SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5uqe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_C_ESTC353_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 5uqe GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 SER A 502
GLY A 262
GLY A 487
SER A 428
PHE A 282
 None
 1.24A 1fduC-5uqeA:
undetectable		 1fduC-5uqeA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 5uqe GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 PRO A 290
HIS A 306
GLY A 310
ASN A 331
GLY A 337
 None
 1.30A 1ffyA-5uqeA:
undetectable		 1ffyA-5uqeA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX8_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO)		 5uqe GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 PHE A 527
LEU A 521
LEU A 540
PRO A 542
ILE A 231
 None
 1.20A 1mx8A-5uqeA:
undetectable		 1mx8A-5uqeA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RU9_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 5uqe GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 9 ALA A 452
ASN A 298
LEU A 448
GLY A 438
PHE A 439
 None
 1.45A 1ru9H-5uqeA:
undetectable
1ru9L-5uqeA:
undetectable		 1ru9H-5uqeA:
18.58
1ru9L-5uqeA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUA_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 5uqe GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 ALA A 452
ASN A 298
LEU A 448
GLY A 438
PHE A 439
 None
 1.46A 1ruaH-5uqeA:
undetectable
1ruaL-5uqeA:
undetectable		 1ruaH-5uqeA:
18.58
1ruaL-5uqeA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5uqe GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 THR A 342
VAL A 358
SER A 419
GLY A 337
ILE A 391
 None
 1.39A 1xvaA-5uqeA:
undetectable		 1xvaA-5uqeA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1435_1
(CHITINASE)		 5uqe GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 TYR A 530
GLY A 464
PHE A 472
SER A 469
 None
 0.98A 2a3cA-5uqeA:
undetectable		 2a3cA-5uqeA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2434_1
(CHITINASE)		 5uqe GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 TYR A 530
GLY A 464
PHE A 472
SER A 469
 None
 0.98A 2a3cB-5uqeA:
undetectable		 2a3cB-5uqeA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_C_ACTC36_0
(GCN4 LEUCINE ZIPPER)		 5uqe GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 HIS A 591
ALA A 593
ALA A 595
GLU A 626
ALA A 594
 None
 1.12A 2r2vC-5uqeA:
undetectable
2r2vF-5uqeA:
undetectable
2r2vG-5uqeA:
undetectable		 2r2vC-5uqeA:
6.59
2r2vF-5uqeA:
6.59
2r2vG-5uqeA:
6.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 5uqe GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 GLY A 564
ALA A 593
VAL A 592
ASP A 565
VAL A 566
 None
 0.92A 2yvlB-5uqeA:
undetectable		 2yvlB-5uqeA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_D_SAMD603_0
(HYPOTHETICAL PROTEIN)		 5uqe GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 GLY A 564
ALA A 593
VAL A 592
ASP A 565
VAL A 566
 None
 0.94A 2yvlD-5uqeA:
undetectable		 2yvlD-5uqeA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_D_FLPD701_1
(CYCLOOXYGENASE-2)		 5uqe GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		6 / 12 VAL A 422
LEU A 284
VAL A 429
GLY A 367
ALA A 366
LEU A 362
 None
 1.41A 3pghD-5uqeA:
undetectable		 3pghD-5uqeA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 5uqe GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 CYH A 266
GLN A 271
ILE A 442
ASP A 172
 None
 1.20A 4z4cA-5uqeA:
undetectable		 4z4cA-5uqeA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5uqe GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		6 / 12 VAL A 422
LEU A 284
VAL A 429
GLY A 367
ALA A 366
LEU A 362
 None
 1.40A 5ikrB-5uqeA:
undetectable		 5ikrB-5uqeA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5uqe GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE A 488
GLY A 514
HIS A 516
PHE A 468
ALA A 480
 None
 1.06A 5n0oA-5uqeA:
undetectable		 5n0oA-5uqeA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5uqe GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE A 488
GLY A 514
HIS A 516
PHE A 468
ALA A 480
 None
 1.05A 5n0oB-5uqeA:
undetectable		 5n0oB-5uqeA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5uqe GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE A 488
GLY A 514
HIS A 516
PHE A 468
ALA A 480
 None
 1.04A 5n0rA-5uqeA:
undetectable		 5n0rA-5uqeA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5uqe GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE A 488
GLY A 514
HIS A 516
PHE A 468
ALA A 480
 None
 1.02A 5n0sA-5uqeA:
undetectable		 5n0sA-5uqeA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5uqe GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE A 488
GLY A 514
HIS A 516
PHE A 468
ALA A 480
 None
 1.04A 5n0tA-5uqeA:
undetectable		 5n0tA-5uqeA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5uqe GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE A 488
GLY A 514
HIS A 516
PHE A 468
ALA A 480
 None
 1.03A 5n0tB-5uqeA:
undetectable		 5n0tB-5uqeA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5uqe GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE A 488
GLY A 514
HIS A 516
PHE A 468
ALA A 480
 None
 1.06A 5n0wA-5uqeA:
undetectable		 5n0wA-5uqeA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5uqe GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE A 488
GLY A 514
HIS A 516
PHE A 468
ALA A 480
 None
 1.08A 5n0wB-5uqeA:
undetectable		 5n0wB-5uqeA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5uqe GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE A 488
GLY A 514
HIS A 516
PHE A 468
ALA A 480
 None
 1.06A 5n0xA-5uqeA:
undetectable		 5n0xA-5uqeA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5uqe GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE A 488
GLY A 514
HIS A 516
PHE A 468
ALA A 480
 None
 1.05A 5n0xB-5uqeA:
undetectable		 5n0xB-5uqeA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5uqe GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE A 488
GLY A 514
HIS A 516
PHE A 468
ALA A 480
 None
 1.09A 5n4iA-5uqeA:
undetectable		 5n4iA-5uqeA:
20.19