SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5up2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA8_0
(GRAMICIDIN A)		 5up2 N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR2A
(Xenopus
laevis) 		3 / 4 VAL B 284
TRP B 335
TRP B  49
 None
 1.21A 1gmkA-5up2B:
undetectable
1gmkB-5up2B:
undetectable		 1gmkA-5up2B:
1.82
1gmkB-5up2B:
1.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9Q_B_CHDB500_0
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 5up2 N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR2A
(Xenopus
laevis) 		4 / 4 LEU B 151
VAL B 149
ILE B 153
TRP B 190
 None
 1.48A 1s9qB-5up2B:
undetectable		 1s9qB-5up2B:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_C_URFC999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 5up2 N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR2A
(Xenopus
laevis) 		4 / 5 ALA B 235
TYR B 230
ILE B 231
ASP B 204
 None
 1.15A 1upfC-5up2B:
5.2		 1upfC-5up2B:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		 5up2 N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR2A
(Xenopus
laevis) 		4 / 5 VAL B 701
VAL B 722
ASP B 719
SER B 499
 None
 1.33A 2x45A-5up2B:
undetectable		 2x45A-5up2B:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		 5up2 N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR2A
(Xenopus
laevis) 		4 / 5 VAL B 701
VAL B 722
ASP B 719
SER B 499
 None
 1.29A 2x45C-5up2B:
undetectable		 2x45C-5up2B:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_B_QELB1_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 5up2 N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR2A
(Xenopus
laevis) 		5 / 11 ALA B 100
ILE B 104
PHE B 107
PRO B 170
GLU B 227
 None
 0.79A 3qelA-5up2B:
25.3
3qelB-5up2B:
37.2		 3qelA-5up2B:
19.26
3qelB-5up2B:
49.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QEL_D_QELD2_2
(GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 5up2 N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR2A
(Xenopus
laevis) 		5 / 9 ALA B 100
ILE B 104
PHE B 107
PRO B 170
GLU B 227
 None
 0.82A 3qelD-5up2B:
36.2		 3qelD-5up2B:
49.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PE5_B_QELB920_1
(GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 1
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 5up2 N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR2A
(Xenopus
laevis) 		5 / 10 ALA B 100
ILE B 104
PHE B 107
PRO B 170
GLU B 227
 None
 0.81A 4pe5A-5up2B:
25.1
4pe5B-5up2B:
28.2		 4pe5A-5up2B:
29.17
4pe5B-5up2B:
71.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PE5_C_QELC939_1
(GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 1
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 5up2 N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR2A
(Xenopus
laevis) 		5 / 10 ALA B 100
ILE B 104
PHE B 107
PRO B 170
GLU B 227
 None
 0.87A 4pe5C-5up2B:
23.7
4pe5D-5up2B:
38.4		 4pe5C-5up2B:
29.17
4pe5D-5up2B:
71.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5up2 N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR2A
(Xenopus
laevis) 		5 / 10 GLY B 289
ALA B 294
ILE B 290
SER B 296
ALA B 295
 None
 1.22A 5eevO-5up2B:
undetectable
5eevP-5up2B:
undetectable		 5eevO-5up2B:
6.62
5eevP-5up2B:
6.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5up2 N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR2A
(Xenopus
laevis) 		5 / 10 GLY B 289
ALA B 294
ILE B 290
SER B 296
ALA B 295
 None
 1.22A 5eewO-5up2B:
undetectable
5eewP-5up2B:
undetectable		 5eewO-5up2B:
6.62
5eewP-5up2B:
6.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5up2 N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR2A
(Xenopus
laevis) 		5 / 10 GLY B 289
ALA B 294
ILE B 290
SER B 296
ALA B 295
 None
 1.22A 5eexO-5up2B:
undetectable
5eexP-5up2B:
undetectable		 5eexO-5up2B:
6.62
5eexP-5up2B:
6.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_B_QELB503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 5up2 N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR2A
(Xenopus
laevis) 		5 / 11 ALA B 100
ILE B 104
PHE B 107
PRO B 170
GLU B 227
 None
 0.80A 5ewjA-5up2B:
25.1
5ewjB-5up2B:
37.2		 5ewjA-5up2B:
18.85
5ewjB-5up2B:
49.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_D_QELD503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 5up2 N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR2A
(Xenopus
laevis) 		5 / 12 ALA B 100
ILE B 104
PHE B 107
PRO B 170
GLU B 227
 None
 0.81A 5ewjC-5up2B:
25.3
5ewjD-5up2B:
37.2		 5ewjC-5up2B:
18.85
5ewjD-5up2B:
49.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5up2 N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR2A
(Xenopus
laevis) 		5 / 12 GLY B 474
HIS B 473
VAL B 468
ALA B 509
VAL B 489
 None
 0.94A 5n0oA-5up2B:
2.5		 5n0oA-5up2B:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5up2 N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR2A
(Xenopus
laevis) 		5 / 12 GLY B 474
HIS B 473
VAL B 468
ALA B 509
VAL B 489
 None
 0.95A 5n0oB-5up2B:
2.0		 5n0oB-5up2B:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5up2 N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR2A
(Xenopus
laevis) 		5 / 12 GLY B 474
HIS B 473
VAL B 468
ALA B 509
VAL B 489
 None
 0.94A 5n0rA-5up2B:
2.2		 5n0rA-5up2B:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5up2 N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR2A
(Xenopus
laevis) 		5 / 12 GLY B 474
HIS B 473
VAL B 468
ALA B 509
VAL B 489
 None
 0.96A 5n0sA-5up2B:
2.2		 5n0sA-5up2B:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5up2 N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR2A
(Xenopus
laevis) 		5 / 12 GLY B 474
HIS B 473
VAL B 468
ALA B 509
VAL B 489
 None
 0.98A 5n0tA-5up2B:
2.5		 5n0tA-5up2B:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5up2 N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR2A
(Xenopus
laevis) 		5 / 12 GLY B 474
HIS B 473
VAL B 468
ALA B 509
VAL B 489
 None
 0.96A 5n0wA-5up2B:
2.5		 5n0wA-5up2B:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5up2 N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR2A
(Xenopus
laevis) 		5 / 12 GLY B 474
HIS B 473
VAL B 468
ALA B 509
VAL B 489
 None
 0.95A 5n0wB-5up2B:
2.2		 5n0wB-5up2B:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5up2 N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR2A
(Xenopus
laevis) 		5 / 12 GLY B 474
HIS B 473
VAL B 468
ALA B 509
VAL B 489
 None
 0.94A 5n0xA-5up2B:
2.2		 5n0xA-5up2B:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5up2 N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR2A
(Xenopus
laevis) 		5 / 12 GLY B 474
HIS B 473
VAL B 468
ALA B 509
VAL B 489
 None
 0.96A 5n0xB-5up2B:
undetectable		 5n0xB-5up2B:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5up2 N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR2A
(Xenopus
laevis) 		5 / 12 GLY B 474
HIS B 473
VAL B 468
ALA B 509
VAL B 489
 None
 0.97A 5n4iA-5up2B:
2.2		 5n4iA-5up2B:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_2
(WTFP-TAG,GP41)		 5up2 N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR2A
(Xenopus
laevis) 		3 / 3 LEU B 554
LEU B 553
TRP B 597
 None
 0.61A 5nwuA-5up2B:
undetectable		 5nwuA-5up2B:
3.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNA_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 5up2 N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR2A
(Xenopus
laevis) 		3 / 3 ARG B 283
LYS B 352
TYR B 347
 None
 0.97A 6gnaA-5up2B:
undetectable		 6gnaA-5up2B:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNB_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 5up2 N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR2A
(Xenopus
laevis) 		3 / 3 ARG B 283
LYS B 352
TYR B 347
 None
 0.97A 6gnbA-5up2B:
undetectable		 6gnbA-5up2B:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		 5up2 N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR2A
(Xenopus
laevis) 		5 / 12 GLY B 498
LEU B 399
VAL B 397
THR B 519
GLY B 520
 None
 1.06A 6gngA-5up2B:
undetectable		 6gngA-5up2B:
21.23