SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5unn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPM_A_SAMA300_0
(PROTEIN
(ADENINE-SPECIFIC
METHYLTRANSFERASE
DPNII 1))		 5unn NADPH-DEPENDENT
GLYOXYLATE/HYDROXYPY
RUVATE REDUCTASE
(Sinorhizobium
meliloti) 		5 / 12 GLY A 250
PHE A 229
GLY A 254
GLY A 253
ALA A 226
 None
None
GOL  A 401 ( 4.2A)
GOL  A 401 (-4.8A)
None
 1.05A 2dpmA-5unnA:
3.7		 2dpmA-5unnA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F84_A_SAMA501_0
(GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E)		 5unn NADPH-DEPENDENT
GLYOXYLATE/HYDROXYPY
RUVATE REDUCTASE
(Sinorhizobium
meliloti) 		5 / 12 GLY A 143
GLY A 167
VAL A 197
LEU A 158
VAL A 140
 None
 1.13A 4f84A-5unnA:
6.8		 4f84A-5unnA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_A_SAMA301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 5unn NADPH-DEPENDENT
GLYOXYLATE/HYDROXYPY
RUVATE REDUCTASE
(Sinorhizobium
meliloti) 		5 / 12 ALA A 285
GLY A 233
LEU A 202
ALA A 284
GLU A 261
 None
 0.93A 4lg1A-5unnA:
4.7		 4lg1A-5unnA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_B_SAMB301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 5unn NADPH-DEPENDENT
GLYOXYLATE/HYDROXYPY
RUVATE REDUCTASE
(Sinorhizobium
meliloti) 		5 / 12 ALA A 285
GLY A 233
LEU A 202
ALA A 284
GLU A 261
 None
 0.95A 4lg1B-5unnA:
4.1		 4lg1B-5unnA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2O_C_CLQC1079_0
(SAPOSIN-B)		 5unn NADPH-DEPENDENT
GLYOXYLATE/HYDROXYPY
RUVATE REDUCTASE
(Sinorhizobium
meliloti) 		4 / 5 ARG A 115
MET A 161
GLU A 136
LEU A 114
 None
 1.30A 4v2oA-5unnA:
undetectable
4v2oC-5unnA:
undetectable		 4v2oA-5unnA:
12.46
4v2oC-5unnA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD9_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5unn NADPH-DEPENDENT
GLYOXYLATE/HYDROXYPY
RUVATE REDUCTASE
(Sinorhizobium
meliloti) 		4 / 7 VAL A 289
PHE A  93
HIS A 295
GLU A 297
 None
 1.21A 5ad9A-5unnA:
undetectable
5ad9B-5unnA:
undetectable		 5ad9A-5unnA:
21.44
5ad9B-5unnA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHG_C_SAMC4001_0
(RNA-DIRECTED RNA
POLYMERASE NS5)		 5unn NADPH-DEPENDENT
GLYOXYLATE/HYDROXYPY
RUVATE REDUCTASE
(Sinorhizobium
meliloti) 		5 / 12 GLY A 148
GLY A 233
GLY A 198
GLY A 151
VAL A 259
 None
 0.95A 5ehgC-5unnA:
3.9		 5ehgC-5unnA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5B_A_SAMA1001_0
(NS5
METHYLTRANSFERASE)		 5unn NADPH-DEPENDENT
GLYOXYLATE/HYDROXYPY
RUVATE REDUCTASE
(Sinorhizobium
meliloti) 		5 / 12 GLY A 148
GLY A 233
GLY A 198
GLY A 151
VAL A 259
 None
 0.94A 5m5bA-5unnA:
undetectable		 5m5bA-5unnA:
22.22