SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5uqd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AKD_A_CAMA420_0
(CYTOCHROME P450CAM)		 5uqd DUMPY: SHORTER THAN
WILD-TYPE
(Caenorhabditis
elegans) 		5 / 11 PHE A1595
VAL A1292
GLY A1291
VAL A1591
VAL A1530
 AKG  A1701 (-3.8A)
None
None
None
None
 1.28A 1akdA-5uqdA:
undetectable		 1akdA-5uqdA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGQ_A_PCFA1275_0
(WNT INHIBITORY
FACTOR 1)		 5uqd DUMPY: SHORTER THAN
WILD-TYPE
(Caenorhabditis
elegans) 		6 / 12 LEU A1579
LEU A1383
PRO A1388
ILE A1386
PHE A1279
VAL A1530
 None
 1.28A 2ygqA-5uqdA:
undetectable		 2ygqA-5uqdA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_A_PNTA901_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 5uqd DUMPY: SHORTER THAN
WILD-TYPE
(Caenorhabditis
elegans) 		5 / 12 TRP A1606
GLY A1406
SER A1357
VAL A1359
ASN A1378
 None
PG0  A1703 ( 4.5A)
None
None
None
 1.48A 3hiiA-5uqdA:
undetectable		 3hiiA-5uqdA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_B_PNTB901_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 5uqd DUMPY: SHORTER THAN
WILD-TYPE
(Caenorhabditis
elegans) 		5 / 12 TRP A1606
GLY A1406
SER A1357
VAL A1359
ASN A1378
 None
PG0  A1703 ( 4.5A)
None
None
None
 1.47A 3hiiB-5uqdA:
undetectable		 3hiiB-5uqdA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IEO_A_AMJA300_0
(CARBONIC ANHYDRASE 2)		 5uqd DUMPY: SHORTER THAN
WILD-TYPE
(Caenorhabditis
elegans) 		4 / 4 ILE A1529
GLN A1594
VAL A1559
PHE A1531
 None
 1.38A 3ieoA-5uqdA:
undetectable		 3ieoA-5uqdA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 5uqd DUMPY: SHORTER THAN
WILD-TYPE
(Caenorhabditis
elegans) 		5 / 12 LEU A1227
ARG A1276
THR A1249
ILE A1251
LEU A1287
 None
PG0  A1704 (-3.8A)
None
None
None
 1.00A 3k2hA-5uqdA:
undetectable		 3k2hA-5uqdA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KCX_A_CQLA1_0
(HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR)		 5uqd DUMPY: SHORTER THAN
WILD-TYPE
(Caenorhabditis
elegans) 		5 / 10 THR A1449
HIS A1452
ASP A1454
LYS A1526
HIS A1593
 AKG  A1701 (-3.6A)
FE2  A1702 ( 3.3A)
FE2  A1702 (-2.6A)
AKG  A1701 (-3.6A)
FE2  A1702 ( 3.3A)
 0.53A 3kcxA-5uqdA:
13.9		 3kcxA-5uqdA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5uqd DUMPY: SHORTER THAN
WILD-TYPE
(Caenorhabditis
elegans) 		5 / 12 LEU A1227
ARG A1276
THR A1249
ILE A1251
LEU A1287
 None
PG0  A1704 (-3.8A)
None
None
None
 1.16A 3nrrA-5uqdA:
undetectable		 3nrrA-5uqdA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5uqd DUMPY: SHORTER THAN
WILD-TYPE
(Caenorhabditis
elegans) 		5 / 12 LEU A1227
ARG A1276
THR A1249
ILE A1251
LEU A1287
 None
PG0  A1704 (-3.8A)
None
None
None
 1.09A 3nrrB-5uqdA:
undetectable		 3nrrB-5uqdA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_A_SAMA500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5uqd DUMPY: SHORTER THAN
WILD-TYPE
(Caenorhabditis
elegans) 		3 / 3 HIS A1580
SER A1252
GLU A1294
 None
 0.91A 3s8pA-5uqdA:
undetectable		 3s8pA-5uqdA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		 5uqd DUMPY: SHORTER THAN
WILD-TYPE
(Caenorhabditis
elegans) 		4 / 7 ILE A1592
GLU A1527
LEU A1564
VAL A1559
 None
 0.82A 3ua5B-5uqdA:
undetectable		 3ua5B-5uqdA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 5uqd DUMPY: SHORTER THAN
WILD-TYPE
(Caenorhabditis
elegans) 		4 / 7 TYR A1574
ILE A1250
ILE A1290
ALA A1289
 None
 0.78A 4lv9B-5uqdA:
undetectable		 4lv9B-5uqdA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5uqd DUMPY: SHORTER THAN
WILD-TYPE
(Caenorhabditis
elegans) 		5 / 12 VAL A1528
LEU A1577
VAL A1292
GLY A1291
LEU A1587
 None
 1.13A 4rrwA-5uqdA:
undetectable		 4rrwA-5uqdA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5uqd DUMPY: SHORTER THAN
WILD-TYPE
(Caenorhabditis
elegans) 		5 / 12 VAL A1528
LEU A1577
VAL A1292
GLY A1291
LEU A1587
 None
 1.13A 4rrzA-5uqdA:
undetectable		 4rrzA-5uqdA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_1
(HYDG PROTEIN)		 5uqd DUMPY: SHORTER THAN
WILD-TYPE
(Caenorhabditis
elegans) 		3 / 3 GLU A1519
ARG A1522
GLN A1257
 None
 0.90A 4rtbA-5uqdA:
undetectable		 4rtbA-5uqdA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5uqd DUMPY: SHORTER THAN
WILD-TYPE
(Caenorhabditis
elegans) 		4 / 5 ILE A1408
PHE A1586
SER A1403
ASP A1454
 PG0  A1703 (-4.2A)
None
None
FE2  A1702 (-2.6A)
 1.32A 4rzvB-5uqdA:
undetectable		 4rzvB-5uqdA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_I_IPHI101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 5uqd DUMPY: SHORTER THAN
WILD-TYPE
(Caenorhabditis
elegans) 		4 / 6 VAL A1539
HIS A1542
LEU A1543
LEU A1564
 None
 0.98A 5hrqB-5uqdA:
undetectable
5hrqI-5uqdA:
undetectable
5hrqJ-5uqdA:
undetectable		 5hrqB-5uqdA:
4.20
5hrqI-5uqdA:
7.53
5hrqJ-5uqdA:
4.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5uqd DUMPY: SHORTER THAN
WILD-TYPE
(Caenorhabditis
elegans) 		5 / 12 ILE A1506
GLY A1505
PHE A1409
TYR A1335
ALA A1339
 None
 1.13A 5n0oA-5uqdA:
undetectable		 5n0oA-5uqdA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5uqd DUMPY: SHORTER THAN
WILD-TYPE
(Caenorhabditis
elegans) 		5 / 12 ILE A1506
GLY A1505
PHE A1409
TYR A1335
ALA A1339
 None
 1.13A 5n0oB-5uqdA:
undetectable		 5n0oB-5uqdA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5uqd DUMPY: SHORTER THAN
WILD-TYPE
(Caenorhabditis
elegans) 		5 / 12 ILE A1506
GLY A1505
PHE A1409
TYR A1335
ALA A1339
 None
 1.13A 5n0rA-5uqdA:
undetectable		 5n0rA-5uqdA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5uqd DUMPY: SHORTER THAN
WILD-TYPE
(Caenorhabditis
elegans) 		5 / 12 ILE A1506
GLY A1505
PHE A1409
TYR A1335
ALA A1339
 None
 1.15A 5n0wA-5uqdA:
undetectable		 5n0wA-5uqdA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5uqd DUMPY: SHORTER THAN
WILD-TYPE
(Caenorhabditis
elegans) 		5 / 12 ILE A1506
GLY A1505
PHE A1409
TYR A1335
ALA A1339
 None
 1.10A 5n0xA-5uqdA:
undetectable		 5n0xA-5uqdA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5uqd DUMPY: SHORTER THAN
WILD-TYPE
(Caenorhabditis
elegans) 		5 / 12 ILE A1506
GLY A1505
PHE A1409
TYR A1335
ALA A1339
 None
 1.12A 5n0xB-5uqdA:
undetectable		 5n0xB-5uqdA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F5U_A_CQNA610_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 5uqd DUMPY: SHORTER THAN
WILD-TYPE
(Caenorhabditis
elegans) 		5 / 10 VAL A1528
LEU A1579
LEU A1503
LEU A1587
THR A1449
 None
None
None
None
AKG  A1701 (-3.6A)
 0.87A 6f5uA-5uqdA:
undetectable
6f5uB-5uqdA:
undetectable		 6f5uA-5uqdA:
11.84
6f5uB-5uqdA:
12.62