A  21
SER A  22
ASP A  43
ASP A  67
VAL A  68
ALA A  95
 None
 0.86A 1uayB-5unlA:
30.0		 1uayB-5unlA:
29.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 5unl 3-KETOACYL-ACP
REDUCTASE
(Burkholderia
multivorans) 		5 / 12 ILE A  28
ALA A  27
GLY A  23
ILE A 236
GLY A  19
 None
 0.90A 2qe6B-5unlA:
6.5		 2qe6B-5unlA:
25.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_B_SAMB1267_1
(NON-STRUCTURAL
PROTEIN 5)		 5unl 3-KETOACYL-ACP
REDUCTASE
(Burkholderia
multivorans) 		3 / 3 SER A   4
HIS A 249
ASP A  89
 None
 0.81A 2wa2B-5unlA:
5.5		 2wa2B-5unlA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_B_ADNB353_2
(ADENOSINE KINASE)		 5unl 3-KETOACYL-ACP
REDUCTASE
(Burkholderia
multivorans) 		4 / 5 SER A 148
ILE A  24
TYR A 161
GLY A 192
 NO3  A 306 ( 4.5A)
None
None
None
 1.04A 3uboB-5unlA:
5.7		 3uboB-5unlA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 5unl 3-KETOACYL-ACP
REDUCTASE
(Burkholderia
multivorans) 		5 / 9 GLU A 178
ILE A 184
VAL A 186
ALA A 130
ILE A 143
 None
 1.06A 4lbgB-5unlA:
5.9		 4lbgB-5unlA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_A_15UA301_1
(THROMBIN HEAVY CHAIN)		 5unl 3-KETOACYL-ACP
REDUCTASE
(Burkholderia
multivorans) 		5 / 10 HIS A  40
LEU A  16
ALA A  48
ALA A  63
GLY A  19
 None
 1.33A 4rn6A-5unlA:
undetectable		 4rn6A-5unlA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_H_TR6H101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 5unl 3-KETOACYL-ACP
REDUCTASE
(Burkholderia
multivorans) 		3 / 5 GLY A 211
GLY A 213
GLU A 216
 None
EDO  A 305 (-3.1A)
EDO  A 305 (-3.5A)
 0.48A 4z2eA-5unlA:
undetectable
4z2eD-5unlA:
2.7		 4z2eA-5unlA:
21.39
4z2eD-5unlA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_A_FK5A201_1
(FK506-BINDING
PROTEIN 1)		 5unl 3-KETOACYL-ACP
REDUCTASE
(Burkholderia
multivorans) 		5 / 11 TYR A 161
TYR A 221
ILE A 203
ILE A 236
ILE A  24
 None
EDO  A 301 (-3.6A)
None
None
None
 1.14A 5hw8A-5unlA:
undetectable
5hw8D-5unlA:
undetectable		 5hw8A-5unlA:
19.62
5hw8D-5unlA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JI6_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME)		 5unl 3-KETOACYL-ACP
REDUCTASE
(Burkholderia
multivorans) 		4 / 5 GLY A 151
LEU A 153
SER A 257
GLN A 190
 None
 1.34A 6ji6A-5unlA:
undetectable		 6ji6A-5unlA:
19.41