SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5upy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1E7B_A_HLTA4002_1 (SERUM ALBUMIN)	5upy	INOSINE-5'-MONOPHOSP HATE DEHYDROGENASE (Listeria monocytogenes)	4 / 4	ARG A 288 ALA A 287 ALA A 331 GLU A 333	None	1.15A	1e7bA-5upyA: undetectable	1e7bA-5upyA: 18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1E7B_B_HLTB4002_1 (SERUM ALBUMIN)	5upy	INOSINE-5'-MONOPHOSP HATE DEHYDROGENASE (Listeria monocytogenes)	4 / 4	ARG A 288 ALA A 287 ALA A 331 GLU A 333	None	1.15A	1e7bB-5upyA: undetectable	1e7bB-5upyA: 18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1E7C_A_HLTA4002_1 (SERUM ALBUMIN)	5upy	INOSINE-5'-MONOPHOSP HATE DEHYDROGENASE (Listeria monocytogenes)	4 / 5	ARG A 288 ALA A 287 ALA A 331 GLU A 333	None	1.21A	1e7cA-5upyA: undetectable	1e7cA-5upyA: 18.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1JR1_A_MOAA1332_1 (INOSINE-5'-MONOPHOSP HATE DEHYDROGENASE 2)	5upy	INOSINE-5'-MONOPHOSP HATE DEHYDROGENASE (Listeria monocytogenes)	5 / 11	ASN A 280 GLY A 303 CYH A 308 THR A 310 GLY A 392	IMP A 500 ( 4.3A) None IMP A 500 (-3.2A) Q21 A 501 (-4.3A) IMP A 500 ( 3.3A)	0.42A	1jr1A-5upyA: 50.0	1jr1A-5upyA: 30.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1JR1_A_MOAA1332_1 (INOSINE-5'-MONOPHOSP HATE DEHYDROGENASE 2)	5upy	INOSINE-5'-MONOPHOSP HATE DEHYDROGENASE (Listeria monocytogenes)	5 / 11	ASP A 251 ASN A 280 GLY A 303 CYH A 308 THR A 310	None IMP A 500 ( 4.3A) None IMP A 500 (-3.2A) Q21 A 501 (-4.3A)	0.78A	1jr1A-5upyA: 50.0	1jr1A-5upyA: 30.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1JR1_B_MOAB1333_1 (INOSINE-5'-MONOPHOSP HATE DEHYDROGENASE 2)	5upy	INOSINE-5'-MONOPHOSP HATE DEHYDROGENASE (Listeria monocytogenes)	4 / 8	ASN A 280 GLY A 303 THR A 310 GLY A 392	IMP A 500 ( 4.3A) None Q21 A 501 (-4.3A) IMP A 500 ( 3.3A)	0.27A	1jr1B-5upyA: 49.9	1jr1B-5upyA: 30.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ME7_A_MOAA600_1 (INOSINE-5'-MONOPHOSP HATE DEHYDROGENASE)	5upy	INOSINE-5'-MONOPHOSP HATE DEHYDROGENASE (Listeria monocytogenes)	5 / 8	ASN A 280 ILE A 302 GLY A 303 CYH A 308 GLY A 392	IMP A 500 ( 4.3A) None None IMP A 500 (-3.2A) IMP A 500 ( 3.3A)	0.41A	1me7A-5upyA: 46.8	1me7A-5upyA: 27.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ME7_A_MOAA600_1 (INOSINE-5'-MONOPHOSP HATE DEHYDROGENASE)	5upy	INOSINE-5'-MONOPHOSP HATE DEHYDROGENASE (Listeria monocytogenes)	4 / 8	ASN A 280 ILE A 302 GLY A 303 GLY A 390	IMP A 500 ( 4.3A) None None IMP A 500 (-3.2A)	0.78A	1me7A-5upyA: 46.8	1me7A-5upyA: 27.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ME7_A_MOAA600_1 (INOSINE-5'-MONOPHOSP HATE DEHYDROGENASE)	5upy	INOSINE-5'-MONOPHOSP HATE DEHYDROGENASE (Listeria monocytogenes)	4 / 8	ASP A 251 ILE A 302 GLY A 303 CYH A 308	None None None IMP A 500 (-3.2A)	0.74A	1me7A-5upyA: 46.8	1me7A-5upyA: 27.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1OIP_A_VIVA1278_0 (ALPHA-TOCOPHEROL TRANSFER PROTEIN)	5upy	INOSINE-5'-MONOPHOSP HATE DEHYDROGENASE (Listeria monocytogenes)	5 / 12	ILE A 63 ILE A 338 ILE A 350 LEU A 354 ILE A 439	None	0.83A	1oipA-5upyA: undetectable	1oipA-5upyA: 21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1Q23_F_FUAF704_1 (CHLORAMPHENICOL ACETYLTRANSFERASE)	5upy	INOSINE-5'-MONOPHOSP HATE DEHYDROGENASE (Listeria monocytogenes)	5 / 11	THR A 446 SER A 448 LEU A 32 VAL A 436 VAL A 30	None	1.22A	1q23F-5upyA: undetectable	1q23F-5upyA: 18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1QHS_A_CLMA888_0 (PROTEIN (CHLORAMPHENICOL PHOSPHOTRANSFERASE))	5upy	INOSINE-5'-MONOPHOSP HATE DEHYDROGENASE (Listeria monocytogenes)	4 / 5	PRO A 374 LYS A 58 MET A 59 ALA A 62	None	1.29A	1qhsA-5upyA: undetectable	1qhsA-5upyA: 19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1QHY_A_CLMA888_0 (CHLORAMPHENICOL PHOSPHOTRANSFERASE)	5upy	INOSINE-5'-MONOPHOSP HATE DEHYDROGENASE (Listeria monocytogenes)	4 / 6	PRO A 374 LYS A 58 MET A 59 ALA A 62	None	1.33A	1qhyA-5upyA: undetectable	1qhyA-5upyA: 19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SBR_B_VIBB503_1 (YKOF)	5upy	INOSINE-5'-MONOPHOSP HATE DEHYDROGENASE (Listeria monocytogenes)	4 / 7	ILE A 267 ILE A 264 LYS A 263 THR A 252	None	0.92A	1sbrB-5upyA: undetectable	1sbrB-5upyA: 19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2AQU_B_DR7B300_2 (HIV-1 PROTEASE)	5upy	INOSINE-5'-MONOPHOSP HATE DEHYDROGENASE (Listeria monocytogenes)	6 / 11	GLY A 279 ASP A 251 ILE A 248 ILE A 297 VAL A 293 ILE A 264	None	1.35A	2aquB-5upyA: undetectable	2aquB-5upyA: 15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2BR4_C_SAMC301_0 (CEPHALOSPORIN HYDROXYLASE CMCI)	5upy	INOSINE-5'-MONOPHOSP HATE DEHYDROGENASE (Listeria monocytogenes)	5 / 12	GLY A 301 ARG A 311 ASP A 326 CYH A 327 ASP A 341	None None None None IMP A 500 (-2.6A)	1.05A	2br4C-5upyA: undetectable	2br4C-5upyA: 20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2DRD_A_MIYA2001_1 (ACRB)	5upy	INOSINE-5'-MONOPHOSP HATE DEHYDROGENASE (Listeria monocytogenes)	5 / 9	GLY A 357 GLU A 456 ILE A 338 ALA A 340 VAL A 300	None	1.12A	2drdA-5upyA: undetectable	2drdA-5upyA: 17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QMM_A_SAMA301_0 (UPF0217 PROTEIN AF_1056)	5upy	INOSINE-5'-MONOPHOSP HATE DEHYDROGENASE (Listeria monocytogenes)	5 / 9	LEU A 363 ILE A 344 GLY A 343 GLY A 305 SER A 48	None None IMP A 500 (-3.6A) IMP A 500 (-3.4A) None	0.95A	2qmmA-5upyA: undetectable	2qmmA-5upyA: 21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QMM_B_SAMB301_0 (UPF0217 PROTEIN AF_1056)	5upy	INOSINE-5'-MONOPHOSP HATE DEHYDROGENASE (Listeria monocytogenes)	5 / 11	LEU A 363 ILE A 344 GLY A 343 GLY A 305 SER A 48	None None IMP A 500 (-3.6A) IMP A 500 (-3.4A) None	0.94A	2qmmA-5upyA: undetectable 2qmmB-5upyA: undetectable	2qmmA-5upyA: 21.04 2qmmB-5upyA: 21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2VE3_B_REAB1445_1 (PUTATIVE CYTOCHROME P450 120)	5upy	INOSINE-5'-MONOPHOSP HATE DEHYDROGENASE (Listeria monocytogenes)	5 / 12	ALA A 287 THR A 322 VAL A 318 GLY A 317 PRO A 304	None GOL A 503 (-2.6A) None None None	1.18A	2ve3B-5upyA: undetectable	2ve3B-5upyA: 21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3A51_A_VDYA6178_1 (VITAMIN D HYDROXYLASE)	5upy	INOSINE-5'-MONOPHOSP HATE DEHYDROGENASE (Listeria monocytogenes)	5 / 11	ILE A 46 ASN A 280 ILE A 344 PRO A 45 LEU A 354	None IMP A 500 ( 4.3A) None None None	1.24A	3a51A-5upyA: undetectable	3a51A-5upyA: 22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OGP_A_017A200_1 (FIV PROTEASE)	5upy	INOSINE-5'-MONOPHOSP HATE DEHYDROGENASE (Listeria monocytogenes)	5 / 9	GLY A 294 ASP A 296 ILE A 297 ILE A 267 LEU A 290	None GOL A 505 (-3.4A) None None None	0.95A	3ogpA-5upyA: undetectable	3ogpA-5upyA: 15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3UQ6_B_ADNB401_1 (ADENOSINE KINASE, PUTATIVE)	5upy	INOSINE-5'-MONOPHOSP HATE DEHYDROGENASE (Listeria monocytogenes)	5 / 12	ASP A 251 ILE A 339 GLY A 50 ALA A 49 VAL A 249	None None None IMP A 500 (-3.4A) None	0.90A	3uq6B-5upyA: undetectable	3uq6B-5upyA: 24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3VAQ_B_ADNB401_1 (PUTATIVE ADENOSINE KINASE)	5upy	INOSINE-5'-MONOPHOSP HATE DEHYDROGENASE (Listeria monocytogenes)	5 / 12	ASP A 251 ILE A 339 GLY A 50 ALA A 49 VAL A 249	None None None IMP A 500 (-3.4A) None	0.92A	3vaqB-5upyA: undetectable	3vaqB-5upyA: 24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4E3A_A_ADNA500_2 (SUGAR KINASE PROTEIN)	5upy	INOSINE-5'-MONOPHOSP HATE DEHYDROGENASE (Listeria monocytogenes)	4 / 4	SER A 306 TYR A 388 GLY A 342 PRO A 304	IMP A 500 (-2.6A) IMP A 500 (-4.6A) IMP A 500 ( 3.7A) None	1.46A	4e3aA-5upyA: undetectable	4e3aA-5upyA: 23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4E3A_A_ADNA500_2 (SUGAR KINASE PROTEIN)	5upy	INOSINE-5'-MONOPHOSP HATE DEHYDROGENASE (Listeria monocytogenes)	4 / 4	SER A 306 TYR A 388 GLY A 343 PRO A 304	IMP A 500 (-2.6A) IMP A 500 (-4.6A) IMP A 500 (-3.6A) None	1.30A	4e3aA-5upyA: undetectable	4e3aA-5upyA: 23.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4FO4_A_MOAA502_1 (INOSINE 5'-MONOPHOSPHATE DEHYDROGENASE)	5upy	INOSINE-5'-MONOPHOSP HATE DEHYDROGENASE (Listeria monocytogenes)	5 / 8	ASN A 280 CYH A 308 THR A 310 MET A 391 GLY A 392	IMP A 500 ( 4.3A) IMP A 500 (-3.2A) Q21 A 501 (-4.3A) None IMP A 500 ( 3.3A)	0.18A	4fo4A-5upyA: 56.0	4fo4A-5upyA: 62.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4FO4_A_MOAA502_1 (INOSINE 5'-MONOPHOSPHATE DEHYDROGENASE)	5upy	INOSINE-5'-MONOPHOSP HATE DEHYDROGENASE (Listeria monocytogenes)	5 / 8	ASP A 251 CYH A 308 THR A 310 MET A 391 GLY A 392	None IMP A 500 (-3.2A) Q21 A 501 (-4.3A) None IMP A 500 ( 3.3A)	0.83A	4fo4A-5upyA: 56.0	4fo4A-5upyA: 62.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4FO4_B_MOAB502_1 (INOSINE 5'-MONOPHOSPHATE DEHYDROGENASE)	5upy	INOSINE-5'-MONOPHOSP HATE DEHYDROGENASE (Listeria monocytogenes)	6 / 8	ASN A 280 GLY A 303 CYH A 308 THR A 310 MET A 391 GLY A 392	IMP A 500 ( 4.3A) None IMP A 500 (-3.2A) Q21 A 501 (-4.3A) None IMP A 500 ( 3.3A)	0.22A	4fo4B-5upyA: 52.7	4fo4B-5upyA: 62.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4FXS_A_MOAA702_1 (INOSINE-5'-MONOPHOSP HATE DEHYDROGENASE)	5upy	INOSINE-5'-MONOPHOSP HATE DEHYDROGENASE (Listeria monocytogenes)	7 / 9	ASP A 251 ASN A 280 ILE A 302 GLY A 303 CYH A 308 THR A 310 ASP A 341	None IMP A 500 ( 4.3A) None None IMP A 500 (-3.2A) Q21 A 501 (-4.3A) IMP A 500 (-2.6A)	0.33A	4fxsA-5upyA: 55.2	4fxsA-5upyA: 46.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EWU_A_BEZA1401_0 (MAGNESIUM-CHELATASE SUBUNIT CHLH, CHLOROPLASTIC)	5upy	INOSINE-5'-MONOPHOSP HATE DEHYDROGENASE (Listeria monocytogenes)	4 / 6	GLY A 444 SER A 23 VAL A 25 HIS A 453	None	1.07A	5ewuA-5upyA: undetectable	5ewuA-5upyA: 23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EWU_B_BEZB1401_0 (MAGNESIUM-CHELATASE SUBUNIT CHLH, CHLOROPLASTIC)	5upy	INOSINE-5'-MONOPHOSP HATE DEHYDROGENASE (Listeria monocytogenes)	4 / 6	GLY A 444 SER A 23 VAL A 25 HIS A 453	None	1.04A	5ewuB-5upyA: undetectable	5ewuB-5upyA: 23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5GWZ_D_010D6_0 (N-[(5-METHYLISOXAZOL -3-YL)CARBONYL]ALANY L-L-VALYL-N~1~-((1R, 2Z)-4-(BENZYLOXY)-4- OXO-1-{[(3R)-2-OXOPY RROLIDIN-3-YL]METHYL }BUT-2-ENYL)-L-LEUCI NAMIDE PEDV MAIN PROTEASE)	5upy	INOSINE-5'-MONOPHOSP HATE DEHYDROGENASE (Listeria monocytogenes)	3 / 3	MET A 391 HIS A 73 GLY A 400	None	0.85A	5gwzB-5upyA: undetectable	5gwzB-5upyA: 22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HWA_A_GCSA303_1 (CHITOSANASE)	5upy	INOSINE-5'-MONOPHOSP HATE DEHYDROGENASE (Listeria monocytogenes)	4 / 5	HIS A 73 VAL A 249 GLY A 70 ALA A 224	None	0.86A	5hwaA-5upyA: undetectable	5hwaA-5upyA: 21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5WWS_A_SAMA501_0 (PUTATIVE METHYLTRANSFERASE NSUN6)	5upy	INOSINE-5'-MONOPHOSP HATE DEHYDROGENASE (Listeria monocytogenes)	5 / 12	ALA A 49 GLY A 342 GLY A 68 LEU A 40 LEU A 42	IMP A 500 (-3.4A) IMP A 500 ( 3.7A) None None None	1.08A	5wwsA-5upyA: undetectable	5wwsA-5upyA: 24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5WZ1_A_SAMA601_0 (NS5 METHYLTRANSFERASE)	5upy	INOSINE-5'-MONOPHOSP HATE DEHYDROGENASE (Listeria monocytogenes)	5 / 12	GLY A 348 GLY A 444 GLY A 438 HIS A 453 ASP A 24	None	0.99A	5wz1A-5upyA: undetectable	5wz1A-5upyA: 23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5WZ1_C_SAMC601_0 (NS5 METHYLTRANSFERASE)	5upy	INOSINE-5'-MONOPHOSP HATE DEHYDROGENASE (Listeria monocytogenes)	5 / 12	GLY A 348 GLY A 444 GLY A 438 HIS A 453 ASP A 24	None	0.97A	5wz1C-5upyA: undetectable	5wz1C-5upyA: 23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5WZ1_D_SAMD601_0 (NS5 METHYLTRANSFERASE)	5upy	INOSINE-5'-MONOPHOSP HATE DEHYDROGENASE (Listeria monocytogenes)	5 / 12	GLY A 348 GLY A 444 GLY A 438 HIS A 453 ASP A 24	None	0.96A	5wz1D-5upyA: undetectable	5wz1D-5upyA: 23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5WZ1_E_SAME601_0 (NS5 METHYLTRANSFERASE)	5upy	INOSINE-5'-MONOPHOSP HATE DEHYDROGENASE (Listeria monocytogenes)	5 / 12	GLY A 348 GLY A 444 GLY A 438 HIS A 453 ASP A 24	None	0.97A	5wz1E-5upyA: undetectable	5wz1E-5upyA: 23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5WZ1_F_SAMF601_0 (NS5 METHYLTRANSFERASE)	5upy	INOSINE-5'-MONOPHOSP HATE DEHYDROGENASE (Listeria monocytogenes)	5 / 12	GLY A 348 GLY A 444 GLY A 438 HIS A 453 ASP A 24	None	0.97A	5wz1F-5upyA: undetectable	5wz1F-5upyA: 23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5WZ1_G_SAMG601_0 (NS5 METHYLTRANSFERASE)	5upy	INOSINE-5'-MONOPHOSP HATE DEHYDROGENASE (Listeria monocytogenes)	5 / 12	GLY A 348 GLY A 444 GLY A 438 HIS A 453 ASP A 24	None	0.98A	5wz1G-5upyA: undetectable	5wz1G-5upyA: 23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5WZ1_H_SAMH601_0 (NS5 METHYLTRANSFERASE)	5upy	INOSINE-5'-MONOPHOSP HATE DEHYDROGENASE (Listeria monocytogenes)	5 / 12	GLY A 348 GLY A 444 GLY A 438 HIS A 453 ASP A 24	None	0.95A	5wz1H-5upyA: undetectable	5wz1H-5upyA: 23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6AWP_A_FVXA701_1 (SODIUM-DEPENDENT SEROTONIN TRANSPORTER)	5upy	INOSINE-5'-MONOPHOSP HATE DEHYDROGENASE (Listeria monocytogenes)	5 / 9	ASP A 341 ASN A 280 ILE A 54 GLY A 70 THR A 53	IMP A 500 (-2.6A) IMP A 500 ( 4.3A) None None None	1.42A	6awpA-5upyA: undetectable	6awpA-5upyA: 23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6HLO_A_GBQA1501_1 (SUBSTANCE-P RECEPTOR,GLGA GLYCOGEN SYNTHASE,SUBSTANCE-P RECEPTOR)	5upy	INOSINE-5'-MONOPHOSP HATE DEHYDROGENASE (Listeria monocytogenes)	5 / 9	ILE A 248 ILE A 250 GLU A 242 VAL A 274 ILE A 276	None None None CL A 502 ( 4.4A) None	1.35A	6hloA-5upyA: undetectable	6hloA-5upyA: 21.79

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1E7B_A_HLTA4002_1","SERUM ALBUMIN","5upy","INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE","Listeria monocytogenes",4,"ARG A 288;ALA A 287;ALA A 331;GLU A 333","None","1.15A","1e7bA-5upyA:undetectable","1e7bA-5upyA:18.97"],["1E7B_B_HLTB4002_1","SERUM ALBUMIN","5upy","INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE","Listeria monocytogenes",4,"ARG A 288;ALA A 287;ALA A 331;GLU A 333","None","1.15A","1e7bB-5upyA:undetectable","1e7bB-5upyA:18.97"],["1E7C_A_HLTA4002_1","SERUM ALBUMIN","5upy","INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE","Listeria monocytogenes",4,"ARG A 288;ALA A 287;ALA A 331;GLU A 333","None","1.21A","1e7cA-5upyA:undetectable","1e7cA-5upyA:18.97"],["1JR1_A_MOAA1332_1","INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE 2","5upy","INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE","Listeria monocytogenes",5,"ASN A 280;GLY A 303;CYH A 308;THR A 310;GLY A 392","IMP A 500 ( 4.3A);None;IMP A 500 (-3.2A);Q21 A 501 (-4.3A);IMP A 500 ( 3.3A)","0.42A","1jr1A-5upyA:50.0","1jr1A-5upyA:30.30"],["1JR1_A_MOAA1332_1","INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE 2","5upy","INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE","Listeria monocytogenes",5,"ASP A 251;ASN A 280;GLY A 303;CYH A 308;THR A 310","None;IMP A 500 ( 4.3A);None;IMP A 500 (-3.2A);Q21 A 501 (-4.3A)","0.78A","1jr1A-5upyA:50.0","1jr1A-5upyA:30.30"],["1JR1_B_MOAB1333_1","INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE 2","5upy","INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE","Listeria monocytogenes",4,"ASN A 280;GLY A 303;THR A 310;GLY A 392","IMP A 500 ( 4.3A);None;Q21 A 501 (-4.3A);IMP A 500 ( 3.3A)","0.27A","1jr1B-5upyA:49.9","1jr1B-5upyA:30.30"],["1ME7_A_MOAA600_1","INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE","5upy","INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE","Listeria monocytogenes",5,"ASN A 280;ILE A 302;GLY A 303;CYH A 308;GLY A 392","IMP A 500 ( 4.3A);None;None;IMP A 500 (-3.2A);IMP A 500 ( 3.3A)","0.41A","1me7A-5upyA:46.8","1me7A-5upyA:27.54"],["1ME7_A_MOAA600_1","INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE","5upy","INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE","Listeria monocytogenes",4,"ASN A 280;ILE A 302;GLY A 303;GLY A 390","IMP A 500 ( 4.3A);None;None;IMP A 500 (-3.2A)","0.78A","1me7A-5upyA:46.8","1me7A-5upyA:27.54"],["1ME7_A_MOAA600_1","INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE","5upy","INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE","Listeria monocytogenes",4,"ASP A 251;ILE A 302;GLY A 303;CYH A 308","None;None;None;IMP A 500 (-3.2A)","0.74A","1me7A-5upyA:46.8","1me7A-5upyA:27.54"],["1OIP_A_VIVA1278_0","ALPHA-TOCOPHEROL TRANSFER PROTEIN","5upy","INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE","Listeria monocytogenes",5,"ILE A  63;ILE A 338;ILE A 350;LEU A 354;ILE A 439","None","0.83A","1oipA-5upyA:undetectable","1oipA-5upyA:21.47"],["1Q23_F_FUAF704_1","CHLORAMPHENICOL ACETYLTRANSFERASE","5upy","INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE","Listeria monocytogenes",5,"THR A 446;SER A 448;LEU A  32;VAL A 436;VAL A  30","None","1.22A","1q23F-5upyA:undetectable","1q23F-5upyA:18.46"],["1QHS_A_CLMA888_0","PROTEIN (CHLORAMPHENICOL PHOSPHOTRANSFERASE)","5upy","INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE","Listeria monocytogenes",4,"PRO A 374;LYS A  58;MET A  59;ALA A  62","None","1.29A","1qhsA-5upyA:undetectable","1qhsA-5upyA:19.78"],["1QHY_A_CLMA888_0","CHLORAMPHENICOL PHOSPHOTRANSFERASE","5upy","INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE","Listeria monocytogenes",4,"PRO A 374;LYS A  58;MET A  59;ALA A  62","None","1.33A","1qhyA-5upyA:undetectable","1qhyA-5upyA:19.78"],["1SBR_B_VIBB503_1","YKOF","5upy","INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE","Listeria monocytogenes",4,"ILE A 267;ILE A 264;LYS A 263;THR A 252","None","0.92A","1sbrB-5upyA:undetectable","1sbrB-5upyA:19.35"],["2AQU_B_DR7B300_2","HIV-1 PROTEASE","5upy","INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE","Listeria monocytogenes",6,"GLY A 279;ASP A 251;ILE A 248;ILE A 297;VAL A 293;ILE A 264","None","1.35A","2aquB-5upyA:undetectable","2aquB-5upyA:15.24"],["2BR4_C_SAMC301_0","CEPHALOSPORIN HYDROXYLASE CMCI","5upy","INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE","Listeria monocytogenes",5,"GLY A 301;ARG A 311;ASP A 326;CYH A 327;ASP A 341","None;None;None;None;IMP A 500 (-2.6A)","1.05A","2br4C-5upyA:undetectable","2br4C-5upyA:20.00"],["2DRD_A_MIYA2001_1","ACRB","5upy","INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE","Listeria monocytogenes",5,"GLY A 357;GLU A 456;ILE A 338;ALA A 340;VAL A 300","None","1.12A","2drdA-5upyA:undetectable","2drdA-5upyA:17.26"],["2QMM_A_SAMA301_0","UPF0217 PROTEIN AF_1056","5upy","INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE","Listeria monocytogenes",5,"LEU A 363;ILE A 344;GLY A 343;GLY A 305;SER A  48","None;None;IMP A 500 (-3.6A);IMP A 500 (-3.4A);None","0.95A","2qmmA-5upyA:undetectable","2qmmA-5upyA:21.04"],["2QMM_B_SAMB301_0","UPF0217 PROTEIN AF_1056","5upy","INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE","Listeria monocytogenes",5,"LEU A 363;ILE A 344;GLY A 343;GLY A 305;SER A  48","None;None;IMP A 500 (-3.6A);IMP A 500 (-3.4A);None","0.94A","2qmmA-5upyA:undetectable;2qmmB-5upyA:undetectable","2qmmA-5upyA:21.04;2qmmB-5upyA:21.04"],["2VE3_B_REAB1445_1","PUTATIVE CYTOCHROME P450 120","5upy","INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE","Listeria monocytogenes",5,"ALA A 287;THR A 322;VAL A 318;GLY A 317;PRO A 304","None;GOL A 503 (-2.6A);None;None;None","1.18A","2ve3B-5upyA:undetectable","2ve3B-5upyA:21.09"],["3A51_A_VDYA6178_1","VITAMIN D HYDROXYLASE","5upy","INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE","Listeria monocytogenes",5,"ILE A  46;ASN A 280;ILE A 344;PRO A  45;LEU A 354","None;IMP A 500 ( 4.3A);None;None;None","1.24A","3a51A-5upyA:undetectable","3a51A-5upyA:22.76"],["3OGP_A_017A200_1","FIV PROTEASE","5upy","INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE","Listeria monocytogenes",5,"GLY A 294;ASP A 296;ILE A 297;ILE A 267;LEU A 290","None;GOL A 505 (-3.4A);None;None;None","0.95A","3ogpA-5upyA:undetectable","3ogpA-5upyA:15.84"],["3UQ6_B_ADNB401_1","ADENOSINE KINASE, PUTATIVE","5upy","INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE","Listeria monocytogenes",5,"ASP A 251;ILE A 339;GLY A  50;ALA A  49;VAL A 249","None;None;None;IMP A 500 (-3.4A);None","0.90A","3uq6B-5upyA:undetectable","3uq6B-5upyA:24.30"],["3VAQ_B_ADNB401_1","PUTATIVE ADENOSINE KINASE","5upy","INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE","Listeria monocytogenes",5,"ASP A 251;ILE A 339;GLY A  50;ALA A  49;VAL A 249","None;None;None;IMP A 500 (-3.4A);None","0.92A","3vaqB-5upyA:undetectable","3vaqB-5upyA:24.30"],["4E3A_A_ADNA500_2","SUGAR KINASE PROTEIN","5upy","INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE","Listeria monocytogenes",4,"SER A 306;TYR A 388;GLY A 342;PRO A 304","IMP A 500 (-2.6A);IMP A 500 (-4.6A);IMP A 500 ( 3.7A);None","1.46A","4e3aA-5upyA:undetectable","4e3aA-5upyA:23.37"],["4E3A_A_ADNA500_2","SUGAR KINASE PROTEIN","5upy","INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE","Listeria monocytogenes",4,"SER A 306;TYR A 388;GLY A 343;PRO A 304","IMP A 500 (-2.6A);IMP A 500 (-4.6A);IMP A 500 (-3.6A);None","1.30A","4e3aA-5upyA:undetectable","4e3aA-5upyA:23.37"],["4FO4_A_MOAA502_1","INOSINE 5'-MONOPHOSPHATE DEHYDROGENASE","5upy","INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE","Listeria monocytogenes",5,"ASN A 280;CYH A 308;THR A 310;MET A 391;GLY A 392","IMP A 500 ( 4.3A);IMP A 500 (-3.2A);Q21 A 501 (-4.3A);None;IMP A 500 ( 3.3A)","0.18A","4fo4A-5upyA:56.0","4fo4A-5upyA:62.02"],["4FO4_A_MOAA502_1","INOSINE 5'-MONOPHOSPHATE DEHYDROGENASE","5upy","INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE","Listeria monocytogenes",5,"ASP A 251;CYH A 308;THR A 310;MET A 391;GLY A 392","None;IMP A 500 (-3.2A);Q21 A 501 (-4.3A);None;IMP A 500 ( 3.3A)","0.83A","4fo4A-5upyA:56.0","4fo4A-5upyA:62.02"],["4FO4_B_MOAB502_1","INOSINE 5'-MONOPHOSPHATE DEHYDROGENASE","5upy","INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE","Listeria monocytogenes",6,"ASN A 280;GLY A 303;CYH A 308;THR A 310;MET A 391;GLY A 392","IMP A 500 ( 4.3A);None;IMP A 500 (-3.2A);Q21 A 501 (-4.3A);None;IMP A 500 ( 3.3A)","0.22A","4fo4B-5upyA:52.7","4fo4B-5upyA:62.02"],["4FXS_A_MOAA702_1","INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE","5upy","INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE","Listeria monocytogenes",7,"ASP A 251;ASN A 280;ILE A 302;GLY A 303;CYH A 308;THR A 310;ASP A 341","None;IMP A 500 ( 4.3A);None;None;IMP A 500 (-3.2A);Q21 A 501 (-4.3A);IMP A 500 (-2.6A)","0.33A","4fxsA-5upyA:55.2","4fxsA-5upyA:46.83"],["5EWU_A_BEZA1401_0","MAGNESIUM-CHELATASE SUBUNIT CHLH, CHLOROPLASTIC","5upy","INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE","Listeria monocytogenes",4,"GLY A 444;SER A  23;VAL A  25;HIS A 453","None","1.07A","5ewuA-5upyA:undetectable","5ewuA-5upyA:23.86"],["5EWU_B_BEZB1401_0","MAGNESIUM-CHELATASE SUBUNIT CHLH, CHLOROPLASTIC","5upy","INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE","Listeria monocytogenes",4,"GLY A 444;SER A  23;VAL A  25;HIS A 453","None","1.04A","5ewuB-5upyA:undetectable","5ewuB-5upyA:23.86"],["5GWZ_D_010D6_0","N-[(5-METHYLISOXAZOL-3-YL)CARBONYL]ALANYL-L-VALYL-N~1~-((1R,2Z)-4-(BENZYLOXY)-4-OXO-1-{[(3R)-2-OXOPYRROLIDIN-3-YL]METHYL}BUT-2-ENYL)-L-LEUCINAMIDE;PEDV MAIN PROTEASE","5upy","INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE","Listeria monocytogenes",3,"MET A 391;HIS A  73;GLY A 400","None","0.85A","5gwzB-5upyA:undetectable","5gwzB-5upyA:22.90"],["5HWA_A_GCSA303_1","CHITOSANASE","5upy","INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE","Listeria monocytogenes",4,"HIS A  73;VAL A 249;GLY A  70;ALA A 224","None","0.86A","5hwaA-5upyA:undetectable","5hwaA-5upyA:21.33"],["5WWS_A_SAMA501_0","PUTATIVE METHYLTRANSFERASE NSUN6","5upy","INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE","Listeria monocytogenes",5,"ALA A  49;GLY A 342;GLY A  68;LEU A  40;LEU A  42","IMP A 500 (-3.4A);IMP A 500 ( 3.7A);None;None;None","1.08A","5wwsA-5upyA:undetectable","5wwsA-5upyA:24.16"],["5WZ1_A_SAMA601_0","NS5 METHYLTRANSFERASE","5upy","INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE","Listeria monocytogenes",5,"GLY A 348;GLY A 444;GLY A 438;HIS A 453;ASP A  24","None","0.99A","5wz1A-5upyA:undetectable","5wz1A-5upyA:23.34"],["5WZ1_C_SAMC601_0","NS5 METHYLTRANSFERASE","5upy","INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE","Listeria monocytogenes",5,"GLY A 348;GLY A 444;GLY A 438;HIS A 453;ASP A  24","None","0.97A","5wz1C-5upyA:undetectable","5wz1C-5upyA:23.34"],["5WZ1_D_SAMD601_0","NS5 METHYLTRANSFERASE","5upy","INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE","Listeria monocytogenes",5,"GLY A 348;GLY A 444;GLY A 438;HIS A 453;ASP A  24","None","0.96A","5wz1D-5upyA:undetectable","5wz1D-5upyA:23.34"],["5WZ1_E_SAME601_0","NS5 METHYLTRANSFERASE","5upy","INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE","Listeria monocytogenes",5,"GLY A 348;GLY A 444;GLY A 438;HIS A 453;ASP A  24","None","0.97A","5wz1E-5upyA:undetectable","5wz1E-5upyA:23.34"],["5WZ1_F_SAMF601_0","NS5 METHYLTRANSFERASE","5upy","INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE","Listeria monocytogenes",5,"GLY A 348;GLY A 444;GLY A 438;HIS A 453;ASP A  24","None","0.97A","5wz1F-5upyA:undetectable","5wz1F-5upyA:23.34"],["5WZ1_G_SAMG601_0","NS5 METHYLTRANSFERASE","5upy","INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE","Listeria monocytogenes",5,"GLY A 348;GLY A 444;GLY A 438;HIS A 453;ASP A  24","None","0.98A","5wz1G-5upyA:undetectable","5wz1G-5upyA:23.34"],["5WZ1_H_SAMH601_0","NS5 METHYLTRANSFERASE","5upy","INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE","Listeria monocytogenes",5,"GLY A 348;GLY A 444;GLY A 438;HIS A 453;ASP A  24","None","0.95A","5wz1H-5upyA:undetectable","5wz1H-5upyA:23.34"],["6AWP_A_FVXA701_1","SODIUM-DEPENDENT SEROTONIN TRANSPORTER","5upy","INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE","Listeria monocytogenes",5,"ASP A 341;ASN A 280;ILE A  54;GLY A  70;THR A  53","IMP A 500 (-2.6A);IMP A 500 ( 4.3A);None;None;None","1.42A","6awpA-5upyA:undetectable","6awpA-5upyA:23.53"],["6HLO_A_GBQA1501_1","SUBSTANCE-P RECEPTOR,GLGA GLYCOGEN SYNTHASE,SUBSTANCE-P RECEPTOR","5upy","INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE","Listeria monocytogenes",5,"ILE A 248;ILE A 250;GLU A 242;VAL A 274;ILE A 276","None;None;None; CL A 502 ( 4.4A);None","1.35A","6hloA-5upyA:undetectable","6hloA-5upyA:21.79"]]