SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5uos'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_A_GBNA2414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 5uos METHYLMALONIC
ACIDURIA AND
HOMOCYSTINURIA TYPE
C PROTEIN
(Homo
sapiens) 		4 / 8 TYR A  31
THR A 119
ALA A 120
ALA A 121
 None
B12  A 301 ( 2.7A)
None
None
 0.56A 2ej3A-5uosA:
undetectable		 2ej3A-5uosA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5uos METHYLMALONIC
ACIDURIA AND
HOMOCYSTINURIA TYPE
C PROTEIN
(Homo
sapiens) 		5 / 9 LEU A  97
LEU A  94
ILE A  12
LEU A  48
ILE A 169
 None
 1.25A 2f78B-5uosA:
undetectable		 2f78B-5uosA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 5uos METHYLMALONIC
ACIDURIA AND
HOMOCYSTINURIA TYPE
C PROTEIN
(Homo
sapiens) 		5 / 11 LEU A  51
LEU A 166
VAL A 164
LEU A  53
VAL A  90
 None
 1.19A 2uxoB-5uosA:
undetectable		 2uxoB-5uosA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5uos METHYLMALONIC
ACIDURIA AND
HOMOCYSTINURIA TYPE
C PROTEIN
(Homo
sapiens) 		5 / 9 ALA A 120
PHE A  26
LEU A  87
VAL A  90
ILE A 101
 None
None
171  A 304 ( 3.7A)
None
171  A 304 (-4.4A)
 1.37A 3claA-5uosA:
undetectable		 3claA-5uosA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_2
(DIHYDROFOLATE
REDUCTASE)		 5uos METHYLMALONIC
ACIDURIA AND
HOMOCYSTINURIA TYPE
C PROTEIN
(Homo
sapiens) 		3 / 3 ARG A 214
ILE A 150
THR A 185
 None
 0.65A 3ia4D-5uosA:
undetectable		 3ia4D-5uosA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A83_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 5uos METHYLMALONIC
ACIDURIA AND
HOMOCYSTINURIA TYPE
C PROTEIN
(Homo
sapiens) 		5 / 12 PRO A  25
PHE A  50
LEU A  94
GLN A  10
ALA A   6
 None
 1.36A 4a83A-5uosA:
undetectable		 4a83A-5uosA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V30_B_LVYB151_1
(CEREBLON ISOFORM 4)		 5uos METHYLMALONIC
ACIDURIA AND
HOMOCYSTINURIA TYPE
C PROTEIN
(Homo
sapiens) 		4 / 8 PRO A  56
PHE A 154
TRP A 157
TYR A 205
 None
 1.50A 4v30B-5uosA:
undetectable		 4v30B-5uosA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_B_SAMB505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 5uos METHYLMALONIC
ACIDURIA AND
HOMOCYSTINURIA TYPE
C PROTEIN
(Homo
sapiens) 		5 / 12 GLY A 162
ILE A 101
HIS A  86
CYH A  82
GLY A  88
 None
171  A 304 (-4.4A)
None
None
171  A 304 ( 4.0A)
 0.85A 6bp4B-5uosA:
undetectable		 6bp4B-5uosA:
21.27