SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5uow'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_D_DVAD8_0
(GRAMICIDIN A)		 5uow N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR1-8A
(Xenopus
laevis) 		3 / 3 TRP A 606
VAL A 611
TRP A 609
 None
 1.48A 1gmkC-5uowA:
undetectable
1gmkD-5uowA:
undetectable		 1gmkC-5uowA:
3.90
1gmkD-5uowA:
3.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PB9_A_4AXA901_1
(N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT 1)		 5uow N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR1-8A
(Xenopus
laevis) 		5 / 9 PHE A 482
LEU A 515
ARG A 521
SER A 685
SER A 686
 None
 1.16A 1pb9A-5uowA:
35.6		 1pb9A-5uowA:
34.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PB9_A_4AXA901_1
(N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT 1)		 5uow N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR1-8A
(Xenopus
laevis) 		6 / 9 PHE A 482
LEU A 515
THR A 516
ARG A 521
SER A 685
ASP A 730
 None
 1.20A 1pb9A-5uowA:
35.6		 1pb9A-5uowA:
34.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_B_SAMB4001_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 5uow N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR1-8A
(Xenopus
laevis) 		6 / 12 GLY A 250
LEU A 248
LEU A 221
VAL A 150
LEU A 269
ILE A 353
 None
 1.14A 1zq9B-5uowA:
undetectable		 1zq9B-5uowA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_A_PPFA3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 5uow N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR1-8A
(Xenopus
laevis) 		4 / 8 HIS A 146
SER A 145
ASP A 345
ALA A 175
 None
 1.38A 2rk8A-5uowA:
undetectable		 2rk8A-5uowA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5uow N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR1-8A
(Xenopus
laevis) 		5 / 12 PHE A 531
ILE A 774
PHE A 470
VAL A 474
ILE A 400
 None
 1.15A 3em0B-5uowA:
undetectable		 3em0B-5uowA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)		 5uow N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR1-8A
(Xenopus
laevis) 		5 / 12 GLY A 250
GLN A 147
ARG A 124
LEU A 361
ILE A 266
 None
 1.28A 3h52A-5uowA:
undetectable		 3h52A-5uowA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_H_PZIH800_0
(GLUTAMATE RECEPTOR 2)		 5uow N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR1-8A
(Xenopus
laevis) 		4 / 8 TYR A 533
SER A 777
SER A 528
LYS A 532
 None
 1.10A 3lsfH-5uowA:
27.0		 3lsfH-5uowA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE)		 5uow N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR1-8A
(Xenopus
laevis) 		4 / 8 SER A 686
ARG A 521
ASN A 518
ASP A 730
 None
 1.33A 3n62A-5uowA:
undetectable		 3n62A-5uowA:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 5uow N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR1-8A
(Xenopus
laevis) 		3 / 3 GLY A 268
TRP A 151
VAL A 150
 None
 0.67A 3n62B-5uowA:
undetectable		 3n62B-5uowA:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N65_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 5uow N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR1-8A
(Xenopus
laevis) 		3 / 3 GLY A 268
TRP A 151
VAL A 150
 None
 0.66A 3n65B-5uowA:
undetectable		 3n65B-5uowA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 5uow N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR1-8A
(Xenopus
laevis) 		3 / 3 GLY A 268
TRP A 151
VAL A 150
 None
 0.67A 3n66B-5uowA:
undetectable		 3n66B-5uowA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 5uow N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR1-8A
(Xenopus
laevis) 		4 / 8 SER A 686
ARG A 521
ASN A 518
ASP A 730
 None
 1.27A 3n66B-5uowA:
undetectable		 3n66B-5uowA:
19.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QEL_D_QELD2_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 5uow N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR1-8A
(Xenopus
laevis) 		4 / 5 TYR A 109
THR A 110
PHE A 113
ARG A 115
 None
 0.84A 3qelC-5uowA:
45.9		 3qelC-5uowA:
93.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QEL_D_QELD2_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 5uow N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR1-8A
(Xenopus
laevis) 		4 / 5 TYR A 109
THR A 110
PHE A 113
LEU A 135
 None
 0.94A 3qelC-5uowA:
45.9		 3qelC-5uowA:
93.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 5uow N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR1-8A
(Xenopus
laevis) 		3 / 3 PHE A 736
SER A 739
GLN A 794
 None
 0.89A 3smtA-5uowA:
undetectable		 3smtA-5uowA:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_2
(PROTEASE)		 5uow N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR1-8A
(Xenopus
laevis) 		5 / 12 GLY A 112
ALA A 111
ILE A  90
VAL A  78
VAL A 118
 None
 0.87A 3ucbB-5uowA:
undetectable		 3ucbB-5uowA:
8.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_0
(METHYLTRANSFERASE
WBDD)		 5uow N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR1-8A
(Xenopus
laevis) 		5 / 12 GLY A  30
ALA A  62
ILE A  90
VAL A  87
ILE A 116
 None
 1.12A 4aztA-5uowA:
undetectable		 4aztA-5uowA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_2
(TRANSPORTER)		 5uow N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR1-8A
(Xenopus
laevis) 		3 / 3 SER A 602
MET A 605
ASP A 579
 None
 0.98A 4mm4B-5uowA:
undetectable		 4mm4B-5uowA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 5uow N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR1-8A
(Xenopus
laevis) 		5 / 12 VAL A 288
ILE A 292
ILE A 119
GLY A 120
LEU A  33
 None
 0.95A 4y8wC-5uowA:
undetectable		 4y8wC-5uowA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA602_0
(THIOCYANATE
DEHYDROGENASE)		 5uow N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR1-8A
(Xenopus
laevis) 		3 / 3 LYS A 706
HIS A 703
HIS A 707
 None
 1.36A 5oexA-5uowA:
undetectable		 5oexA-5uowA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB602_0
(THIOCYANATE
DEHYDROGENASE)		 5uow N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR1-8A
(Xenopus
laevis) 		3 / 3 LYS A 706
HIS A 703
HIS A 707
 None
 1.46A 5oexB-5uowA:
undetectable		 5oexB-5uowA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC603_0
(THIOCYANATE
DEHYDROGENASE)		 5uow N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR1-8A
(Xenopus
laevis) 		3 / 3 LYS A 706
HIS A 703
HIS A 707
 None
 1.41A 5oexC-5uowA:
undetectable		 5oexC-5uowA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD603_0
(THIOCYANATE
DEHYDROGENASE)		 5uow N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR1-8A
(Xenopus
laevis) 		3 / 3 LYS A 706
HIS A 703
HIS A 707
 None
 1.36A 5oexD-5uowA:
undetectable		 5oexD-5uowA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5uow N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR1-8A
(Xenopus
laevis) 		4 / 8 SER A 686
ARG A 521
ASN A 518
ASP A 730
 None
 1.29A 5vunB-5uowA:
undetectable		 5vunB-5uowA:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_ACTB804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5uow N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR1-8A
(Xenopus
laevis) 		3 / 3 GLY A 268
TRP A 151
VAL A 150
 None
 0.62A 5vuoB-5uowA:
undetectable		 5vuoB-5uowA:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5uow N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR1-8A
(Xenopus
laevis) 		4 / 8 SER A 686
ARG A 521
ASN A 518
ASP A 730
 None
 1.29A 5vuoB-5uowA:
undetectable		 5vuoB-5uowA:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5uow N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR1-8A
(Xenopus
laevis) 		3 / 3 GLY A 365
VAL A 150
MET A 154
 None
 0.51A 5ycpA-5uowA:
undetectable		 5ycpA-5uowA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AF6_A_GLYA507_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 5uow N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR1-8A
(Xenopus
laevis) 		3 / 3 TYR A 709
HIS A 707
MET A 704
 None
 1.24A 6af6A-5uowA:
undetectable		 6af6A-5uowA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5uow N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR1-8A
(Xenopus
laevis) 		4 / 8 SER A 686
ARG A 521
ASN A 518
ASP A 730
 None
 1.27A 6auuB-5uowA:
undetectable		 6auuB-5uowA:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 5uow N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR1-8A
(Xenopus
laevis) 		3 / 3 ASN A 311
PRO A 305
GLN A  86
 None
 0.84A 6jnhA-5uowA:
undetectable		 6jnhA-5uowA:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 5uow N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR1-8A
(Xenopus
laevis) 		3 / 3 ASN A 311
PRO A 305
GLN A  86
 None
 0.82A 6jogA-5uowA:
undetectable		 6jogA-5uowA:
12.45