SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5uou'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NNC_A_ZMRA479_1
(NEURAMINIDASE N9)		 5uou 2-OXO-4-HYDROXY-4-CA
RBOXY-5-UREIDOIMIDAZ
OLINE (OHCU)
DECARBOXYLASE
(Klebsiella
pneumoniae) 		5 / 12 ALA A 150
GLU A 147
GLU A 144
ARG A 136
TYR A 109
 None
 1.39A 1nncA-5uouA:
undetectable		 1nncA-5uouA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2477_1
(NEURAMINIDASE)		 5uou 2-OXO-4-HYDROXY-4-CA
RBOXY-5-UREIDOIMIDAZ
OLINE (OHCU)
DECARBOXYLASE
(Klebsiella
pneumoniae) 		5 / 12 ALA A 150
GLU A 147
GLU A 144
ARG A 136
TYR A 109
 None
 1.40A 2cmlB-5uouA:
undetectable		 2cmlB-5uouA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3477_1
(NEURAMINIDASE)		 5uou 2-OXO-4-HYDROXY-4-CA
RBOXY-5-UREIDOIMIDAZ
OLINE (OHCU)
DECARBOXYLASE
(Klebsiella
pneumoniae) 		5 / 12 ALA A 150
GLU A 147
GLU A 144
ARG A 136
TYR A 109
 None
 1.38A 2cmlC-5uouA:
undetectable		 2cmlC-5uouA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN6_A_T44A1370_1
(THYROXINE-BINDING
GLOBULIN)		 5uou 2-OXO-4-HYDROXY-4-CA
RBOXY-5-UREIDOIMIDAZ
OLINE (OHCU)
DECARBOXYLASE
(Klebsiella
pneumoniae) 		5 / 10 ALA A 163
LEU A  32
LEU A 160
LEU A  19
ARG A 159
 None
 1.16A 2xn6A-5uouA:
undetectable
2xn6B-5uouA:
undetectable		 2xn6A-5uouA:
20.96
2xn6B-5uouA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_A_BCZA468_0
(NEURAMINIDASE)		 5uou 2-OXO-4-HYDROXY-4-CA
RBOXY-5-UREIDOIMIDAZ
OLINE (OHCU)
DECARBOXYLASE
(Klebsiella
pneumoniae) 		5 / 12 ALA A 150
GLU A 147
GLU A 144
ARG A 136
TYR A 109
 None
 1.42A 3k37A-5uouA:
undetectable		 3k37A-5uouA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_A_BCZA1001_0
(NEURAMINIDASE)		 5uou 2-OXO-4-HYDROXY-4-CA
RBOXY-5-UREIDOIMIDAZ
OLINE (OHCU)
DECARBOXYLASE
(Klebsiella
pneumoniae) 		5 / 12 ALA A 150
GLU A 147
GLU A 144
ARG A 136
TYR A 109
 None
 1.43A 3k39A-5uouA:
undetectable		 3k39A-5uouA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_E_BCZE1001_0
(NEURAMINIDASE)		 5uou 2-OXO-4-HYDROXY-4-CA
RBOXY-5-UREIDOIMIDAZ
OLINE (OHCU)
DECARBOXYLASE
(Klebsiella
pneumoniae) 		5 / 12 ALA A 150
GLU A 147
GLU A 144
ARG A 136
TYR A 109
 None
 1.42A 3k39E-5uouA:
undetectable		 3k39E-5uouA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_F_BCZF1001_0
(NEURAMINIDASE)		 5uou 2-OXO-4-HYDROXY-4-CA
RBOXY-5-UREIDOIMIDAZ
OLINE (OHCU)
DECARBOXYLASE
(Klebsiella
pneumoniae) 		5 / 12 ALA A 150
GLU A 147
GLU A 144
ARG A 136
TYR A 109
 None
 1.43A 3k39F-5uouA:
undetectable		 3k39F-5uouA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_G_BCZG1001_0
(NEURAMINIDASE)		 5uou 2-OXO-4-HYDROXY-4-CA
RBOXY-5-UREIDOIMIDAZ
OLINE (OHCU)
DECARBOXYLASE
(Klebsiella
pneumoniae) 		5 / 12 ALA A 150
GLU A 147
GLU A 144
ARG A 136
TYR A 109
 None
 1.42A 3k39G-5uouA:
undetectable		 3k39G-5uouA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_H_BCZH1001_0
(NEURAMINIDASE)		 5uou 2-OXO-4-HYDROXY-4-CA
RBOXY-5-UREIDOIMIDAZ
OLINE (OHCU)
DECARBOXYLASE
(Klebsiella
pneumoniae) 		5 / 12 ALA A 150
GLU A 147
GLU A 144
ARG A 136
TYR A 109
 None
 1.43A 3k39H-5uouA:
undetectable		 3k39H-5uouA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_M_BCZM1001_0
(NEURAMINIDASE)		 5uou 2-OXO-4-HYDROXY-4-CA
RBOXY-5-UREIDOIMIDAZ
OLINE (OHCU)
DECARBOXYLASE
(Klebsiella
pneumoniae) 		5 / 12 ALA A 150
GLU A 147
GLU A 144
ARG A 136
TYR A 109
 None
 1.42A 3k39M-5uouA:
undetectable		 3k39M-5uouA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_N_BCZN1001_0
(NEURAMINIDASE)		 5uou 2-OXO-4-HYDROXY-4-CA
RBOXY-5-UREIDOIMIDAZ
OLINE (OHCU)
DECARBOXYLASE
(Klebsiella
pneumoniae) 		5 / 12 ALA A 150
GLU A 147
GLU A 144
ARG A 136
TYR A 109
 None
 1.42A 3k39N-5uouA:
undetectable		 3k39N-5uouA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_P_BCZP1001_0
(NEURAMINIDASE)		 5uou 2-OXO-4-HYDROXY-4-CA
RBOXY-5-UREIDOIMIDAZ
OLINE (OHCU)
DECARBOXYLASE
(Klebsiella
pneumoniae) 		5 / 12 ALA A 150
GLU A 147
GLU A 144
ARG A 136
TYR A 109
 None
 1.42A 3k39P-5uouA:
undetectable		 3k39P-5uouA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SAN_A_ZMRA901_1
(NEURAMINIDASE)		 5uou 2-OXO-4-HYDROXY-4-CA
RBOXY-5-UREIDOIMIDAZ
OLINE (OHCU)
DECARBOXYLASE
(Klebsiella
pneumoniae) 		5 / 12 ALA A 150
GLU A 147
GLU A 144
ARG A 136
TYR A 109
 None
 1.39A 3sanA-5uouA:
undetectable		 3sanA-5uouA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SAN_B_ZMRB901_1
(NEURAMINIDASE)		 5uou 2-OXO-4-HYDROXY-4-CA
RBOXY-5-UREIDOIMIDAZ
OLINE (OHCU)
DECARBOXYLASE
(Klebsiella
pneumoniae) 		5 / 12 ALA A 150
GLU A 147
GLU A 144
ARG A 136
TYR A 109
 None
 1.38A 3sanB-5uouA:
undetectable		 3sanB-5uouA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_A_ZMRA1002_1
(NEURAMINIDASE)		 5uou 2-OXO-4-HYDROXY-4-CA
RBOXY-5-UREIDOIMIDAZ
OLINE (OHCU)
DECARBOXYLASE
(Klebsiella
pneumoniae) 		5 / 12 ALA A 150
GLU A 147
GLU A 144
ARG A 136
TYR A 109
 None
 1.39A 3ticA-5uouA:
undetectable		 3ticA-5uouA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_B_ZMRB1002_1
(NEURAMINIDASE)		 5uou 2-OXO-4-HYDROXY-4-CA
RBOXY-5-UREIDOIMIDAZ
OLINE (OHCU)
DECARBOXYLASE
(Klebsiella
pneumoniae) 		5 / 12 ALA A 150
GLU A 147
GLU A 144
ARG A 136
TYR A 109
 None
 1.37A 3ticB-5uouA:
undetectable		 3ticB-5uouA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_C_ZMRC1002_1
(NEURAMINIDASE)		 5uou 2-OXO-4-HYDROXY-4-CA
RBOXY-5-UREIDOIMIDAZ
OLINE (OHCU)
DECARBOXYLASE
(Klebsiella
pneumoniae) 		5 / 12 ALA A 150
GLU A 147
GLU A 144
ARG A 136
TYR A 109
 None
 1.38A 3ticC-5uouA:
undetectable		 3ticC-5uouA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_D_ZMRD1002_1
(NEURAMINIDASE)		 5uou 2-OXO-4-HYDROXY-4-CA
RBOXY-5-UREIDOIMIDAZ
OLINE (OHCU)
DECARBOXYLASE
(Klebsiella
pneumoniae) 		5 / 12 ALA A 150
GLU A 147
GLU A 144
ARG A 136
TYR A 109
 None
 1.38A 3ticD-5uouA:
undetectable		 3ticD-5uouA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA5_A_ZMRA501_1
(NEURAMINIDASE)		 5uou 2-OXO-4-HYDROXY-4-CA
RBOXY-5-UREIDOIMIDAZ
OLINE (OHCU)
DECARBOXYLASE
(Klebsiella
pneumoniae) 		5 / 12 ALA A 150
GLU A 147
GLU A 144
ARG A 136
TYR A 109
 None
 1.46A 4wa5A-5uouA:
undetectable		 4wa5A-5uouA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_4_BEZ4801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5uou 2-OXO-4-HYDROXY-4-CA
RBOXY-5-UREIDOIMIDAZ
OLINE (OHCU)
DECARBOXYLASE
(Klebsiella
pneumoniae) 		4 / 5 LEU A 130
PHE A 117
ILE A 129
ILE A 119
 None
 1.01A 5dzk4-5uouA:
undetectable
5dzkg-5uouA:
undetectable
5dzkm-5uouA:
undetectable
5dzkn-5uouA:
undetectable		 5dzk4-5uouA:
4.44
5dzkg-5uouA:
23.85
5dzkm-5uouA:
26.91
5dzkn-5uouA:
26.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_4_BEZ4801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5uou 2-OXO-4-HYDROXY-4-CA
RBOXY-5-UREIDOIMIDAZ
OLINE (OHCU)
DECARBOXYLASE
(Klebsiella
pneumoniae) 		4 / 5 PHE A 117
ARG A 124
ILE A 129
ILE A 119
 None
 1.01A 5dzk4-5uouA:
undetectable
5dzkg-5uouA:
undetectable
5dzkm-5uouA:
undetectable
5dzkn-5uouA:
undetectable		 5dzk4-5uouA:
4.44
5dzkg-5uouA:
23.85
5dzkm-5uouA:
26.91
5dzkn-5uouA:
26.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JI0_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5uou 2-OXO-4-HYDROXY-4-CA
RBOXY-5-UREIDOIMIDAZ
OLINE (OHCU)
DECARBOXYLASE
(Klebsiella
pneumoniae) 		5 / 11 GLN A   6
LEU A  10
PHE A   7
LEU A   4
ALA A   3
 None
 1.16A 5ji0A-5uouA:
undetectable		 5ji0A-5uouA:
23.63