SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5uqc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA8_0
(GRAMICIDIN A)		 5uqc DIHYDROPYRIMIDINASE-
RELATED PROTEIN 2
(Mus
musculus) 		3 / 3 VAL A 364
TRP A 366
TRP A 412
 None
 1.40A 1c4dA-5uqcA:
undetectable
1c4dB-5uqcA:
undetectable		 1c4dA-5uqcA:
6.01
1c4dB-5uqcA:
6.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R9O_A_FLPA501_1
(CYTOCHROME P450 2C9)		 5uqc DIHYDROPYRIMIDINASE-
RELATED PROTEIN 2
(Mus
musculus) 		5 / 12 VAL A 255
ILE A 240
MET A 168
ALA A 260
LEU A 326
 None
 0.96A 1r9oA-5uqcA:
undetectable		 1r9oA-5uqcA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 5uqc DIHYDROPYRIMIDINASE-
RELATED PROTEIN 2
(Mus
musculus) 		3 / 3 ASP A 190
LYS A 483
ARG A 487
 None
 0.85A 1ra8A-5uqcA:
undetectable		 1ra8A-5uqcA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDV_B_MK1B902_2
(PROTEASE RETROPEPSIN)		 5uqc DIHYDROPYRIMIDINASE-
RELATED PROTEIN 2
(Mus
musculus) 		6 / 11 GLY A  46
ALA A  33
ASP A  34
VAL A  65
ILE A  19
ILE A  24
 None
 1.32A 1sdvB-5uqcA:
undetectable		 1sdvB-5uqcA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVO_B_MK1B902_2
(POL POLYPROTEIN)		 5uqc DIHYDROPYRIMIDINASE-
RELATED PROTEIN 2
(Mus
musculus) 		6 / 12 GLY A  46
ALA A  33
ASP A  34
VAL A  65
ILE A  19
ILE A  24
 None
 1.30A 2avoB-5uqcA:
undetectable		 2avoB-5uqcA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BPX_B_MK1B902_2
(HIV-1 PROTEASE)		 5uqc DIHYDROPYRIMIDINASE-
RELATED PROTEIN 2
(Mus
musculus) 		6 / 12 GLY A  46
ALA A  33
ASP A  34
ILE A  19
PRO A  67
ILE A  24
 None
 1.48A 2bpxB-5uqcA:
undetectable		 2bpxB-5uqcA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BPX_B_MK1B902_2
(HIV-1 PROTEASE)		 5uqc DIHYDROPYRIMIDINASE-
RELATED PROTEIN 2
(Mus
musculus) 		6 / 12 GLY A  46
ALA A  33
ASP A  34
VAL A  65
ILE A  19
ILE A  24
 None
 1.32A 2bpxB-5uqcA:
undetectable		 2bpxB-5uqcA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_B_CHDB2_0
(LIVER
CARBOXYLESTERASE 1)		 5uqc DIHYDROPYRIMIDINASE-
RELATED PROTEIN 2
(Mus
musculus) 		3 / 3 TRP A 412
LYS A  23
PRO A 414
 None
 1.38A 2dqyB-5uqcA:
undetectable		 2dqyB-5uqcA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XNR_A_ACTA1001_0
(NUCLEAR
POLYADENYLATED
RNA-BINDING PROTEIN
3)		 5uqc DIHYDROPYRIMIDINASE-
RELATED PROTEIN 2
(Mus
musculus) 		3 / 3 SER A 465
ARG A 467
GLN A 449
 None
 0.90A 2xnrA-5uqcA:
undetectable		 2xnrA-5uqcA:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_A_SALA1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5uqc DIHYDROPYRIMIDINASE-
RELATED PROTEIN 2
(Mus
musculus) 		5 / 9 THR A 280
ILE A 279
GLY A 330
GLY A 357
ARG A  75
 None
 1.50A 2y7wA-5uqcA:
undetectable		 2y7wA-5uqcA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3Y_A_OBNA6000_1
(NA, K-ATPASE ALPHA
SUBUNIT)		 5uqc DIHYDROPYRIMIDINASE-
RELATED PROTEIN 2
(Mus
musculus) 		5 / 10 GLU A 435
GLY A 357
ALA A 332
PHE A 301
LEU A 307
 None
 1.21A 3a3yA-5uqcA:
undetectable		 3a3yA-5uqcA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX7_B_SALB1336_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5uqc DIHYDROPYRIMIDINASE-
RELATED PROTEIN 2
(Mus
musculus) 		5 / 9 GLU A 232
SER A 308
THR A 313
ALA A 260
ALA A 261
 None
 1.47A 3ax7B-5uqcA:
undetectable		 3ax7B-5uqcA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D9L_A_ACTA501_0
(CTD-PEPTIDE
RNA-BINDING PROTEIN
16)		 5uqc DIHYDROPYRIMIDINASE-
RELATED PROTEIN 2
(Mus
musculus) 		4 / 5 ILE A 469
PRO A 470
TYR A 468
TYR A 135
 None
 1.25A 3d9lA-5uqcA:
undetectable
3d9lY-5uqcA:
undetectable		 3d9lA-5uqcA:
14.29
3d9lY-5uqcA:
2.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_1
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 5uqc DIHYDROPYRIMIDINASE-
RELATED PROTEIN 2
(Mus
musculus) 		3 / 3 ARG A 227
ASP A 172
GLN A 180
 None
 0.91A 3lcvB-5uqcA:
undetectable		 3lcvB-5uqcA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5uqc DIHYDROPYRIMIDINASE-
RELATED PROTEIN 2
(Mus
musculus) 		4 / 6 GLU A 232
THR A 313
ALA A 260
ALA A 261
 None
 1.25A 3ns1C-5uqcA:
undetectable		 3ns1C-5uqcA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 5uqc DIHYDROPYRIMIDINASE-
RELATED PROTEIN 2
(Mus
musculus) 		4 / 5 PHE A 380
GLY A  99
ILE A  66
VAL A 410
 None
 0.79A 3wrkA-5uqcA:
undetectable		 3wrkA-5uqcA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_F_FOLF703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5uqc DIHYDROPYRIMIDINASE-
RELATED PROTEIN 2
(Mus
musculus) 		5 / 9 ALA A  96
SER A 136
PHE A 392
LEU A 394
THR A  93
 None
 1.31A 4eilF-5uqcA:
undetectable		 4eilF-5uqcA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K88_A_HFGA602_0
(PROLINE--TRNA LIGASE)		 5uqc DIHYDROPYRIMIDINASE-
RELATED PROTEIN 2
(Mus
musculus) 		5 / 12 VAL A 453
THR A 101
PHE A  76
HIS A 333
SER A 331
 None
 1.37A 4k88A-5uqcA:
undetectable		 4k88A-5uqcA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5uqc DIHYDROPYRIMIDINASE-
RELATED PROTEIN 2
(Mus
musculus) 		5 / 11 ALA A  96
SER A 136
PHE A 392
LEU A 394
THR A  93
 None
 1.24A 4kyaA-5uqcA:
undetectable		 4kyaA-5uqcA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5uqc DIHYDROPYRIMIDINASE-
RELATED PROTEIN 2
(Mus
musculus) 		5 / 12 ALA A  96
SER A 136
PHE A 392
LEU A 394
THR A  93
 None
 1.24A 4kyaB-5uqcA:
undetectable		 4kyaB-5uqcA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_D_FOLD703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5uqc DIHYDROPYRIMIDINASE-
RELATED PROTEIN 2
(Mus
musculus) 		5 / 12 ALA A  96
SER A 136
PHE A 392
LEU A 394
THR A  93
 None
 1.26A 4kyaD-5uqcA:
undetectable		 4kyaD-5uqcA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_F_FOLF703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5uqc DIHYDROPYRIMIDINASE-
RELATED PROTEIN 2
(Mus
musculus) 		5 / 12 ALA A  96
SER A 136
PHE A 392
LEU A 394
THR A  93
 None
 1.26A 4kyaF-5uqcA:
undetectable		 4kyaF-5uqcA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_H_FOLH703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5uqc DIHYDROPYRIMIDINASE-
RELATED PROTEIN 2
(Mus
musculus) 		5 / 12 ALA A  96
SER A 136
PHE A 392
LEU A 394
THR A  93
 None
 1.28A 4kyaH-5uqcA:
undetectable		 4kyaH-5uqcA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_1
(PROLINE--TRNA LIGASE)		 5uqc DIHYDROPYRIMIDINASE-
RELATED PROTEIN 2
(Mus
musculus) 		3 / 3 GLU A 359
THR A 335
HIS A 333
 None
 0.85A 4q15A-5uqcA:
undetectable		 4q15A-5uqcA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_1
(PROLINE--TRNA LIGASE)		 5uqc DIHYDROPYRIMIDINASE-
RELATED PROTEIN 2
(Mus
musculus) 		3 / 3 GLU A 360
THR A 335
HIS A 333
 None
 0.58A 4q15A-5uqcA:
undetectable		 4q15A-5uqcA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_1
(PROLINE--TRNA LIGASE)		 5uqc DIHYDROPYRIMIDINASE-
RELATED PROTEIN 2
(Mus
musculus) 		3 / 3 GLU A 359
THR A 335
HIS A 333
 None
 0.85A 4q15B-5uqcA:
undetectable		 4q15B-5uqcA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_1
(PROLINE--TRNA LIGASE)		 5uqc DIHYDROPYRIMIDINASE-
RELATED PROTEIN 2
(Mus
musculus) 		3 / 3 GLU A 360
THR A 335
HIS A 333
 None
 0.58A 4q15B-5uqcA:
undetectable		 4q15B-5uqcA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U95_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 5uqc DIHYDROPYRIMIDINASE-
RELATED PROTEIN 2
(Mus
musculus) 		5 / 12 SER A 282
SER A 259
GLU A 229
ILE A 264
ALA A 267
 None
 1.15A 4u95B-5uqcA:
undetectable		 4u95B-5uqcA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_1
(PROLINE--TRNA LIGASE)		 5uqc DIHYDROPYRIMIDINASE-
RELATED PROTEIN 2
(Mus
musculus) 		3 / 3 GLU A 359
THR A 335
HIS A 333
 None
 0.79A 4ydqB-5uqcA:
undetectable		 4ydqB-5uqcA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_1
(PROLINE--TRNA LIGASE)		 5uqc DIHYDROPYRIMIDINASE-
RELATED PROTEIN 2
(Mus
musculus) 		3 / 3 GLU A 360
THR A 335
HIS A 333
 None
 0.57A 4ydqB-5uqcA:
undetectable		 4ydqB-5uqcA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ENT_C_MIYC901_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB)		 5uqc DIHYDROPYRIMIDINASE-
RELATED PROTEIN 2
(Mus
musculus) 		5 / 9 SER A 282
SER A 259
GLU A 229
ILE A 264
ALA A 267
 None
 1.12A 5entC-5uqcA:
undetectable		 5entC-5uqcA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5uqc DIHYDROPYRIMIDINASE-
RELATED PROTEIN 2
(Mus
musculus) 		4 / 7 ILE A 447
GLY A 450
PHE A  90
ASP A 134
 None
 1.00A 5hieA-5uqcA:
undetectable		 5hieA-5uqcA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OS7_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 5uqc DIHYDROPYRIMIDINASE-
RELATED PROTEIN 2
(Mus
musculus) 		3 / 3 HIS A 289
SER A 292
LYS A 297
 None
 1.34A 5os7A-5uqcA:
undetectable		 5os7A-5uqcA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_B_9SCB601_1
(SERUM ALBUMIN)		 5uqc DIHYDROPYRIMIDINASE-
RELATED PROTEIN 2
(Mus
musculus) 		4 / 6 ASN A  26
PHE A  31
LEU A 409
SER A 405
 None
 1.35A 6a7pB-5uqcA:
undetectable		 6a7pB-5uqcA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC607_0
(ALPHA-AMYLASE)		 5uqc DIHYDROPYRIMIDINASE-
RELATED PROTEIN 2
(Mus
musculus) 		4 / 6 ASP A 214
GLY A 219
PRO A 220
GLY A 222
 None
 0.71A 6ag0C-5uqcA:
6.1		 6ag0C-5uqcA:
9.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GMD_B_ACTB402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 5uqc DIHYDROPYRIMIDINASE-
RELATED PROTEIN 2
(Mus
musculus) 		3 / 3 HIS A 289
SER A 292
LYS A 297
 None
 1.34A 6gmdB-5uqcA:
undetectable		 6gmdB-5uqcA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H0G_E_Y70E502_0
(PROTEIN CEREBLON
ZINC FINGER PROTEIN
692)		 5uqc DIHYDROPYRIMIDINASE-
RELATED PROTEIN 2
(Mus
musculus) 		5 / 12 ASN A 426
GLU A 360
HIS A 425
PHE A  76
GLY A  99
 None
 1.49A 6h0gE-5uqcA:
undetectable
6h0gF-5uqcA:
undetectable		 6h0gE-5uqcA:
10.43
6h0gF-5uqcA:
5.10