SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5uqr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_B_CFFB1863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5uqr 2-METHYLCITRATE
SYNTHASE,
MITOCHONDRIAL
(Aspergillus
fumigatus) 		4 / 6 ASN A 252
PHE A 255
GLY A 419
TYR A 418
 None
 1.09A 1l5qB-5uqrA:
undetectable		 1l5qB-5uqrA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_A_DOLA300_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		 5uqr 2-METHYLCITRATE
SYNTHASE,
MITOCHONDRIAL
(Aspergillus
fumigatus) 		5 / 11 ILE A 210
HIS A 305
PRO A 438
VAL A 407
ASP A 408
 None
OAA  A 501 (-4.4A)
None
None
None
 1.32A 1mrlA-5uqrA:
undetectable
1mrlB-5uqrA:
undetectable		 1mrlA-5uqrA:
15.71
1mrlB-5uqrA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_B_DOLB301_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		 5uqr 2-METHYLCITRATE
SYNTHASE,
MITOCHONDRIAL
(Aspergillus
fumigatus) 		5 / 12 ILE A 210
HIS A 305
PRO A 438
VAL A 407
ASP A 408
 None
OAA  A 501 (-4.4A)
None
None
None
 1.26A 1mrlB-5uqrA:
undetectable
1mrlC-5uqrA:
undetectable		 1mrlB-5uqrA:
15.71
1mrlC-5uqrA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_2
(ANGIOTENSIN
CONVERTING ENZYME)		 5uqr 2-METHYLCITRATE
SYNTHASE,
MITOCHONDRIAL
(Aspergillus
fumigatus) 		4 / 4 SER A 387
VAL A 332
PHE A 380
VAL A 413
 None
 1.39A 1o86A-5uqrA:
2.2		 1o86A-5uqrA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDT_A_VIAA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5uqr 2-METHYLCITRATE
SYNTHASE,
MITOCHONDRIAL
(Aspergillus
fumigatus) 		5 / 12 ALA A 175
ILE A 171
VAL A 213
ALA A 214
PHE A 159
 None
 1.31A 1udtA-5uqrA:
undetectable		 1udtA-5uqrA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA502_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 5uqr 2-METHYLCITRATE
SYNTHASE,
MITOCHONDRIAL
(Aspergillus
fumigatus) 		3 / 3 LEU A 123
HIS A  95
LYS A  97
 None
 1.07A 1y7iA-5uqrA:
undetectable		 1y7iA-5uqrA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B9E_A_SAMA1201_0
(NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2)		 5uqr 2-METHYLCITRATE
SYNTHASE,
MITOCHONDRIAL
(Aspergillus
fumigatus) 		5 / 12 GLY A 249
LEU A 258
ASP A 257
PHE A 420
SER A 238
 None
 0.96A 2b9eA-5uqrA:
undetectable		 2b9eA-5uqrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_B_SAMB1267_1
(NON-STRUCTURAL
PROTEIN 5)		 5uqr 2-METHYLCITRATE
SYNTHASE,
MITOCHONDRIAL
(Aspergillus
fumigatus) 		3 / 3 SER A 131
HIS A  95
ASP A 268
 None
 0.80A 2wa2B-5uqrA:
undetectable		 2wa2B-5uqrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 5uqr 2-METHYLCITRATE
SYNTHASE,
MITOCHONDRIAL
(Aspergillus
fumigatus) 		3 / 3 SER A  29
GLU A 141
ASP A 201
 None
 0.82A 2zulA-5uqrA:
undetectable		 2zulA-5uqrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDS_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5uqr 2-METHYLCITRATE
SYNTHASE,
MITOCHONDRIAL
(Aspergillus
fumigatus) 		4 / 6 ASN A 252
PHE A 255
GLY A 419
TYR A 418
 None
 1.08A 3ddsB-5uqrA:
undetectable		 3ddsB-5uqrA:
6.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDW_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5uqr 2-METHYLCITRATE
SYNTHASE,
MITOCHONDRIAL
(Aspergillus
fumigatus) 		4 / 6 ASN A 252
PHE A 255
GLY A 419
TYR A 418
 None
 1.09A 3ddwB-5uqrA:
undetectable		 3ddwB-5uqrA:
6.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 5uqr 2-METHYLCITRATE
SYNTHASE,
MITOCHONDRIAL
(Aspergillus
fumigatus) 		3 / 3 SER A  29
GLU A 141
ASP A 201
 None
 0.78A 3dmhA-5uqrA:
undetectable		 3dmhA-5uqrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 5uqr 2-METHYLCITRATE
SYNTHASE,
MITOCHONDRIAL
(Aspergillus
fumigatus) 		5 / 12 ALA A 309
LEU A 307
HIS A 266
ALA A 214
LEU A 245
 None
 1.35A 3tm4A-5uqrA:
undetectable		 3tm4A-5uqrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_C_08JC3_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5uqr 2-METHYLCITRATE
SYNTHASE,
MITOCHONDRIAL
(Aspergillus
fumigatus) 		4 / 8 PRO A 359
VAL A 407
LEU A 265
ILE A  92
 None
 0.90A 3u5kC-5uqrA:
undetectable		 3u5kC-5uqrA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WQW_A_GCSA502_1
(CHITINASE)		 5uqr 2-METHYLCITRATE
SYNTHASE,
MITOCHONDRIAL
(Aspergillus
fumigatus) 		4 / 5 TRP A 237
GLY A 267
ALA A 264
PHE A 138
 None
 0.99A 3wqwA-5uqrA:
undetectable		 3wqwA-5uqrA:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_B_SAMB1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 5uqr 2-METHYLCITRATE
SYNTHASE,
MITOCHONDRIAL
(Aspergillus
fumigatus) 		5 / 12 HIS A 266
GLY A 431
TYR A 293
GLY A 296
SER A 275
 None
None
None
None
OAA  A 501 ( 4.9A)
 1.20A 4blvB-5uqrA:
undetectable		 4blvB-5uqrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		 5uqr 2-METHYLCITRATE
SYNTHASE,
MITOCHONDRIAL
(Aspergillus
fumigatus) 		4 / 6 LEU A 300
LEU A 297
SER A 294
THR A 279
 None
 1.12A 4d7bB-5uqrA:
undetectable		 4d7bB-5uqrA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5uqr 2-METHYLCITRATE
SYNTHASE,
MITOCHONDRIAL
(Aspergillus
fumigatus) 		3 / 3 ARG A 434
TRP A  81
GLY A 271
 OAA  A 501 (-3.0A)
None
None
 0.69A 4e7cA-5uqrA:
undetectable		 4e7cA-5uqrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7A_A_MXDA1002_1
(ANDROGEN RECEPTOR)		 5uqr 2-METHYLCITRATE
SYNTHASE,
MITOCHONDRIAL
(Aspergillus
fumigatus) 		3 / 3 GLU A 118
TRP A 237
LYS A 108
 None
 1.38A 4k7aA-5uqrA:
undetectable		 4k7aA-5uqrA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5uqr 2-METHYLCITRATE
SYNTHASE,
MITOCHONDRIAL
(Aspergillus
fumigatus) 		4 / 5 SER A 146
ALA A 208
HIS A 147
LEU A 231
 None
 1.20A 5dzkb-5uqrA:
undetectable
5dzkp-5uqrA:
undetectable		 5dzkb-5uqrA:
undetectable
5dzkp-5uqrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5uqr 2-METHYLCITRATE
SYNTHASE,
MITOCHONDRIAL
(Aspergillus
fumigatus) 		4 / 8 SER A 146
ALA A 208
HIS A 147
LEU A 231
 None
 1.20A 5dzkd-5uqrA:
undetectable
5dzkr-5uqrA:
undetectable		 5dzkd-5uqrA:
undetectable
5dzkr-5uqrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_U_BEZU801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5uqr 2-METHYLCITRATE
SYNTHASE,
MITOCHONDRIAL
(Aspergillus
fumigatus) 		4 / 6 SER A 146
ALA A 208
HIS A 147
LEU A 231
 None
 1.22A 5dzkg-5uqrA:
undetectable
5dzku-5uqrA:
undetectable		 5dzkg-5uqrA:
undetectable
5dzku-5uqrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 5uqr 2-METHYLCITRATE
SYNTHASE,
MITOCHONDRIAL
(Aspergillus
fumigatus) 		4 / 8 SER A 292
ALA A 183
ASP A 202
SER A 180
 None
 0.80A 5l5fY-5uqrA:
undetectable
5l5fZ-5uqrA:
undetectable		 5l5fY-5uqrA:
16.67
5l5fZ-5uqrA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIX_A_OQRA302_0
(SULFOTRANSFERASE)		 5uqr 2-METHYLCITRATE
SYNTHASE,
MITOCHONDRIAL
(Aspergillus
fumigatus) 		5 / 9 LEU A 207
VAL A 440
LEU A 125
ASP A 445
SER A 203
 None
 1.50A 5tixA-5uqrA:
undetectable		 5tixA-5uqrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5uqr 2-METHYLCITRATE
SYNTHASE,
MITOCHONDRIAL
(Aspergillus
fumigatus) 		4 / 8 PRO A 359
VAL A 407
LEU A 265
ILE A  92
 None
 0.90A 5y1yA-5uqrA:
undetectable		 5y1yA-5uqrA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_C_9CRC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5uqr 2-METHYLCITRATE
SYNTHASE,
MITOCHONDRIAL
(Aspergillus
fumigatus) 		5 / 12 ILE A 171
ALA A 175
ALA A 174
LEU A 155
LEU A 298
 None
 1.04A 5z12C-5uqrA:
undetectable		 5z12C-5uqrA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5uqr 2-METHYLCITRATE
SYNTHASE,
MITOCHONDRIAL
(Aspergillus
fumigatus) 		5 / 12 ILE A 171
ALA A 175
ALA A 174
LEU A 155
LEU A 298
 None
 0.97A 6a5yD-5uqrA:
undetectable		 6a5yD-5uqrA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_B_REAB601_1
(RETINOIC ACID
RECEPTOR)		 5uqr 2-METHYLCITRATE
SYNTHASE,
MITOCHONDRIAL
(Aspergillus
fumigatus) 		5 / 10 ARG A 219
LEU A 216
LEU A 297
GLY A 431
VAL A 428
 None
 1.15A 6eu9B-5uqrA:
undetectable		 6eu9B-5uqrA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HXI_B_ACTB706_0
(SUCCINYL-COA LIGASE
(ADP-FORMING)
SUBUNIT ALPHA)		 5uqr 2-METHYLCITRATE
SYNTHASE,
MITOCHONDRIAL
(Aspergillus
fumigatus) 		4 / 5 HIS A 269
ARG A 360
PHE A 430
ARG A 434
 OAA  A 501 (-3.9A)
OAA  A 501 (-3.0A)
None
OAA  A 501 (-3.0A)
 0.67A 6hxiB-5uqrA:
16.0		 6hxiB-5uqrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HXI_D_ACTD703_0
(SUCCINYL-COA LIGASE
(ADP-FORMING)
SUBUNIT ALPHA)		 5uqr 2-METHYLCITRATE
SYNTHASE,
MITOCHONDRIAL
(Aspergillus
fumigatus) 		5 / 5 HIS A 269
ARG A 360
ASP A 408
PHE A 430
ARG A 434
 OAA  A 501 (-3.9A)
OAA  A 501 (-3.0A)
None
None
OAA  A 501 (-3.0A)
 0.64A 6hxiD-5uqrA:
17.2		 6hxiD-5uqrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_1
(ADENOSINE DEAMINASE)		 5uqr 2-METHYLCITRATE
SYNTHASE,
MITOCHONDRIAL
(Aspergillus
fumigatus) 		4 / 4 HIS A 280
LEU A 286
TYR A 195
GLY A 449
 None
 1.16A 6n91A-5uqrA:
undetectable		 6n91A-5uqrA:
18.39