SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5uqj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RV7_B_AB1B1001_1
(PROTEASE)		 5uqj U6 SNRNA
PHOSPHODIESTERASE
(Saccharomyces
cerevisiae) 		5 / 11 ALA A 235
ILE A 179
PRO A 191
THR A 244
VAL A 116
 None
 1.04A 1rv7A-5uqjA:
undetectable
1rv7B-5uqjA:
undetectable		 1rv7A-5uqjA:
17.73
1rv7B-5uqjA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 5uqj U6 SNRNA
PHOSPHODIESTERASE
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 188
PRO A 120
ALA A 235
ILE A 234
 None
 0.96A 2aofB-5uqjA:
undetectable		 2aofB-5uqjA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_0
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 5uqj U6 SNRNA
PHOSPHODIESTERASE
(Saccharomyces
cerevisiae) 		5 / 12 MET A 155
PHE A  81
ILE A 276
PHE A 151
GLU A 181
 None
 1.25A 3aocC-5uqjA:
undetectable		 3aocC-5uqjA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_A_URFA2001_1
(URIDINE
PHOSPHORYLASE)		 5uqj U6 SNRNA
PHOSPHODIESTERASE
(Saccharomyces
cerevisiae) 		5 / 10 THR A 254
GLY A 256
GLU A 253
LEU A 258
LEU A 259
 None
 1.08A 3kvrA-5uqjA:
undetectable		 3kvrA-5uqjA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 5uqj U6 SNRNA
PHOSPHODIESTERASE
(Saccharomyces
cerevisiae) 		5 / 10 THR A 254
GLY A 256
GLU A 253
LEU A 258
LEU A 259
 None
 1.14A 3kvrB-5uqjA:
undetectable		 3kvrB-5uqjA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_A_URFA400_1
(URIDINE
PHOSPHORYLASE 1)		 5uqj U6 SNRNA
PHOSPHODIESTERASE
(Saccharomyces
cerevisiae) 		5 / 9 THR A 254
GLY A 256
GLU A 253
LEU A 258
LEU A 259
 None
 1.10A 3nbqA-5uqjA:
undetectable		 3nbqA-5uqjA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_A_SAMA500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5uqj U6 SNRNA
PHOSPHODIESTERASE
(Saccharomyces
cerevisiae) 		3 / 3 HIS A 149
SER A  77
GLU A 280
 None
 0.56A 3s8pA-5uqjA:
undetectable		 3s8pA-5uqjA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_A_9PLA501_1
(CYTOCHROME P450 2A6)		 5uqj U6 SNRNA
PHOSPHODIESTERASE
(Saccharomyces
cerevisiae) 		5 / 11 PHE A 204
PHE A 289
ILE A 276
LEU A 169
PHE A 167
 None
 1.05A 3t3rA-5uqjA:
undetectable		 3t3rA-5uqjA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_C_9PLC501_1
(CYTOCHROME P450 2A6)		 5uqj U6 SNRNA
PHOSPHODIESTERASE
(Saccharomyces
cerevisiae) 		5 / 9 PHE A 204
VAL A 134
PHE A 289
ILE A 276
PHE A 167
 None
 1.16A 3t3rC-5uqjA:
undetectable		 3t3rC-5uqjA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4C_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 5uqj U6 SNRNA
PHOSPHODIESTERASE
(Saccharomyces
cerevisiae) 		4 / 8 PHE A 204
LEU A 169
VAL A 273
ILE A 164
 None
None
ACT  A 307 (-4.1A)
None
 1.01A 4l4cB-5uqjA:
undetectable		 4l4cB-5uqjA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 5uqj U6 SNRNA
PHOSPHODIESTERASE
(Saccharomyces
cerevisiae) 		4 / 6 SER A 284
HIS A 283
ARG A 286
TYR A 277
 None
None
ACT  A 307 (-3.5A)
None
 1.30A 5x7pA-5uqjA:
undetectable		 5x7pA-5uqjA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 5uqj U6 SNRNA
PHOSPHODIESTERASE
(Saccharomyces
cerevisiae) 		4 / 6 SER A 284
HIS A 283
ARG A 286
TYR A 277
 None
None
ACT  A 307 (-3.5A)
None
 1.34A 5x7pB-5uqjA:
undetectable		 5x7pB-5uqjA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Q_A_ACRA1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 5uqj U6 SNRNA
PHOSPHODIESTERASE
(Saccharomyces
cerevisiae) 		4 / 6 SER A 284
HIS A 283
ARG A 286
TYR A 277
 None
None
ACT  A 307 (-3.5A)
None
 1.30A 5x7qA-5uqjA:
undetectable		 5x7qA-5uqjA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Q_B_ACRB1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 5uqj U6 SNRNA
PHOSPHODIESTERASE
(Saccharomyces
cerevisiae) 		4 / 6 SER A 284
HIS A 283
ARG A 286
TYR A 277
 None
None
ACT  A 307 (-3.5A)
None
 1.34A 5x7qB-5uqjA:
undetectable		 5x7qB-5uqjA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7R_A_ACRA1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 5uqj U6 SNRNA
PHOSPHODIESTERASE
(Saccharomyces
cerevisiae) 		4 / 6 SER A 284
HIS A 283
ARG A 286
TYR A 277
 None
None
ACT  A 307 (-3.5A)
None
 1.31A 5x7rA-5uqjA:
undetectable		 5x7rA-5uqjA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7R_B_ACRB1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 5uqj U6 SNRNA
PHOSPHODIESTERASE
(Saccharomyces
cerevisiae) 		4 / 6 SER A 284
HIS A 283
ARG A 286
TYR A 277
 None
None
ACT  A 307 (-3.5A)
None
 1.33A 5x7rB-5uqjA:
undetectable		 5x7rB-5uqjA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 5uqj U6 SNRNA
PHOSPHODIESTERASE
(Saccharomyces
cerevisiae) 		4 / 7 ARG A 247
LEU A 177
ALA A 237
GLN A 250
 None
 1.25A 6b89A-5uqjA:
undetectable		 6b89A-5uqjA:
16.59