SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5uoh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_0
(PROTEIN (METHIONINE
REPRESSOR))		 5uoh CARBOXYLESTERASE A
(Mycobacterium
tuberculosis) 		5 / 9 GLU A 408
ARG A 411
LEU A 265
GLU A 262
ALA A 263
 None
 1.38A 1mj2C-5uohA:
undetectable		 1mj2C-5uohA:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_0
(METHIONINE REPRESSOR)		 5uoh CARBOXYLESTERASE A
(Mycobacterium
tuberculosis) 		5 / 9 GLU A 408
ARG A 411
LEU A 265
GLU A 262
ALA A 263
 None
 1.46A 1mjoA-5uohA:
undetectable		 1mjoA-5uohA:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_1
(METHIONINE REPRESSOR)		 5uoh CARBOXYLESTERASE A
(Mycobacterium
tuberculosis) 		5 / 9 GLU A 408
ARG A 411
LEU A 265
GLU A 262
ALA A 263
 None
 1.48A 1mjoB-5uohA:
undetectable		 1mjoB-5uohA:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_0
(METHIONINE REPRESSOR)		 5uoh CARBOXYLESTERASE A
(Mycobacterium
tuberculosis) 		5 / 9 GLU A 408
ARG A 411
LEU A 265
GLU A 262
ALA A 263
 None
 1.43A 1mjoC-5uohA:
undetectable		 1mjoC-5uohA:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ND4_A_KANA1300_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E)		 5uoh CARBOXYLESTERASE A
(Mycobacterium
tuberculosis) 		5 / 10 ASP A 259
ASP A 407
ARG A 411
ASP A 401
GLU A 264
 None
 1.40A 1nd4A-5uohA:
undetectable		 1nd4A-5uohA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ND4_B_KANB2300_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E)		 5uoh CARBOXYLESTERASE A
(Mycobacterium
tuberculosis) 		5 / 9 ASP A 259
ASP A 407
ARG A 411
ASP A 401
GLU A 264
 None
 1.42A 1nd4B-5uohA:
undetectable		 1nd4B-5uohA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_C_2FAC308_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5uoh CARBOXYLESTERASE A
(Mycobacterium
tuberculosis) 		5 / 11 GLY A 202
VAL A 206
SER A 442
ASP A 395
ILE A 391
 None
 1.09A 1pk9C-5uohA:
undetectable		 1pk9C-5uohA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 5uoh CARBOXYLESTERASE A
(Mycobacterium
tuberculosis) 		4 / 8 GLY A 174
ILE A 178
VAL A 175
PRO A 429
 None
 0.88A 1rxcB-5uohA:
undetectable		 1rxcB-5uohA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_C_URFC2081_1
(URIDINE
PHOSPHORYLASE)		 5uoh CARBOXYLESTERASE A
(Mycobacterium
tuberculosis) 		4 / 7 GLY A 174
ILE A 178
VAL A 175
PRO A 429
 None
 1.04A 1rxcC-5uohA:
undetectable		 1rxcC-5uohA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_D_URFD2021_1
(URIDINE
PHOSPHORYLASE)		 5uoh CARBOXYLESTERASE A
(Mycobacterium
tuberculosis) 		4 / 7 GLY A 174
ILE A 178
VAL A 175
PRO A 429
 None
 1.04A 1rxcD-5uohA:
undetectable		 1rxcD-5uohA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_E_URFE2031_1
(URIDINE
PHOSPHORYLASE)		 5uoh CARBOXYLESTERASE A
(Mycobacterium
tuberculosis) 		4 / 8 GLY A 174
ILE A 178
VAL A 175
PRO A 429
 None
 0.96A 1rxcE-5uohA:
undetectable		 1rxcE-5uohA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_F_URFF2001_1
(URIDINE
PHOSPHORYLASE)		 5uoh CARBOXYLESTERASE A
(Mycobacterium
tuberculosis) 		4 / 7 GLY A 174
ILE A 178
VAL A 175
PRO A 429
 None
 0.91A 1rxcF-5uohA:
undetectable		 1rxcF-5uohA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_I_URFI2041_1
(URIDINE
PHOSPHORYLASE)		 5uoh CARBOXYLESTERASE A
(Mycobacterium
tuberculosis) 		4 / 8 GLY A 174
ILE A 178
VAL A 175
PRO A 429
 None
 0.90A 1rxcI-5uohA:
undetectable		 1rxcI-5uohA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_K_URFK2061_1
(URIDINE
PHOSPHORYLASE)		 5uoh CARBOXYLESTERASE A
(Mycobacterium
tuberculosis) 		4 / 8 GLY A 174
ILE A 178
VAL A 175
PRO A 429
 None
 0.89A 1rxcK-5uohA:
undetectable		 1rxcK-5uohA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_L_URFL2071_1
(URIDINE
PHOSPHORYLASE)		 5uoh CARBOXYLESTERASE A
(Mycobacterium
tuberculosis) 		4 / 7 GLY A 174
ILE A 178
VAL A 175
PRO A 429
 None
 0.88A 1rxcL-5uohA:
undetectable		 1rxcL-5uohA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_A_HSMA401_1
(NITROPHORIN 1)		 5uoh CARBOXYLESTERASE A
(Mycobacterium
tuberculosis) 		4 / 4 ASP A 370
LEU A 365
LEU A 368
LEU A 366
 None
 1.34A 1u18A-5uohA:
undetectable		 1u18A-5uohA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		 5uoh CARBOXYLESTERASE A
(Mycobacterium
tuberculosis) 		4 / 4 LEU A 217
PRO A 108
ILE A  92
LEU A  91
 None
 1.04A 1ya4C-5uohA:
13.9		 1ya4C-5uohA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 5uoh CARBOXYLESTERASE A
(Mycobacterium
tuberculosis) 		4 / 8 PHE A  94
GLY A 138
VAL A 105
LEU A 217
 None
 1.05A 3bgdB-5uohA:
undetectable		 3bgdB-5uohA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 5uoh CARBOXYLESTERASE A
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 145
SER A 146
ILE A 116
LEU A 136
TYR A 227
 None
 1.17A 3k2hA-5uohA:
undetectable		 3k2hA-5uohA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_C_30BC500_1
(GENOME POLYPROTEIN)		 5uoh CARBOXYLESTERASE A
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 112
VAL A 105
GLY A 115
ARG A 142
ASP A 209
 None
 1.09A 3keeC-5uohA:
undetectable		 3keeC-5uohA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_B_TPVB100_1
(HIV-1 PROTEASE)		 5uoh CARBOXYLESTERASE A
(Mycobacterium
tuberculosis) 		5 / 9 LEU A 225
ALA A 247
VAL A 456
GLY A 510
ILE A 509
 None
 1.27A 3spkA-5uohA:
undetectable		 3spkA-5uohA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAW_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 5uoh CARBOXYLESTERASE A
(Mycobacterium
tuberculosis) 		5 / 11 GLY A 202
VAL A 206
SER A 442
ASP A 395
ILE A 391
 None
 1.11A 3uawA-5uohA:
undetectable		 3uawA-5uohA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_B_ADNB401_2
(PUTATIVE ADENOSINE
KINASE)		 5uoh CARBOXYLESTERASE A
(Mycobacterium
tuberculosis) 		4 / 5 LEU A 350
ALA A 279
THR A 337
PHE A 275
 None
 1.29A 3vasB-5uohA:
undetectable		 3vasB-5uohA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_B_SAMB1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 5uoh CARBOXYLESTERASE A
(Mycobacterium
tuberculosis) 		5 / 12 ASP A 324
TYR A 381
GLY A 379
LEU A 365
GLY A 362
 None
 1.06A 4blvB-5uohA:
undetectable		 4blvB-5uohA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_A_URFA1301_1
(URIDINE
PHOSPHORYLASE)		 5uoh CARBOXYLESTERASE A
(Mycobacterium
tuberculosis) 		4 / 8 GLY A 174
ILE A 178
VAL A 175
PRO A 429
 None
 0.95A 4e1vA-5uohA:
undetectable		 4e1vA-5uohA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_B_URFB1301_1
(URIDINE
PHOSPHORYLASE)		 5uoh CARBOXYLESTERASE A
(Mycobacterium
tuberculosis) 		4 / 7 GLY A 174
ILE A 178
VAL A 175
PRO A 429
 None
 0.91A 4e1vB-5uohA:
undetectable		 4e1vB-5uohA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_C_URFC1301_1
(URIDINE
PHOSPHORYLASE)		 5uoh CARBOXYLESTERASE A
(Mycobacterium
tuberculosis) 		4 / 8 GLY A 174
ILE A 178
VAL A 175
PRO A 429
 None
 0.97A 4e1vC-5uohA:
undetectable		 4e1vC-5uohA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_D_URFD1301_1
(URIDINE
PHOSPHORYLASE)		 5uoh CARBOXYLESTERASE A
(Mycobacterium
tuberculosis) 		4 / 8 GLY A 174
ILE A 178
VAL A 175
PRO A 429
 None
 0.98A 4e1vD-5uohA:
undetectable		 4e1vD-5uohA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_E_URFE1301_1
(URIDINE
PHOSPHORYLASE)		 5uoh CARBOXYLESTERASE A
(Mycobacterium
tuberculosis) 		4 / 8 GLY A 174
ILE A 178
VAL A 175
PRO A 429
 None
 0.93A 4e1vE-5uohA:
undetectable		 4e1vE-5uohA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_H_URFH1301_1
(URIDINE
PHOSPHORYLASE)		 5uoh CARBOXYLESTERASE A
(Mycobacterium
tuberculosis) 		4 / 8 GLY A 174
ILE A 178
VAL A 175
PRO A 429
 None
 0.95A 4e1vH-5uohA:
undetectable		 4e1vH-5uohA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_A_GNTA604_1
(ACETYLCHOLINESTERASE)		 5uoh CARBOXYLESTERASE A
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 109
GLY A 110
SER A 228
TYR A 342
HIS A 490
 None
 0.81A 4ey6A-5uohA:
14.3		 4ey6A-5uohA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5uoh CARBOXYLESTERASE A
(Mycobacterium
tuberculosis) 		4 / 6 GLU A 181
THR A 182
GLN A 167
ASN A 159
 None
 1.37A 4pfjB-5uohA:
undetectable		 4pfjB-5uohA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LRB_A_ACRA1003_1
(ALPHA-1,4 GLUCAN
PHOSPHORYLASE)		 5uoh CARBOXYLESTERASE A
(Mycobacterium
tuberculosis) 		4 / 6 GLU A 240
THR A 441
TYR A  79
PHE A 241
 None
 1.25A 5lrbA-5uohA:
3.8		 5lrbA-5uohA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_B_RITB602_1
(CYTOCHROME P450 3A5)		 5uoh CARBOXYLESTERASE A
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 508
PHE A 494
ILE A 249
ILE A 213
GLY A 138
 None
 0.96A 5veuB-5uohA:
undetectable		 5veuB-5uohA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_B_RBFB502_2
(RIBOFLAVIN LYASE)		 5uoh CARBOXYLESTERASE A
(Mycobacterium
tuberculosis) 		4 / 4 ASN A 276
GLN A 272
ASP A 273
THR A 461
 None
 1.29A 5w4zB-5uohA:
undetectable		 5w4zB-5uohA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 5uoh CARBOXYLESTERASE A
(Mycobacterium
tuberculosis) 		4 / 6 ASP A 259
GLN A 396
GLU A 262
ALA A 412
 None
 1.25A 6djzB-5uohA:
undetectable		 6djzB-5uohA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5uoh CARBOXYLESTERASE A
(Mycobacterium
tuberculosis) 		4 / 6 MET A 248
ALA A 253
LEU A 474
ALA A 475
 None
 1.21A 6fosB-5uohA:
undetectable		 6fosB-5uohA:
9.79