SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5uqi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GEB_A_CAMA418_0
(CYTOCHROME P450-CAM)		 5uqi PHOSPHOSUGAR
ISOMERASE
(Escherichia
coli) 		5 / 9 PHE A  48
THR A  70
LEU A 172
VAL A 168
ILE A  95
 None
 1.42A 1gebA-5uqiA:
undetectable		 1gebA-5uqiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHO_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5uqi PHOSPHOSUGAR
ISOMERASE
(Escherichia
coli) 		5 / 9 THR A 109
GLY A  77
GLY A  86
LEU A  85
GLY A  83
 None
 1.20A 1jhoA-5uqiA:
undetectable		 1jhoA-5uqiA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHR_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5uqi PHOSPHOSUGAR
ISOMERASE
(Escherichia
coli) 		5 / 9 THR A 109
GLY A  77
GLY A  86
LEU A  85
GLY A  83
 None
 1.23A 1jhrA-5uqiA:
undetectable		 1jhrA-5uqiA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHY_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5uqi PHOSPHOSUGAR
ISOMERASE
(Escherichia
coli) 		5 / 9 THR A 109
GLY A  77
GLY A  86
LEU A  85
GLY A  83
 None
 1.22A 1jhyA-5uqiA:
undetectable		 1jhyA-5uqiA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L4N_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5uqi PHOSPHOSUGAR
ISOMERASE
(Escherichia
coli) 		5 / 9 THR A 109
GLY A  77
GLY A  86
LEU A  85
GLY A  83
 None
 1.21A 1l4nA-5uqiA:
undetectable		 1l4nA-5uqiA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5K_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5uqi PHOSPHOSUGAR
ISOMERASE
(Escherichia
coli) 		5 / 9 THR A 109
GLY A  77
GLY A  86
LEU A  85
GLY A  83
 None
 1.19A 1l5kA-5uqiA:
undetectable		 1l5kA-5uqiA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5L_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5uqi PHOSPHOSUGAR
ISOMERASE
(Escherichia
coli) 		5 / 9 THR A 109
GLY A  77
GLY A  86
LEU A  85
GLY A  83
 None
 1.21A 1l5lA-5uqiA:
undetectable		 1l5lA-5uqiA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5M_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5uqi PHOSPHOSUGAR
ISOMERASE
(Escherichia
coli) 		5 / 9 THR A 109
GLY A  77
GLY A  86
LEU A  85
GLY A  83
 None
 1.20A 1l5mA-5uqiA:
undetectable		 1l5mA-5uqiA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGQ_A_PCFA1275_0
(WNT INHIBITORY
FACTOR 1)		 5uqi PHOSPHOSUGAR
ISOMERASE
(Escherichia
coli) 		5 / 12 LEU A 172
ILE A  36
ILE A 141
PRO A 142
VAL A  46
 None
 0.97A 2ygqA-5uqiA:
undetectable		 2ygqA-5uqiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A9E_B_REAB1_1
(RETINOIC ACID
RECEPTOR ALPHA)		 5uqi PHOSPHOSUGAR
ISOMERASE
(Escherichia
coli) 		5 / 11 PHE A  65
LEU A  35
ILE A  36
SER A  41
VAL A 161
 None
 1.10A 3a9eB-5uqiA:
undetectable		 3a9eB-5uqiA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 5uqi PHOSPHOSUGAR
ISOMERASE
(Escherichia
coli) 		5 / 12 PHE A 123
ILE A  97
LEU A 131
GLY A 101
ALA A 108
 None
 1.07A 4eb4A-5uqiA:
undetectable		 4eb4A-5uqiA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 5uqi PHOSPHOSUGAR
ISOMERASE
(Escherichia
coli) 		5 / 12 PHE A 123
ILE A  97
LEU A 131
GLY A 101
ALA A 108
 None
 1.13A 4eb4B-5uqiA:
undetectable		 4eb4B-5uqiA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQI_A_NIOA403_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5uqi PHOSPHOSUGAR
ISOMERASE
(Escherichia
coli) 		5 / 9 THR A 109
GLY A  77
GLY A  86
LEU A  85
GLY A  83
 None
 1.19A 4kqiA-5uqiA:
undetectable		 4kqiA-5uqiA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4C_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 5uqi PHOSPHOSUGAR
ISOMERASE
(Escherichia
coli) 		5 / 8 PHE A  48
THR A  70
LEU A 172
VAL A 168
ILE A  95
 None
 1.45A 4l4cB-5uqiA:
undetectable		 4l4cB-5uqiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5uqi PHOSPHOSUGAR
ISOMERASE
(Escherichia
coli) 		4 / 7 PHE A  65
SER A  72
ALA A  58
LEU A  61
 None
 1.01A 4xk8A-5uqiA:
undetectable		 4xk8A-5uqiA:
7.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_A_ILEA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 5uqi PHOSPHOSUGAR
ISOMERASE
(Escherichia
coli) 		4 / 6 ALA A 108
THR A 109
VAL A  81
VAL A  51
 None
 1.01A 5eclA-5uqiA:
undetectable		 5eclA-5uqiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 5uqi PHOSPHOSUGAR
ISOMERASE
(Escherichia
coli) 		3 / 3 VAL A  46
GLN A  40
CYH A  42
 None
 0.68A 5icxA-5uqiA:
undetectable
5icxE-5uqiA:
undetectable		 5icxA-5uqiA:
16.20
5icxE-5uqiA:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 5uqi PHOSPHOSUGAR
ISOMERASE
(Escherichia
coli) 		3 / 3 VAL A  46
GLN A  40
CYH A  42
 None
 0.91A 5icxC-5uqiA:
undetectable
5icxF-5uqiA:
undetectable		 5icxC-5uqiA:
16.20
5icxF-5uqiA:
8.75